Results 21 to 30 of about 686,065 (200)
Molecular Genetics and Metabolism Reports, 2023 Mucolipidosis type II and III (MLII/III) is caused by defects in the mannose-6-phosphate system, which is essential to target most of the lysosomal hydrolases to the lysosome.
Xinying Hong +4 more
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Heliyon, 2022 Lysosomal biogenesis is an essential adaptive process by which lysosomes exert their function in maintaining cellular homeostasis. Defects in lysosomal enzymes and functions lead to lysosome-related diseases, including lysosomal storage diseases and ...
Xiao Ding +11 more
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IMPROVING THE THERAPEUTIC POTENTIAL OF LYSOSOMAL ENZYMES TO TREAT CNS IN LYSOSOMAL STORAGE DISORDERS [PDF]
, 2020 Lysosomal storage disorders (LSD) are a large group of inherited genetic diseases caused by impaired activity of lysosomal enzymes leading to accumulation of undigested macromolecules within the lysosomes and thus cell dysfunction.
AIELLO, ROSANNA GILDA
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Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes [PDF]
Journal of HerbMed Pharmacology, 2021 Introduction: Siphonochilus aethiopicus is a medicinal plant widely used in the treatment of many inflammatory conditions such as arthritis. The objective of this study was therefore to evaluate the antioxidant and anti-inflammatory properties of ...
Elize Dadaya +4 more
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Mistargeting of the lectin ERGIC-53 to the endoplasmic reticulum of HeLa cells impairs the secretion of a lysosomal enzyme [PDF]
, 1998 ERGIC-53, a homo-oligomeric recycling protein associated with the ER-Golgi intermediate compartment (ERGIC), has properties of a mannose-selective lectin in vitro, suggesting that it may function as a transport receptor for glycoproteins in the early ...
Florence Vollenweider +11 more
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Subverting lysosomal function in Trypanosoma brucei. [PDF]
, 2015 In this issue of Microbial Cell, Koh and colleagues present data highlighting the utility of the lysosomotropic compound L-leucyl-L-leucyl methyl ester (LeuLeu-OMe) as an anti-Trypanosoma brucei agent, adding to the range of compounds that either ...
Sam Alsford, Alsford, Sam
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Molecules, 2021 The aim of the study is to evaluate oxidant–antioxidant balance as well as lysosomal and anti-protease activities in ovarian cancer since it has been emphasized that the crucial inducing factor of carcinogenesis may be reactive oxygen/nitrogen species or,
Paweł Sutkowy +6 more
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Inflammation-Involved Proteins in Blood Serum of Cataract Patients—A Preliminary Study
Biomedicines, 2023 Approximately 50% of all global blindness is caused by cataract in adults aged ≥50 years. The mechanisms of the disease are most arguably related to a redox imbalance and inflammation; therefore, the aim of the study was to evaluate the processes ...
Paweł Sutkowy +3 more
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Diagnostic Pathology, 2010 Background Lysosomal storage diseases (LSD) are inherited disorders caused by deficiency of lysosomal enzymes in which early diagnosis is essential to provide timely treatment. This study reports interval values for the activity of lysosomal enzymes that
Martins Ana M +4 more
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Distribution of chromaffin secretory vesicles, acetylcholinesterase, and lysosomal enzymes in sucrose and percoll gradients [PDF]
, 1984 Crude chromaffin secretory vesicles, obtained by differential centrifugation, were further purified on isotonic (Percoll) gradients. The chromaffin vesicle fractions recovered from the gradients contain acetylcholinesterase as well as lysosomal enzymes ...
Gratzl, Manfred
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