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Druggable Lysophospholipid Signaling Pathways
2020Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with multiple physiological and pathological roles being described in almost every major organ system. In this review we discuss LPA signaling pathways as emerging drug targets for multiple conditions relevant to human health and disease.
Keisuke, Yanagida, William J, Valentine
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Lysophospholipid mediators of immunity and neoplasia
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002Lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and some other structurally related lysophospholipids are active growth factors and stimuli for diverse cellular functions. LPA and S1P promote early T cell migration to tissue sites of immune responses and regulate T cell proliferation and secretion of numerous cytokines.
Mei Chuan, Huang +4 more
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Lysophospholipid variants in hepatocellular carcinoma
Journal of Surgical Research, 2013The U.S. incidence of hepatocellular carcinoma (HCC) is increasing and is linked to hepatitis C (HepC) infection, alcohol toxicity, and obesity. This manuscript examines lysophosphatidic acid (LPA) variant biosynthesis as a biomarker and potential therapeutic target for HCC.Serum LPA variant levels were determined in patients with HepC ± HCC, alcoholic
Nicholas J, Skill +5 more
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Lysophospholipid Receptors in the Nervous System
Neurochemical Research, 2002The lysophospholipid mediators, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), are responsible for cell signaling in diverse pathways including survival, proliferation, motility, and differentiation. Most of this signaling occurs through an eight-member family of G-protein coupled receptors once known as the endothelial differentiation ...
Rachelle E, Toman, Sarah, Spiegel
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Lysophospholipid Receptors: Signaling and Biology
Annual Review of Biochemistry, 2004▪ Abstract Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis.
Isao, Ishii +3 more
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Complexities of lysophospholipid signalling in glioblastoma
Journal of Clinical Neuroscience, 2014Glioblastoma multiforme (GBM) is the most malignant brain tumour and continues to have a very poor median survival of 12-16 months despite current best therapies. These aggressive tumours always recur after treatment and are defined by their ability to diffusely infiltrate and invade normal brain parenchyma.
Wayne, Ng +5 more
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Interactions of lysophospholipids and mast cells
Nature, 1979PHOSPHOLIPID and protein are the major components of biological membranes, and much is known about their organisation in various cell membranes1,2. An important question concerns the existence and significance of specific protein–phospholipid interactions in membranes.
T W, Martin, D, Lagunoff
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Chemical approaches to the lysophospholipid receptors
Prostaglandins & Other Lipid Mediators, 2005Both ligand-based and GPCR privileged scaffold chemical tools have recently emerged to provide new insights into the function and physiology of the GPCR lysophospholipid receptors both in vitro and in vivo. Both rational, design-based approaches as well as hybrid approaches where high throughput screening has been coupled to an understanding of ...
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