Results 21 to 30 of about 26,398 (197)

Characterization of Recombinant Lysyl Oxidase Propeptide [PDF]

Biochemistry, 2010
Lysyl oxidase enzyme activity is critical for the biosynthesis of mature and functional collagens and elastin. In addition, lysyl oxidase has tumor suppressor activity that has been shown to depend on the propeptide region (LOX-PP) derived from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme activity.
Siddharth R, Vora, Ying, Guo, Danielle N, Stephens, Erdjan, Salih, Emile D, Vu, Kathrin H, Kirsch, Gail E, Sonenshein, Philip C, Trackman   +7 more
openaire   +2 more sources

Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy [PDF]

, 2015
Pancreatic ductal adenocarcinoma (PDAC) is one of the leading causes of cancer‐related mortality. Despite significant advances made in the treatment of other cancers, current chemotherapies offer little survival benefit in this disease ...
Amy Au, Andrew Biankin, Bryan W Miller, Caroline Springer, Christopher Ross Carter, Colin McKay, Colin Steele, David Chang, Emma Shanks, Ewan McGhee, Grazia Saturno, Janine T Erler, Jennifer P Morton, Joshua Leach, Karin Oien, Kurt Anderson, Lynn McGarry, Mark Pinese, Nigel B Jamieson, Owen J Sansom, Paul Timpson, Peter Bailey, Richard Marais, Saadia Karim, Thomas R Jeffry Evans, Timpson P   +25 more
core   +2 more sources

Vascular lysyl oxidase over-expression alters extracellular matrix structure and induces oxidative stress [PDF]

, 2018
Lysyl oxidase (LOX) participates in the assembly of collagen and elastin fibres. The impact of vascular LOX over-expression on extracellular matrix (ECM) structure and its contribution to oxidative stress has been analysed. Methods Studies were conducted
Briones, Ana M., García-Redondo, Ana B., Martínez-González, Jose, Rodríguez, Cristina, Salaíces, Mercedes, Varona, Saray   +5 more
core   +1 more source

Origin and evolution of lysyl oxidases [PDF]

Scientific Reports, 2015
AbstractLysyl oxidases (LOX) are copper-dependent enzymes that oxidize primary amine substrates to reactive aldehydes. The best-studied role of LOX enzymes is the remodeling of the extracellular matrix (ECM) in animals by cross-linking collagens and elastin, although intracellular functions have been reported as well.
Xavier Grau-Bové, Iñaki Ruiz-Trillo, Fernando Rodriguez-Pascual   +2 more
openaire   +3 more sources

Neural regulation of cancer: from mechanobiology to inflammation. [PDF]

, 2016
Despite recent progress in cancer research, the exact nature of malignant transformation and its progression is still not fully understood. Particularly metastasis, which accounts for most cancer death, is a very complex process, and new treatment ...
Kim, Tae-Hyung, Rowat, Amy C, Sloan, Erica K   +2 more
core   +2 more sources

Association between a common missense variant in LOXL3 gene and the risk of non-syndromic cleft palate [PDF]

, 2018
To investigate possible association between functional common variants in the lysyl oxidase like 3 gene and non-syndromic cleft palate we selected a common missense variant p.Ile615Phe (rs17010021), which was predicted to have a probably damaging effect ...
Andreasi, Rita Bassi, Bonsi, Martina, Khan, Mohammad Faisal Jamal, Little, Julian, Mossey, Peter, Rubini, Michele, Steegers-Theunissen, Regine P. M.   +6 more
core   +2 more sources

Tissue Engineered Human Elastic Cartilage From Primary Auricular Chondrocytes for Ear Reconstruction

Advanced Functional Materials, EarlyView.
Despite over three decades of research, no tissue‐engineered solution for auricular reconstruction in microtia patients has reached clinical translation. The key challenge lies in generating functional elastic cartilage ex vivo. Here, we integrate synergistic cell‐biomaterial strategies to engineer auricular grafts with mechanical and histological ...
Philipp Fisch, Sandra Kessler, Simone Ponta, Anna Puiggalí‐Jou, Guoliang Lyu, Killian Flégeau, Anastasiya Martyts, Florian Roth, David Fercher, Filippo M. Rijli, Daniel Simmen, Eva Novoa Olivares, Thomas Linder, Marcy Zenobi‐Wong   +13 more
wiley   +1 more source

Impact of treatment on myocardial lysyl oxidase expression and collagen cross-linking in patients with heart failure [PDF]

, 2009
The aim of this study was to investigate whether torasemide modifies collagen cross-linking in the failing human heart. We analyzed the degree of cross-linking and the expression of the enzyme lysyl oxidase, which regulates cross-linking, in the ...
Beaumont, J. (Javier), Diez-Martinez, J. (Javier), Gonzalez, A. (Arantxa), Larman, M. (Mariano), Lopez-Salazar, M.B. (María Begoña), Querejeta, R. (Ramón)   +5 more
core  

α5β1-Integrin promotes tension-dependent mammary epithelial cell invasion by engaging the fibronectin synergy site. [PDF]

, 2017
Tumors are fibrotic and characterized by abundant, remodeled, and cross-linked collagen that stiffens the extracellular matrix stroma. The stiffened collagenous stroma fosters malignant transformation of the tissue by increasing tumor cell tension to ...
Cassereau, L, García, AJ, Gooch, KJ, Hannachi, E-I, Miroshnikova, YA, Mouw, JK, Ou, G, Pickup, M, Rozenberg, GI, Sarang-Sieminski, AL, Templeman, KL, Weaver, VM   +11 more
core   +2 more sources

The Terminal Domains of Collagen‐Like Silk Direct Molecular Interactions and Liquid–Liquid Phase Separation‐Mediated Material Assembly

Advanced Functional Materials, EarlyView.
Terminal domains of recombinant collagen‐like silk regulate hierarchical self‐assembly across molecular and material scales. We show that terminal domains of collagen‐like silk enhance triple‐helix stability and drive liquid–liquid phase separation, enabling reversible formation of fibers and self‐healing films.
Mengjie Shen, Daniil Astapov, Nur Alia Oktaviani, Mami Goto, Keiji Numata, A. Sesilja Aranko   +5 more
wiley   +1 more source