Results 1 to 10 of about 249,586 (383)

Lysosomes and lysosome‐related organelles in immune responses [PDF]

FEBS Open Bio, 2022
The catabolic, degradative capacity of the endo‐lysosome system is put to good use in mammalian immune responses as is their recently established status as signaling platforms.
C. Watts
semanticscholar   +5 more sources

Hypoxia-reprogramed megamitochondrion contacts and engulfs lysosome to mediate mitochondrial self-digestion

Nature Communications, 2023
Mitochondria are the key organelles for sensing oxygen, which is consumed by oxidative phosphorylation to generate ATP. Lysosomes contain hydrolytic enzymes that degrade misfolded proteins and damaged organelles to maintain cellular homeostasis ...
Tianshu Hao, Jianglong Yu, Zhida Wu, Jie Jiang, Longlong Gong, Bingjun Wang, Hanze Guo, Huabin Zhao, Bin Lu, S. Engelender, He He, Zhiyin Song   +11 more
semanticscholar   +1 more source

Lysosome biogenesis: Regulation and functions

Journal of Cell Biology, 2021
Yang and Wang review the mechanisms regulating lysosome biogenesis and functions during the cellular response to diverse environmental cues and in organismal development and aging.
Chonglin Yang, Xiaochen Wang
semanticscholar   +1 more source

The AUTOTAC chemical biology platform for targeted protein degradation via the autophagy-lysosome system

Nature Communications, 2022
Targeted protein degradation allows targeting undruggable proteins for therapeutic applications as well as eliminating proteins of interest for research purposes.
C. H. Ji, H. Kim, Min Ju Lee, Ah Jung Heo, D. Park, Sungsu Lim, Seulgi Shin, Woo Seung Yang, Chang An Jung, Kunhong Kim, Eun Hye Jeong, Sun Ho Park, Su Bin Kim, Su Jin Lee, Jeong Eun Na, J. Kang, H. Chi, Hyun Tae Kim, Y. Kim, Bo Yeon Kim, Y. Kwon   +20 more
semanticscholar   +1 more source

Secretory autophagy maintains proteostasis upon lysosome inhibition

Journal of Cell Biology, 2022
Solvik et al. reveal that the autophagy machinery facilitates the secretion of autophagy cargo receptors and other cellular components via extracellular vesicles and particles in response to lysosome inhibition or impaired autophagosome maturation.
T. Solvik, Tan A Nguyen, Yu-Hsiu Tony Lin, Timothy Marsh, E. Huang, Arun P. Wiita, Jayanta Debnath, Andrew M. Leidal   +7 more
semanticscholar   +1 more source

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair

EMBO Journal, 2022
Lysosome integrity is essential for cell viability, and lesions in lysosome membranes are repaired by the ESCRT machinery. Here, we describe an additional mechanism for lysosome repair that is activated independently of ESCRT recruitment.
Maja Radulovic, E. M. Wenzel, Sania Gilani, Lya Kk Holland, A. H. Lystad, Santosh Phuyal, V. Olkkonen, A. Brech, M. Jäättelä, Kenji Maeda, C. Raiborg, H. Stenmark   +11 more
semanticscholar   +1 more source

Current methods to analyze lysosome morphology, positioning, motility and function

Traffic : the International Journal of Intracellular Transport, 2022
Since the discovery of lysosomes more than 70 years ago, much has been learned about the functions of these organelles. Lysosomes were regarded as exclusively degradative organelles, but more recent research has shown that they play essential roles in ...
Duarte C. Barral, Leopoldo Staiano, Cláudia Guimas Almeida, D. Cutler, Emily R. Eden, C. Futter, A. Galione, A. R. Marques, D. Medina, G. Napolitano, C. Settembre, Otília V. Vieira, J. Aerts, Peace Atakpa-Adaji, Gemma Bruno, A. Capuozzo, E. De Leonibus, Chiara Di Malta, Cristina Escrevente, A. Esposito, P. Grumati, M. Hall, Rita O. Teodoro, S. Lopes, J. Luzio, J. Monfregola, S. Montefusco, F. Platt, R. Polishchuck, M. De Risi, Irene Sambri, C. Soldati, M. Seabra   +32 more
semanticscholar   +1 more source

Lysosome biology in autophagy

Cell Discovery, 2020
Autophagy is a major intracellular degradation system that derives its degradative abilities from the lysosome. The most well-studied form of autophagy is macroautophagy, which delivers cytoplasmic material to lysosomes via the double-membraned ...
Willa Yim, N. Mizushima
semanticscholar   +1 more source

Autophagic lysosome reformation in health and disease

Autophagy, 2022
Lysosomes are the primary degradative compartment within cells and there have been significant advances over the past decade toward understanding how lysosome homeostasis is maintained.
Randini Nanayakkara, R. Gurung, S. Rodgers, M. Eramo, G. Ramm, C. Mitchell, M. McGrath   +6 more
semanticscholar   +1 more source

Dysregulation of mitochondria-lysosome contacts by GBA1 dysfunction in dopaminergic neuronal models of Parkinson’s disease

Nature Communications, 2021
Mitochondria-lysosome contacts are recently identified sites for mediating crosstalk between both organelles, but their role in normal and diseased human neurons remains unknown.
Soojin Kim, Y. Wong, Fanding Gao, D. Krainc   +3 more
semanticscholar   +1 more source