Results 111 to 120 of about 2,643 (172)

GNA33 from Neisseria meningitidis serogroup B encodes a membrane-bound lytic transglycosylase (MltA)

, 2002
In a previous study, we used the genome of serogroup B Meningococcus to identify novel vaccine candidates. One of these molecules, GNA33, is well conserved among Meningococcus B strains, other Meningococcus serogroups and Gonococcus and induces ...
Ursinus, A., Grandi, G., Nicholas, R. A., Höltje, J., Nicholas, R., Kast, T., Savino, S., Arico, B., Baldi, L., Holtje, J. V., Rappuoli, R., Ursinus, A. ; https://orcid.org/, Jennings, G. T., Jennings, G., Marchetti, E.   +14 more
core   +1 more source

Bacillus subtilis CwlQ (previous YjbJ) is a bifunctional enzyme exhibiting muramidase and soluble-lytic transglycosylase activities [PDF]

, 2010
CwIQ (previous YjbJ) is one of the putative cell wall hydrolases in Bacillus subtilis. Its domain has an amino acid sequence similar to the soluble-lytic transglycosylase (SLT) of Escherichia coli Slt70 and also goose lysozyme (muramidase).
Junichi Sekiguchi, Tatsuya Fukushima, Sekiguchi, Junichi, Sudiarta, I. Putu, I Putu Sudiarta, Fukushima, Tatsuya   +5 more
core   +1 more source

Periplasmic crowding and peptidoglycan hydrolase activity as drivers of outer membrane vesiculation in Acinetobacter baumannii

Communications Biology
Acinetobacter baumannii produces outer membrane vesicles (OMVs) to alleviate envelope stress, though the mechanisms remain poorly understood. To induce periplasmic accumulation of misfolded proteins and trigger stress, a degP mutant is exposed to ...
Bitnara Kim, Yongjun Son, Reagan Lee, Jihyeon Min, Woojun Park   +4 more
doaj   +1 more source

Amber-codon suppression for spatial localization and in vivo photoaffinity capture of the interactome of the Pseudomonas aeruginosa rare lipoprotein A lytic transglycosylase. [PDF]

Protein Sci, 2023
Avila-Cobian LF, Hoshino H, Horsman ME, Nguyen VT, Qian Y, Feltzer R, Kim C, Hu DD, Champion MM, Fisher JF, Mobashery S.   +10 more
europepmc   +1 more source

Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa

, 2016
A family of 11 lytic transglycosylases in Pseudomonas aeruginosa, an opportunistic human pathogen, turn over the polymeric bacterial cell wall in the course of its recycling, repair, and maturation. The functions of these enzymes are not fully understood.
Juan A. Hermoso (1326768), Mijoon Lee (1336056), Kiran V. Mahasenan (1285209), Elena Lastochkin (1336074), Shahriar Mobashery (475725), Teresa Domínguez-Gil (2603590), Dusan Hesek (1336062)   +6 more
core   +1 more source

Prevalence and mechanisms of high-level carbapenem antibiotic tolerance in clinical isolates of Klebsiella pneumoniae.

PLoS Pathogens
Antibiotic tolerance is the ability of bacteria to survive normally lethal doses of antibiotics for extended time periods. Clinically significant Enterobacterales, for example, can exhibit high tolerance to the last-resort antibiotic meropenem. Meropenem
Trevor Cross, Facundo Torres, Nadia Nikulin, Abigail P McGee, Leena Jalees, Rhea Balakrishnan, Tolani Aliyu, Lars F Westblade, Abhyudai Singh, Tobias Dörr   +9 more
doaj   +1 more source

Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli

, 1997
Lytic transglycosylases are a unique lysozyme-like class of murein hydrolases believed to be important for growth of Escherichia coli. A membrane-bound lytic transglycosylase with an apparent molecular mass of 38 kDa, which was designated Mlt38, has ...
Vollmer, W. ; https://orcid.org/, Lommatzsch, J., Höltje, J., Templin, M., Kraft, A.   +4 more
core   +1 more source

Exploring the inhibition of the soluble lytic transglycosylase Cj0843c of Campylobacter jejuni via targeting different sites with different scaffolds. [PDF]

Protein Sci, 2023
Kumar V, Boorman J, Greenlee WJ, Zeng X, Lin J, van den Akker F.   +5 more
europepmc   +1 more source

Lytic Transglycosylases: Untangling Misconceptions in Bacterial Cell Wall Dynamics

, 2021
168 pages ; The bacterial cell wall comprises a strong, covalently closed network of peptidoglycan (PG) strands. While PG synthesis is generally essential for bacterial survival, the cell wall is also by necessity a dynamic structure and undergoes constant degradation and remodeling by “autolysins,” enzymes that break bonds within PG.
openaire   +2 more sources

Cleave a Septum, Leave a Cell: Bdellovibrio bacteriovorus Secretes a Specialized Lytic Transglycosylase to Clear Prey Cell Septum Obstruction. [PDF]

J Bacteriol, 2023
Dörr T.
europepmc   +1 more source