Results 161 to 170 of about 13,819 (214)
Some of the next articles are maybe not open access.
Annual Review of Pharmacology and Toxicology, 2001
Lysophospholipids (LPs), including lysophosphatidic acid and sphingosine 1-phosphate, produce many cellular effects. However, the prolonged absence of any cloned and identified LP receptor has left open the question of how these lipids actually bring about these effects.
N, Fukushima +4 more
openaire +3 more sources
Lysophospholipids (LPs), including lysophosphatidic acid and sphingosine 1-phosphate, produce many cellular effects. However, the prolonged absence of any cloned and identified LP receptor has left open the question of how these lipids actually bring about these effects.
N, Fukushima +4 more
openaire +3 more sources
Chaperone-like Properties of Lysophospholipids
Biochemical and Biophysical Research Communications, 2001Lysophospholipids are metabolic intermediates in phospholipid turnover, detergent molecules with membrane-modulating effects, and multifunctional cellular growth factors in eukaryotic cells. In bacterial cells, lysophospholipids are mostly found in the form of lysophosphatidylethanolamine.
Gilbert Richarme +2 more
exaly +3 more sources
Lysophospholipids--Receptor Revelations
Science, 2001Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in ...
T, Hla +4 more
openaire +2 more sources
Lysophospholipids as biosurfactants
Colloids and Surfaces, 1987Abstract Lysophospholipids are surface-active amphiphiles generated naturally in biological membranes by the action of phospholipases. These surfactants contain only one long chain fatty acyl group and therefore have much higher critical micelle concentrations than the parent phospholipids.
Richard E. Stafford, Edward A. Dennis
openaire +1 more source
Lysophospholipids and the cardiovascular system
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) have varied effects on the cardiovascular system. S1P is necessary for normal vascular development and may play an important role in angiogenesis. These molecules may exert potentially detrimental effects.
openaire +2 more sources
Mechanisms of cardioprotection by lysophospholipids
Journal of Cellular Biochemistry, 2004AbstractThe lysophospholipids sphingosine 1‐phosphate (S1P) and lysophosphosphatidic acid (LPA) reduce mortality in hypoxic cardiac myocytes. S1P is also cardioprotective in both mouse and rat models of cardiac ischemia/reperfusion (I/R) injury. Although these results are consistent with prior work in other cell types, it is not known what signaling ...
openaire +2 more sources
Biological effects of lysophospholipids
2006Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are potent biologically active lipid mediators that exert a wide range of cellular effects through specific G protein-coupled receptors. To date, four LPA receptors and five S1P receptors have been identified.
R, Rivera, J, Chun
openaire +2 more sources
Lysophospholipids as Mediators of Immunity
2006Lysophospholipids (LPLs) are lipid-derived signaling molecules exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Originally identified as serum-associated growth factors, these mediators now are known to signal through a family of diverse G protein-coupled receptors (GPCRs). Virtually all cells that participate in the immune
Debby A, Lin, Joshua A, Boyce
openaire +2 more sources
Biological functions of bacterial lysophospholipids
2023Lysophospholipids (LPLs) are lipid-derived metabolic intermediates in the cell membrane. The biological functions of LPLs are distinct from their corresponding phospholipids. In eukaryotic cells LPLs are important bioactive signaling molecules that regulate many important biological processes, but in bacteria the function of LPLs is still not fully ...
Cao, Xuefeng +2 more
openaire +2 more sources
Lysophospholipids in the nervous system
Prostaglandins & Other Lipid Mediators, 2005This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) entitled "Targeted Lipidomics ...
openaire +2 more sources