Results 31 to 40 of about 18,174 (203)

Metabolomics of aging assessed in individual parasitoid wasps [PDF]

, 2016
Metabolomics studies of low-biomass organisms, such as small insects, have previously relied on the pooling of biological samples to overcome detection limits, particularly using NMR.
A Houston, A Lizé, A Malmendal, A Wong, B Visser, BJ Huho, C Phalaraksh, CD Nichols, CJP Snart, D Iwahata, DA Roach, EG Bligh, EG Nagato, EJ Hayes, EL Arrese, EM Lenz, EP Caragata, G van Meer, GE Heimpel, H Colinet, H Colinet, H Pates, H Wu, J Casas, J Casas, J Overgaard, JC Hoxmeier, K Dettmer, KS Pedersen, L Coquin, LE Hugo, MA Jervis, MH Wang, MJ Laye, MR Michaud, N Moriwaki, NA Irvin, NM Teets, P Sarup, PE Cook, R Rivera, R Wu, RJ Mishur, SK Khidr, T Kind, V Foray, V Koštál, W Mamai, WB Dunn, WCEP Verberk, Y Wang   +50 more
core   +2 more sources

Quantification and Localisation of New Brain Lipid Synthesis Using Deuterium Oxide and High Resolution Mass Spectrometry

Angewandte Chemie, EarlyView.
Liquid chromatography tandem mass spectrometry and mass spectrometry imaging were used in combination with deuterium oxide administration to quantify and localise newly synthesised myelin lipids in the mouse brain. This methodology, used here to show sites of myelin repair, enables the measurement of dynamic lipid synthesis in living systems and ...
Catherine Zhang, Jesse A. Michael, Jonathan D. Teo, Huitong Song, Mika T. Westerhausen, Shadrack M. Mutuku, Shane R. Ellis, Anthony S. Don   +7 more
wiley   +2 more sources

Preventing the Increase in Lysophosphatidic Acids: A New Therapeutic Target in Pulmonary Hypertension?

Metabolites, 2021
Cardiovascular diseases (CVD) are the leading cause of premature death and disability in humans that are closely related to lipid metabolism and signaling.
Thomas Duflot, Ly Tu, Matthieu Leuillier, Hind Messaoudi, Déborah Groussard, Guillaume Feugray, Saïda Azhar, Raphaël Thuillet, Fabrice Bauer, Marc Humbert, Vincent Richard, Christophe Guignabert, Jérémy Bellien   +12 more
doaj   +1 more source

Metabolic reprogramming ensures cancer cell survival despite oncogenic signaling blockade [PDF]

, 2017
There is limited knowledge about the metabolic reprogramming induced by cancer therapies, and how this contributes to therapeutic resistance. Here we show that although inhibition of PI3K-AKT-mTOR signaling markedly decreased glycolysis and restrained
Amling, C, Cheng, L, Drake, J, Evans, M, Garg, D, Kolahi, K, Liu, J-J, Lue, H-W, Martinez-Acevedo, A, Nomura, D, O'Donnell, Valerie, Podolak, J, Rantala, J, Rao, S, Ritz, A, Thomas, G, Thornburg, K, Truillet, C, Tyner, J, Xue, C-H   +19 more
core   +2 more sources

Acute Hypercapnia/Ischemia Alters the Esterification of Arachidonic Acid and Docosahexaenoic Acid Epoxide Metabolites in Rat Brain Neutral Lipids. [PDF]

, 2020
In the brain, approximately 90% of oxylipins are esterified to lipids. However, the significance of this esterification process is not known. In the present study, we (1) validated an aminopropyl solid phase extraction (SPE) method for separating ...
Bazinet, Richard P, Hammock, Bruce D, Metherel, Adam H, Newman, John W, Otoki, Yurika, Pedersen, Theresa, Taha, Ameer Y, Yang, Jun   +7 more
core   +1 more source

Characterization of phospholipase B of Culex pipiens fatigans

Journal of Lipid Research, 1969
Phospholipase B has been found in the mosquito Culex pipiens fatigans, and some of its properties have been studied. The enzyme had a high optimum temperature (45°C) and broad alkaline pH optimum (8-9).
R. Hanumantha Rao, D. Subrahmanyam
doaj   +1 more source

Lysophosphatidic Acid Receptor 5 (LPA₅) Knockout Ameliorates the Neuroinflammatory Response In Vivo and Modifies the Inflammatory and Metabolic Landscape of Primary Microglia In Vitro

Cells, 2022
Systemic inflammation induces alterations in the finely tuned micromilieu of the brain that is continuously monitored by microglia. In the CNS, these changes include increased synthesis of the bioactive lipid lysophosphatidic acid (LPA), a ligand for the
Lisha Joshi, Ioanna Plastira, Eva Bernhart, Helga Reicher, Zhanat Koshenov, Wolfgang F. Graier, Nemanja Vujic, Dagmar Kratky, Richard Rivera, Jerold Chun, Wolfgang Sattler   +10 more
doaj   +1 more source

Proliferative glioblastoma cancer cells exhibit persisting temporal control of metabolism and display differential temporal drug susceptibility in chemotherapy [PDF]

, 2019
Even in immortalized cell lines, circadian clocks regulate physiological processes in a time-dependent manner, driving transcriptional and metabolic rhythms, the latter being able to persist without transcription.
Gaveglio, Virginia Lucía, Gorne, Lucas Damián, Guido, Mario Eduardo, Pasquaré, Susana Juana, Salvador, Gabriela Alejandra, Sosa Alderete, Lucas Gastón, Wagner, Paula Micaela   +6 more
core   +1 more source

Understanding the Mechanism of Translocation of Adenylate Cyclase Toxin across Biological Membranes [PDF]

, 2017
Adenylate cyclase toxin (ACT) is one of the principal virulence factors secreted by the whooping cough causative bacterium Bordetella pertussis, and it has a critical role in colonization of the respiratory tract and establishment of the disease.
Belloso Uribe, Kepa, Etxaniz Iriondo, Asier, González Bullón, David, Martín Plágaro, César Augusto, Ostolaza Echabe, Elena Amaya   +4 more
core   +3 more sources

Lysophospholipid receptors: Signalling, pharmacology and regulation by lysophospholipid metabolism

Biochimica et Biophysica Acta (BBA) - Biomembranes, 2007
The lysophospholipids, sphingosine-1-phosphate (S1P), lysophosphatidic acid (LPA), sphingosylphosphorylcholine (SPC) and lysophosphatidylcholine (LPC), activate diverse groups of G-protein-coupled receptors that are widely expressed and regulate decisive cellular functions.
Meyer zu Heringdorf, Dagmar, Jakobs, Karl H.   +1 more
openaire   +2 more sources