Results 1 to 10 of about 299,168 (388)

Peripheral lysosome levels dictate mTORC1 inactivation even when catabolically impaired. [PDF]

Cell Commun Signal
Dang HQ, Forssén T, Pantelios S, Nteli Chatzioglou A, Kurzejamska E, Vincent CT, Ibrahim Y, Mutvei AP.   +7 more
europepmc   +2 more sources

Lysosome biogenesis: Regulation and functions

Journal of Cell Biology, 2021
Yang and Wang review the mechanisms regulating lysosome biogenesis and functions during the cellular response to diverse environmental cues and in organismal development and aging.
Chonglin Yang, Xiaochen Wang
semanticscholar   +1 more source

The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system

Nature Communications, 2022
Targeted protein degradation allows targeting undruggable proteins for therapeutic applications as well as eliminating proteins of interest for research purposes.
C. H. Ji, Hee Yeon Kim, Min Ju Lee, Ah Jung Heo, D. Park, Sungsu Lim, Seulgi Shin, Woo Seung Yang, Chang An Jung, Kunhong Kim, Eun Hye Jeong, Sun Ho Park, Su Bin Kim, Su Jin Lee, Jeong Eun Na, J. Kang, H. Chi, Hyun Tae Kim, Y. Kim, Bo Yeon Kim, Y. Kwon   +20 more
semanticscholar   +1 more source

Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.

PLoS ONE, 2021
Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates.
Golam T Saffi, Evan Tang, Sami Mamand, Subothan Inpanathan, Aaron Fountain, Leonardo Salmena, Roberto J Botelho   +6 more
doaj   +1 more source

Reducing posttraumatic stress in parents of patients with a rare inherited metabolic disorder using eye movement desensitization and reprocessing therapy: a case study

Orphanet Journal of Rare Diseases, 2021
Parents of children with severe inborn errors of metabolism frequently face stressful events related to the disease of their child and are consequently at high risk for developing parental posttraumatic stress disorder (PTSD).
Thirsa Conijn, Lotte Haverman, Frits A. Wijburg, Carlijn De Roos   +3 more
doaj   +1 more source

Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion

Nature Communications, 2023
Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeostasis ...
Tianshu Hao, Jianglong Yu, Zhida Wu, Jie Jiang, Longlong Gong, BingJun Wang, Hanze Guo, Huabin Zhao, Bin Lu, S. Engelender, He He, Zhiyin Song   +11 more
semanticscholar   +1 more source

Secretory autophagy maintains proteostasis upon lysosome inhibition

Journal of Cell Biology, 2022
Solvik et al. reveal that the autophagy machinery facilitates the secretion of autophagy cargo receptors and other cellular components via extracellular vesicles and particles in response to lysosome inhibition or impaired autophagosome maturation.
T. Solvik, Tan A Nguyen, Yu-Hsiu Tony Lin, Timothy Marsh, E. Huang, Arun P. Wiita, Jayanta Debnath, Andrew M. Leidal   +7 more
semanticscholar   +1 more source

Lysosome transport as a function of lysosome diameter. [PDF]

PLoS ONE, 2014
Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along ...
Debjyoti Bandyopadhyay, Austin Cyphersmith, Jairo A Zapata, Y Joseph Kim, Christine K Payne   +4 more
doaj   +1 more source

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair

EMBO Journal, 2022
Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are repaired by the ESCRT machinery. Here, we describe an additional mechanism for lysosome repair that is activated independently of ESCRT recruitment.
Maja Radulovic, E. M. Wenzel, Sania Gilani, L. K. Holland, A. H. Lystad, Santosh Phuyal, V. Olkkonen, A. Brech, M. Jäättelä, Kenji Maeda, C. Raiborg, H. Stenmark   +11 more
semanticscholar   +1 more source

Lysosome dysfunction as a cause of neurodegenerative diseases: Lessons from frontotemporal dementia and amyotrophic lateral sclerosis.

Neurobiology of Disease, 2021
Frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS) are fatal neurodegenerative disorders that are thought to exist on a clinical and pathological spectrum. FTD and ALS are linked by shared genetic causes (i.e.
Jessica Root, Paola Merino, A. Nuckols, Michelle A. Johnson, Thomas L Kukar   +4 more
semanticscholar   +1 more source