Results 21 to 30 of about 87,336 (259)

Development of Organelle Replacement Therapy Using a Stearyl-Polyhistidine Peptide against Lysosomal Storage Disease Cells

open access: yesMolecules, 2019
We previously reported on a polyhistidine peptide, His16 peptide, as a new cell-penetrating peptide. This peptide is anticipated to be a new carrier for drug delivery systems (DDSs) for targeting intracellular lysosomes because it can transport ...
Taiki Hayashi   +3 more
doaj   +1 more source

Newborn Screening for Krabbe Disease—Illinois Experience: Role of Psychosine in Diagnosis of the Disease

open access: yesInternational Journal of Neonatal Screening, 2021
Population-based newborn screening for Krabbe disease was initiated by measurement of galactocerebrosidase (GALC) activity in the state of Illinois in December 2017.
Khaja Basheeruddin   +4 more
doaj   +1 more source

Lysosomal Enzymes in Bruised Tissue.

open access: yesExperimental Biology and Medicine, 1965
SummaryLysosomal DNase, RNase, β-glucuronidase and β-galactosidase activities in experimentally inflicted poultry breast bruises increased by the second day post contusion, reached a maximum between the third and fifth day and then declined toward normal as the bruises showed gross morphological healing.
W E, BROWN, M K, HAMDY
openaire   +2 more sources

The activity of lysosomal hydrolases (proteases and nucleases) in salmon (Salmo salar L.) juveniles of different age categories from the Indera River

open access: yesTransactions of the Karelian Research Centre of the Russian Academy of Sciences, 2016
The results on the activity of lysosomal hydrolases (proteases (cathepsins) and nucleases) in salmon (Salmo salar L.) underyearlings (0+), 1+ and 2+ parr, and smolts (2+, 3+)from the Indera River (White Sea drainage basin) are reported, testifying their ...
Marina Krupnova   +5 more
doaj   +1 more source

Antioxidant and anti-inflammatory properties of the methanolic extract of Siphonochilus aethiopicus rhizomes [PDF]

open access: yesJournal of HerbMed Pharmacology, 2021
Introduction: Siphonochilus aethiopicus is a medicinal plant widely used in the treatment of many inflammatory conditions such as arthritis. The objective of this study was therefore to evaluate the antioxidant and anti-inflammatory properties of ...
Elize Dadaya   +4 more
doaj   +1 more source

Conformational dynamics of free and membrane-bound human Hsp70 in model cytosolic and endo-lysosomal environments

open access: yesCommunications Biology, 2021
Calvaresi et al. use hydrogen-deuterium exchange coupled to mass spectrometry to compare the conformational dynamics of the human heat shock protein Hsp70 when free and when associated with liposomes composed of common lysosomal lipids.
Valeria Calvaresi   +5 more
doaj   +1 more source

STUDIES ON THE RELEASE OF LYSOSOMAL ENZYMES FROM KIDNEY LYSOSOMES [PDF]

open access: yesThe Journal of Cell Biology, 1965
Incubation of kidney lysosomes at 37° results in a graded release of lysosomal enzymes. The release of enzyme occurs in two stages. First the enzymes become available to the substrate but remain sedimentable. Later the amount of soluble enzyme increases and eventually is almost equal to that of the available enzyme.
S, Shibko, J, Pangborn, A L, Tappel
openaire   +2 more sources

Lymphocyte Lysosomes and Lysosomal Enzymes in Chronic Lymphocytic Leukemia [PDF]

open access: yesBlood, 1973
Abstract Electron microscopic cytochemical and biochemical studies of lysosomal markers have been performed in unstimulated normal and chronic lymphotic leukemia (CLL) lymphocytes. Decreased activities of the lysosomal enzymes acid phosphatase and β-glucuronidase but not of the nonlysosomal enzyme malate dehydrogenase were observed in ...
S D, Douglas   +3 more
openaire   +2 more sources

The Abnormalities of Lysosomal Enzymes in Mucopolysaccharidoses [PDF]

open access: yesEuropean Journal of Biochemistry, 1968
The activity of acid hydrolases on 13 substrates has been measured in the liver of normal human subjects and of 32 patients with various forms of mucopolysaccharidoses. The most important abnormalities may be summarized as follows: In 3 patients, there was a complete absence of α‐fucosidase and an excess of fucose in the mucopolysaccharide fraction ...
F, Van Hoof, H G, Hers
openaire   +2 more sources

Golgi defect as a major contributor to lysosomal dysfunction

open access: yesFrontiers in Cell and Developmental Biology
The Golgi apparatus plays a crucial role in lysosome biogenesis and the delivery of lysosomal enzymes, essential for maintaining cellular homeostasis and ensuring cell survival. Deficiencies in Golgi structure and function can profoundly impact lysosomal
Sarah R. Akaaboune, Yanzhuang Wang
doaj   +1 more source

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