Results 171 to 180 of about 929 (218)
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The transport of lysosomal enzymes
Journal of Supramolecular Structure, 1977AbstractThis paper reviews the experimental evidence for the proposal that hydrolytic enzymes are introduced into lysosomes of cultured fibroblasts only after secretion and receptormediated recapture.
E F, Neufeld +3 more
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Lysosomal sequestration of cytosolic enzymes and lysosomal thiol cathepsins
Advances in Enzyme Regulation, 1985Cytoplasmic proteins are degraded with different half-lives in vivo. Large parts of proteins are believed to be degraded primarily in autophagic vacuoles-lysosomal system. However, the mechanism by which cell proteins are delivered to lysosomes and whether such a process might be selective for certain cell proteins are still unresolved. We examined the
N, Katunuma, E, Kominami
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[Lysosome enzyme pseudodeficiency].
Revue neurologique, 2001Inherited deficiency of lysosomal hydrolase often displays different clinical features. However, a greatly reduced enzyme activity may be observed in healthy individuals. This pseudo-deficiency concerns at least nine lysosomal hydrolases. When a deficiency has been proved, the presence of mutations known to cause pseudodeficiencies must be searched ...
P, Bronner +5 more
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Enzyme Replacement for Lysosomal Diseases
Annual Review of Medicine, 2006Following the demonstration of the nature of the enzymatic defects in the sphingolipid storage disorders in the mid-1960s, consideration was directed to the development of therapy for patients with these conditions. High on the list of possibilities was enzyme supplementation or replacement.
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Biosynthesis of lysosomal enzymes
Trends in Biochemical Sciences, 1980During their synthesis lysosomal enzymes are subjected to extensive processing, which involves both the protein and the sugar moieties of these molecules. The many modifications to the sugars appear to play a decisive role in sorting those molecules to be delivered into the lysosomes from those to be secreted.
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Transport of Lysosomal Enzymes
2005More than 50 acid hydrolases involved in the ordered lysosomal degradation of a variety of proteins, lipids, carbohydrates, and nucleic acids have been identified. The hydrolases are enclosed by a membrane containing a set of highly glycosylated lysosomal membrane proteins.
Stephan Storch, Thomas Braulke
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Carbohydrate-active enzymes (CAZymes) in the gut microbiome
Nature Reviews Microbiology, 2022Jacob F Wardman +2 more
exaly
Structural biology of CRISPR–Cas immunity and genome editing enzymes
Nature Reviews Microbiology, 2022Joy Y Wang +2 more
exaly
Lysosomal enzymes in invertebrate leucocytes
Journal of Cellular and Comparative Physiology, 1964A, JANOFF, E, HAWRYLKO
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