Results 231 to 240 of about 19,633 (273)

Lysophospholipids as Mediators of Immunity

2006
Lysophospholipids (LPLs) are lipid-derived signaling molecules exemplified by lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Originally identified as serum-associated growth factors, these mediators now are known to signal through a family of diverse G protein-coupled receptors (GPCRs). Virtually all cells that participate in the immune
Debby A, Lin, Joshua A, Boyce
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Lysophospholipid mediators of immunity and neoplasia

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Lysophosphatidic acid (LPA), sphingosine 1-phosphate (S1P) and some other structurally related lysophospholipids are active growth factors and stimuli for diverse cellular functions. LPA and S1P promote early T cell migration to tissue sites of immune responses and regulate T cell proliferation and secretion of numerous cytokines.
Mei Chuan, Huang, Markus, Graeler, Geetha, Shankar, Juliet, Spencer, Edward J, Goetzl   +4 more
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Lysophospholipids in the nervous system

Prostaglandins & Other Lipid Mediators, 2005
This piece offers perspectives on the emerging roles of lysophospholipids, which include lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), for the biology and pathophysiology of the nervous system. It reflects opinions generated during a meeting sponsored by the National Institute on Drug Abuse (NIDA) entitled "Targeted Lipidomics ...
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Lysophospholipid variants in hepatocellular carcinoma

Journal of Surgical Research, 2013
The U.S. incidence of hepatocellular carcinoma (HCC) is increasing and is linked to hepatitis C (HepC) infection, alcohol toxicity, and obesity. This manuscript examines lysophosphatidic acid (LPA) variant biosynthesis as a biomarker and potential therapeutic target for HCC.Serum LPA variant levels were determined in patients with HepC ± HCC, alcoholic
Nicholas J, Skill, Wu, Jianmin, Xu, Yan, Zhenweng, Zhao, Alfred J, Tector, Mary A, Maluccio   +5 more
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Lysophospholipid Receptors in the Nervous System

Neurochemical Research, 2002
The lysophospholipid mediators, lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P), are responsible for cell signaling in diverse pathways including survival, proliferation, motility, and differentiation. Most of this signaling occurs through an eight-member family of G-protein coupled receptors once known as the endothelial differentiation ...
Rachelle E, Toman, Sarah, Spiegel
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Biological functions of bacterial lysophospholipids

2023
Lysophospholipids (LPLs) are lipid-derived metabolic intermediates in the cell membrane. The biological functions of LPLs are distinct from their corresponding phospholipids. In eukaryotic cells LPLs are important bioactive signaling molecules that regulate many important biological processes, but in bacteria the function of LPLs is still not fully ...
Cao, Xuefeng, van Putten, Jos P.M., Wösten, Marc M.S.M.   +2 more
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Lysophospholipids are natriuretic and diuretic in rats

American Journal of Physiology-Renal Physiology, 1988
The effects of lysophosphatidylcholine (LPC) and some of its analogues on renal sodium (UNaV) and water excretion (V) were examined in the pentobarbital sodium-anesthetized rat. LPC caused the increase in UNaV and V with a steep dose response. The natriuretic effect began within 20 min after a bolus injection and lasted for 7 h.
A L, Rauch, V M, Buckalew
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Complexities of lysophospholipid signalling in glioblastoma

Journal of Clinical Neuroscience, 2014
Glioblastoma multiforme (GBM) is the most malignant brain tumour and continues to have a very poor median survival of 12-16 months despite current best therapies. These aggressive tumours always recur after treatment and are defined by their ability to diffusely infiltrate and invade normal brain parenchyma.
Wayne, Ng, Alice, Pébay, Katharine, Drummond, Antony, Burgess, Andrew H, Kaye, Andrew, Morokoff   +5 more
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Lysophospholipid Receptors: Signaling and Biology

Annual Review of Biochemistry, 2004
▪ Abstract  Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis.
Isao, Ishii, Nobuyuki, Fukushima, Xiaoqin, Ye, Jerold, Chun   +3 more
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Lysophospholipid receptors in cell signaling

Biochemistry (Moscow), 2007
There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors.
T I, Torkhovskaya, O M, Ipatova, T S, Zakharova, M M, Kochetova, E M, Khalilov   +4 more
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