Results 31 to 40 of about 87,336 (259)
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Dose-Response, 2014 Present communication reports the effects of environmentally available, low doses of tetra chloro di benzo-p-dioxin (2,3,7,8 TCDD) to lysosomal enzymes in mice liver.
Jyoti Jigyasi, Rahul Kundu
doaj +1 more source
Biology Open, 2015 The lysosomal enzyme receptor protein (LERP) of Drosophila melanogaster is the ortholog of the mammalian cation-independent mannose 6-phosphate (Man 6-P) receptor, which mediates trafficking of newly synthesized lysosomal acid hydrolases to lysosomes ...
Medina Hasanagic +5 more
doaj +1 more source
Lysosomal hydrolases, from waste-bags effectors to essential multipurpose enzymes in liver fibrosis
Exploration of Digestive Diseases, 2023 Lysosomal hydrolases were once considered effectors of the waste disposal system of the cell, the endo-lysosomal system. However, they are now recognized as highly selective enzymes, which can modulate the function of several substrates, contributing to ...
Paloma Ruiz-Blázquez +2 more
doaj +1 more source
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
Renal Tubular Dysfunction with Valproate and CBZ
Pediatric Neurology Briefs, 1999 Renal tubular function in epileptic children receiving antiepileptic drugs was evaluated by measurement of lysosomal enzymes at Istanbul University, Turkey.
J Gordon Millichap
doaj +1 more source
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
Acid Angiotensinase as a Lysosomal Enzyme
Japanese Circulation Journal, 1969 1. Both acid angiotensinase and calcium-dependent neutral angiotensinase are widely distributed among various tissues of the rat. High activity of acid angiotensinase in such lysosome-rich tissues as kidney, spleen and liver suggests localization of this enzyme in lysosomes. 2. Main angiotensinases in rat liver are concentrated in lysosomal and soluble
MATSUNAGA, MASATO +4 more
openaire +3 more sources
FEBS Letters, EarlyView.Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley +1 more source
Data in Brief, 2016 In this data article we provide a detailed standard operating procedure for performing a tandem mass spectrometry, multiplex assay of 6 lysosomal enzymes for newborn screening of the lysosomal storage diseases Mucopolysaccharidosis-I, Pompe, Fabry ...
Susan Elliott +11 more
doaj +1 more source