Results 31 to 40 of about 231,146 (358)

Inhibition of NAADP signalling on reperfusion protects the heart by preventing lethal calcium oscillations via two-pore channel 1 and opening of the mitochondrial permeability transition pore [PDF]

, 2015
Aims In the heart, a period of ischaemia followed by reperfusion evokes powerful cytosolic Ca2+ oscillations that can cause lethal cell injury. These signals represent attractive cardioprotective targets, but the underlying mechanisms of genesis are ill ...
A. Ganesan, Derek M. Yellon, Jacobson, Kirsty Foote, Michael R. Duchen, Noah Tan, Raj Gosain, Richard Graeff, Richard Tyser, Sandip Patel, Sean M. Davidson, Siegmund, Suma Kunuthur, Yong Juan Zhao   +13 more
core   +1 more source

The Biogenesis of Lysosomes and Lysosome-Related Organelles [PDF]

Cold Spring Harbor Perspectives in Biology, 2014
Lysosomes were once considered the end point of endocytosis, simply used for macromolecule degradation. They are now recognized to be dynamic organelles, able to fuse with a variety of targets and to be re-formed after fusion events. They are also now known to be the site of nutrient sensing and signaling to the cell nucleus. In addition, lysosomes are
Yvonne Hackmann, Nele M. G. Dieckmann, Gillian M. Griffiths, J. Paul Luzio   +3 more
openaire   +2 more sources

Differential Internalization of Thrombin-Derived Host Defense Peptides into Monocytes and Macrophages

Journal of Innate Immunity, 2021
Proteolytic cleavage of thrombin generates C-terminal host defense peptides exerting multiple immunomodulatory effects in response to bacterial stimuli.
Finja C. Hansen, Aftab Nadeem, Kathryn L. Browning, Mario Campana, Artur Schmidtchen, Mariena J.A. van der Plas   +5 more
doaj   +1 more source

Real-time visualization of clustering and intracellular transport of gold nanoparticles by correlative imaging. [PDF]

, 2017
Mechanistic understanding of the endocytosis and intracellular trafficking of nanoparticles is essential for designing smart theranostic carriers. Physico-chemical properties, including size, clustering and surface chemistry of nanoparticles regulate ...
Chen, Nan, Fan, Chunhai, Lal, Ratnesh, Lee, Joon, Li, Jiajun, Li, Jiang, Li, Qian, Liang, Le, Liu, Mengmeng, Lv, Min, Shi, Jiye, Song, Haiyun, Wang, Kun, Wang, Lihua   +13 more
core   +2 more sources

Nanoplastics: From tissue accumulation to cell translocation into Mytilus galloprovincialis hemocytes. resilience of immune cells exposed to nanoplastics and nanoplastics plus Vibrio splendidus combination [PDF]

, 2020
Plastic litter is an issue of global concern. In this work Mytilus galloprovincialis was used to study the distribution and effects of polystyrene nanoplastics (PS NPs) of different sizes (50 nm, 100 nm and 1 mu m) on immune cells.
Figueras, A., Novoa, B., Romero, A., Saco, A., Sendra, M., Yeste Sigüenza, María del Pilar   +5 more
core   +1 more source

Aging-Related Changes in the Ultrastructure of Hepatocytes and Cardiomyocytes of Elderly Mice Are Enhanced in ApoE-Deficient Animals

Cells, 2021
Biological aging is associated with various morphological and functional changes, yet the mechanisms of these phenomena remain unclear in many tissues and organs. Hyperlipidemia is among the factors putatively involved in the aging of the liver and heart.
Małgorzata Łysek-Gładysińska, Anna Wieczorek, Artur Jóźwik, Anna Walaszczyk, Karol Jelonek, Grażyna Szczukiewicz-Markowska, Olaf K. Horbańczuk, Monika Pietrowska, Piotr Widłak, Dorota Gabryś   +9 more
doaj   +1 more source

Proteomics of the lysosome

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2009
Defects in lysosomal function have been associated with numerous monogenic human diseases typically classified as lysosomal storage diseases. However, there is increasing evidence that lysosomal proteins are also involved in more widespread human diseases including cancer and Alzheimer disease.
Torben Lübke, David E. Sleat, David E. Sleat, Peter Lobel, Peter Lobel   +4 more
openaire   +3 more sources

The TSC Complex-mTORC1 Axis: From Lysosomes to Stress Granules and Back

Frontiers in Cell and Developmental Biology, 2021
The tuberous sclerosis protein complex (TSC complex) is a key integrator of metabolic signals and cellular stress. In response to nutrient shortage and stresses, the TSC complex inhibits the mechanistic target of rapamycin complex 1 (mTORC1) at the ...
Ulrike Rehbein, Mirja Tamara Prentzell, Mirja Tamara Prentzell, Marti Cadena Sandoval, Marti Cadena Sandoval, Alexander Martin Heberle, Alexander Martin Heberle, Elizabeth P. Henske, Christiane A. Opitz, Christiane A. Opitz, Kathrin Thedieck, Kathrin Thedieck, Kathrin Thedieck   +12 more
doaj   +1 more source

The activation of KSHV lytic cycle blocks autophagy in PEL cells [PDF]

, 2015
This study confirms that autophagy is activated concomitantly with KSHV lytic cycle induction, and that autophagy inhibition by BECN1 knockdown reduces viral lytic gene expression.
CIRONE, Mara, FAGGIONI, Alberto, FARINA, Antonella, Filardi, M, GONNELLA, ROBERTA, GRANATO, Marisa, SANTARELLI, Roberta, TORRISI, Maria Rosaria   +7 more
core   +1 more source

Lysosome Transport as a Function of Lysosome Diameter

PLoS ONE, 2014
Lysosomes are membrane-bound organelles responsible for the transport and degradation of intracellular and extracellular cargo. The intracellular motion of lysosomes is both diffusive and active, mediated by motor proteins moving lysosomes along microtubules. We sought to determine how lysosome diameter influences lysosome transport.
Christine K. Payne, Jairo Zapata, Y. Joseph Kim, Austin Joseph Cyphersmith, Debjyoti Bandyopadhyay   +4 more
openaire   +5 more sources