Results 61 to 70 of about 249,586 (383)

Lysosome trafficking is necessary for EGF-driven invasion and is regulated by p38 MAPK and Na+/H+ exchangers

BMC Cancer, 2017
Background Tumor invasion through a basement membrane is one of the earliest steps in metastasis, and growth factors, such as Epidermal Growth Factor (EGF) and Hepatocyte Growth Factor (HGF), stimulate this process in a majority of solid tumors. Basement
Samantha S. Dykes, Joshua J. Steffan, James A. Cardelli   +2 more
doaj   +1 more source

Enhancement of lysosome biogenesis as a potential therapeutic approach for neurodegenerative diseases

Neural Regeneration Research, 2023
Millions of people are suffering from Alzheimer’s disease globally, but there is still no effective treatment for this neurodegenerative disease. Thus, novel therapeutic approaches for Alzheimer’s disease are needed, which requires further evaluation of ...
Wenlong Xue, Jie Zhang, Yang Li
doaj   +1 more source

A dual-labeling probe to track functional mitochondria–lysosome interactions in live cells

Nature Communications, 2020
Mitochondria–lysosome interactions are essential for maintaining intracellular homeostasis. Although various fluorescent probes have been developed to visualize such interactions, they remain unable to label mitochondria and lysosomes simultaneously and ...
Qixin Chen, Hongbao Fang, Xintian Shao, Zhiqi Tian, Shan-shan Geng, Yuming Zhang, Huaxun Fan, Pan Xiang, Jie Zhang, Xiaohe Tian, Kai Zhang, Weijiang He, Zijian Guo, Jiajie Diao   +13 more
semanticscholar   +1 more source

Inhibition of Lysosome Membrane Recycling Causes Accumulation of Gangliosides that Contribute to Neurodegeneration

Cell Reports, 2018
Summary: Lysosome membrane recycling occurs at the end of the autophagic pathway and requires proteins that are mostly encoded by genes mutated in neurodegenerative diseases. However, its implication in neuronal death is still unclear. Here, we show that
Maxime Boutry, Julien Branchu, Céline Lustremant, Claire Pujol, Julie Pernelle, Raphaël Matusiak, Alexandre Seyer, Marion Poirel, Emeline Chu-Van, Alexandre Pierga, Kostantin Dobrenis, Jean-Philippe Puech, Catherine Caillaud, Alexandra Durr, Alexis Brice, Benoit Colsch, Fanny Mochel, Khalid Hamid El Hachimi, Giovanni Stevanin, Frédéric Darios   +19 more
doaj   +1 more source

Merkel cell polyomavirus large T antigen disrupts lysosome clustering by translocating human Vam6p from the cytoplasm to the nucleus [PDF]

, 2011
Merkel cell polyomavirus (MCV) has been recently described as the cause for most human Merkel cell carcinomas. MCV is similar to simian virus 40 (SV40) and encodes a nuclear large T (LT) oncoprotein that is usually mutated to eliminate viral replication ...
Ali, Binda, Campbell, Campbell, Caplan, Cotsiki, Côté-Martin, DeCaprio, Dilworth, Felici, Feng, Flinn, Hakki, Houben, Jennifer Hein, Lane, Laude, Li, Liang, Linzer, Mannová, Nakamura, Nakamura, Ole V. Gjoerup, Pallas, Patrick S. Moore, Pelkmans, Per H. Basse, Peralta, Pipas, Poupon, Price, Qian, Richardson, Schowalter, Shuda, Shuda, Simon C.W. Richardson, Srinivasan, Sukarieh, Tuna Toptan, Whitman, Wrana, Wurmser, Xi Liu, Yuan Chang   +45 more
core   +2 more sources

Identification of active natural products that induce lysosomal biogenesis by lysosome-based screening and biological evaluation

Heliyon, 2022
Lysosomal biogenesis is an essential adaptive process by which lysosomes exert their function in maintaining cellular homeostasis. Defects in lysosomal enzymes and functions lead to lysosome-related diseases, including lysosomal storage diseases and ...
Xiao Ding, Xu Yang, Yueqin Zhao, Yinyuan Wang, Jimin Fei, Zhenpeng Niu, Xianxiang Dong, Xuenan Wang, Biao Liu, Hongmei Li, Xiaojiang Hao, Yuhan Zhao   +11 more
doaj   +1 more source

CemOrange2 fusions facilitate multifluorophore subcellular imaging in C. elegans [PDF]

, 2019
Due to its ease of genetic manipulation and transparency, Caenorhabditis elegans (C. elegans) has become a preferred model system to study gene function by microscopy.
Buland, Justin R, Chou, Wendy Y. Y., Cole, F. Sessions, Dawson, Zachary, Homayouni, Airelle, Huang, Huiyan, Jia, Hanna, Kim, Hyori, Luke, Cliff J, Moreno, Marco, Pak, Stephen C, Silverman, Gary A, Thomas, Brian J, Wambach, Jennifer A, Wright, Ira E   +14 more
core   +3 more sources

Euphejolkinolide A, a new ent-abietane lactone from Euphorbia peplus L. with promising biological activity in activating the autophagy-lysosomal pathway

Heliyon, 2023
A new ent-abietane diterpenoid, named Euphejolkinolide A (1), was isolated from the whole plant of Euphorbia peplus L. Its structure, including absolute configurations, was determined by spectroscopic analyses and was corroborated by single-crystal X-ray
Xiaoqian Ran, Qing-Yun Lu, Ying-Yao Li, Xue-Xue Pu, Yarong Guo, Ming-Rui Yuan, Shi-Peng Guan, Mao Sun, Lijin Jiao, Yong-Gang Yao, Ying-Tong Di, Xiao-Jiang Hao, Rongcan Luo   +12 more
doaj   +1 more source

TRAF2 binds to TIFA via a novel motif and contributes to its autophagic degradation

FEBS Letters, EarlyView.
TRAF family members couple receptor signalling complexes to downstream outputs, but how they interact with these complexes is not always clear. Here, we show that during ADP‐heptose signalling, TRAF2 binding to TIFA requires two short sequence motifs in the C‐terminal tail of TIFA, which are distinct from the TRAF6 binding motif.
Tom Snelling, Kodi Hunter, Celest W. S. Tay, Nicola T. Wood, Philip Cohen   +4 more
wiley   +1 more source

Peripheral positioning of lysosomes supports melanoma aggressiveness. [PDF]

Nat Commun
Emerging evidence suggests that the function and position of organelles are pivotal for tumor cell dissemination. Among them, lysosomes stand out as they integrate metabolic sensing with gene regulation and secretion of proteases. Yet, how their function
Jerabkova-Roda K, Peralta M, Huang KJ, Mousson A, Bourgeat Maudru C, Bochler L, Busnelli I, Karali R, Justiniano H, Lisii LM, Carl P, Mittelheisser V, Asokan N, Larnicol A, Lefebvre O, Lachuer H, Pichot A, Stemmelen T, Molitor A, Scheid L, Frenger Q, Gros F, Hirschler A, Delalande F, Sick E, Carapito R, Carapito C, Lipsker D, Schauer K, Rondé P, Hyenne V, Goetz JG.   +31 more
europepmc   +2 more sources