Results 221 to 230 of about 19,633 (273)

Lysophospholipid Receptors

Annual Review of Pharmacology and Toxicology, 2001
Lysophospholipids (LPs), including lysophosphatidic acid and sphingosine 1-phosphate, produce many cellular effects. However, the prolonged absence of any cloned and identified LP receptor has left open the question of how these lipids actually bring about these effects.
N, Fukushima, I, Ishii, J J, Contos, J A, Weiner, J, Chun   +4 more
openaire   +3 more sources

Chaperone-like Properties of Lysophospholipids

Biochemical and Biophysical Research Communications, 2001
Lysophospholipids are metabolic intermediates in phospholipid turnover, detergent molecules with membrane-modulating effects, and multifunctional cellular growth factors in eukaryotic cells. In bacterial cells, lysophospholipids are mostly found in the form of lysophosphatidylethanolamine.
Gilbert Richarme
exaly   +3 more sources

Lysophospholipids--Receptor Revelations

Science, 2001
Upon cell activation, membrane phospholipids are metabolized into potent lysophospholipid (LP) mediators, such as sphingosine 1-phosphate and lysophosphatidic acid. LPs fulfill signaling roles in organisms as diverse as yeast and humans. The recent discovery of G protein–coupled receptors for LPs in higher eukaryotes, and their involvement in ...
T, Hla, M J, Lee, N, Ancellin, J H, Paik, M J, Kluk   +4 more
openaire   +2 more sources

Lysophospholipids as biosurfactants

Colloids and Surfaces, 1987
Abstract Lysophospholipids are surface-active amphiphiles generated naturally in biological membranes by the action of phospholipases. These surfactants contain only one long chain fatty acyl group and therefore have much higher critical micelle concentrations than the parent phospholipids.
Richard E. Stafford, Edward A. Dennis
openaire   +1 more source

Mechanisms of cardioprotection by lysophospholipids

Journal of Cellular Biochemistry, 2004
AbstractThe lysophospholipids sphingosine 1‐phosphate (S1P) and lysophosphosphatidic acid (LPA) reduce mortality in hypoxic cardiac myocytes. S1P is also cardioprotective in both mouse and rat models of cardiac ischemia/reperfusion (I/R) injury. Although these results are consistent with prior work in other cell types, it is not known what signaling ...
openaire   +2 more sources

Lysophospholipids in Lung Inflammatory Diseases

2021
The lysophospholipids (LPLs) belong to a group of bioactive lipids that play pivotal roles in several physiological and pathological processes. LPLs are derivatives of phospholipids and consist of a single hydrophobic fatty acid chain, a hydrophilic head, and a phosphate group with or without a large molecule attached.
Jing, Zhao, Yutong, Zhao
openaire   +2 more sources

Lysophospholipids and the cardiovascular system

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
The lysophospholipids sphingosine-1-phosphate (S1P) and lysophosphatidic acid (LPA) have varied effects on the cardiovascular system. S1P is necessary for normal vascular development and may play an important role in angiogenesis. These molecules may exert potentially detrimental effects.
openaire   +2 more sources

Biological effects of lysophospholipids

2006
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are potent biologically active lipid mediators that exert a wide range of cellular effects through specific G protein-coupled receptors. To date, four LPA receptors and five S1P receptors have been identified.
R, Rivera, J, Chun
openaire   +2 more sources

Druggable Lysophospholipid Signaling Pathways

2020
Lysophosphatidic acid (LPA) has major roles as a bioactive signaling molecule, with multiple physiological and pathological roles being described in almost every major organ system. In this review we discuss LPA signaling pathways as emerging drug targets for multiple conditions relevant to human health and disease.
Keisuke, Yanagida, William J, Valentine
openaire   +2 more sources