Results 1 to 10 of about 159,324 (248)
Spatio-temporal processes in autophagosome-lysosome fusion [PDF]
Macroautophagy/autophagy is a lysosome-dependent degradation process involved in cellular energy metabolism, recycling and quality control. Autophagy is a highly dynamic and precisely regulated process, which contains four major steps: autophagic ...
Liu S, Yan H, Diao J, Zhang S, Zhong Q.
europepmc +2 more sources
Reactive oxygen species prevent lysosome coalescence during PIKfyve inhibition.
Lysosomes are terminal, degradative organelles of the endosomal pathway that undergo repeated fusion-fission cycles with themselves, endosomes, phagosomes, and autophagosomes. Lysosome number and size depends on balanced fusion and fission rates.
Golam T Saffi +6 more
doaj +1 more source
Parents of children with severe inborn errors of metabolism frequently face stressful events related to the disease of their child and are consequently at high risk for developing parental posttraumatic stress disorder (PTSD).
Thirsa Conijn +3 more
doaj +1 more source
Lysosome transport as a function of lysosome diameter. [PDF]
Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along ...
Debjyoti Bandyopadhyay +4 more
doaj +1 more source
We have previously shown that the DBA/2J versus AKR/J mouse strain is associated with decreased autophagy-mediated lysosomal hydrolysis of cholesterol esters. Our objective was to determine differences in lysosome function in AKR/J and DBA/2J macrophages,
Peggy Robinet +7 more
doaj +1 more source
ER – lysosome contacts at a pre-axonal region regulate axonal lysosome availability
In neurons and other cells, contacts between organelles regulates function and subcellular organization, but the precise mechanisms and effects are unclear.
Nazmiye Özkan +9 more
doaj +1 more source
Inhibition of glioma cell lysosome exocytosis inhibits glioma invasion. [PDF]
Cancer cells invade by secreting enzymes that degrade the extracellular matrix and these are sequestered in lysosomal vesicles. In this study, the effects of the selective lysosome lysing drug GPN and the lysosome exocytosis inhibitor vacuolin-1 on ...
Yu Liu, Yijiang Zhou, Keqing Zhu
doaj +1 more source
A Novel High Content Imaging-Based Screen Identifies the Anti-Helminthic Niclosamide as an Inhibitor of Lysosome Anterograde Trafficking and Prostate Cancer Cell Invasion. [PDF]
Lysosome trafficking plays a significant role in tumor invasion, a key event for the development of metastasis. Previous studies from our laboratory have demonstrated that the anterograde (outward) movement of lysosomes to the cell surface in response to
Magdalena L Circu +7 more
doaj +1 more source
Background Rare diseases are often un- or misdiagnosed for extended periods, resulting in a long diagnostic delay that may significantly add to the burden of the disease.
Gé-Ann Kuiper +3 more
doaj +1 more source
Simvastatin improves lysosome function via enhancing lysosome biogenesis in endothelial cells
Nlrp3 inflammasomes were shown to play a critical role in triggering obesity-associated early onsets of cardiovascular complications such as endothelial barrier dysfunction with endothelial hyperpermeability.
Youzhi Zhang +5 more
doaj +1 more source

