Molecularly Built Ligands Degrade Membrane Receptors via Enhancing Their Accumulation in Lysosomes. [PDF]
ACS Cent SciZhang D +5 more
europepmc +2 more sources
Spatio-temporal processes in autophagosome-lysosome fusion [PDF]
Medical ReviewMacroautophagy/autophagy is a lysosome-dependent degradation process involved in cellular energy metabolism, recycling and quality control. Autophagy is a highly dynamic and precisely regulated process, which contains four major steps: autophagic ...
Liu Shizuo +4 more
doaj +2 more sources
Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.
PLoS ONE, 2021 Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates.
Golam T Saffi +6 more
doaj +1 more source
Orphanet Journal of Rare Diseases, 2021 Parents of children with severe inborn errors of metabolism frequently face stressful events related to the disease of their child and are consequently at high risk for developing parental posttraumatic stress disorder (PTSD).
Thirsa Conijn +3 more
doaj +1 more source
Lysosome transport as a function of lysosome diameter. [PDF]
PLoS ONE, 2014 Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along ...
Debjyoti Bandyopadhyay +4 more
doaj +1 more source
Scientific Reports, 2021 We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages,
Peggy Robinet +7 more
doaj +1 more source
The Trypanosoma cruzi enzyme TcGPXI is a glycosomal peroxidase and can be linked to trypanothione reduction by glutathione or tryparedoxin. [PDF]
, 2002 Trypanosoma cruzi glutathione-dependent peroxidase I (TcGPXI) can reduce fatty acid, phospholipid, and short chain organic hydroperoxides utilizing a novel redox cycle in which enzyme activity is linked to the reduction of trypanothione, a parasite ...
Bromley, Elizabeth V +5 more
core +4 more sources
ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
Nature Communications, 2021 In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear.
Nazmiye Özkan +9 more
doaj +1 more source
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion. [PDF]
PLoS ONE, 2012 Cancer cells invade by secreting enzymes that degrade the extracellular matrix and these are sequestered in lysosomal vesicles. In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor vacuolin-1 on ...
Yu Liu, Yijiang Zhou, Keqing Zhu
doaj +1 more source
A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion. [PDF]
PLoS ONE, 2016 Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in response to
Magdalena L Circu +7 more
doaj +1 more source