Results 131 to 140 of about 2,643 (172)

Lytic transglycosylase repertoire diversity enables intrinsic antibiotic resistance and daughter cell separation in Escherichia coli under acidic stress. [PDF]

Antimicrob Agents Chemother
Son JE, Park SH, Choi U, Lee C-R.
europepmc   +1 more source

Development of a method to generate a soluble substrate for lytic transglycosylases

, 2011
Peptidoglycan, the major component of the bacterial cell wall, is essential for cell viability. Several important antibiotics disrupt peptidoglycan metabolism, including the β-lactams and vancomycin. There are several bacterial enzymes involved in peptidoglycan metabolism that are not yet the target of antibiotics, such as the lytic transglycosylases ...
openaire   +1 more source

Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold

Lytic transglycosylases are bacterial enzymes involved in the maintenance and growth of the bacterial cell-wall peptidoglycan. They cleave the β-(1,4)-glycosidic bonds in peptidoglycan forming non-reducing 1,6-anhydromuropeptides.
Vollmer W, van Straaten KE, Thunnissen AMWH, Dijkstra BW   +3 more
core  

The lytic transglycosylase MltB connects membrane homeostasis and in vivo fitness of Acinetobacter baumannii. [PDF]

Mol Microbiol, 2018
Crépin S, Ottosen EN, Peters K, Smith SN, Himpsl SD, Vollmer W, Mobley HLT.   +6 more
europepmc   +1 more source

Mechanism of the Escherichia coli MltE lytic transglycosylase, the cell-wall-penetrating enzyme for Type VI secretion system assembly. [PDF]

Sci Rep, 2018
Byun B, Mahasenan KV, Dik DA, Marous DR, Speri E, Kumarasiri M, Fisher JF, Hermoso JA, Mobashery S.   +8 more
europepmc   +1 more source

Outer membrane localization of murein hydrolases: MltA, a third lipoprotein lytic transglycosylase in Escherichia coli

Lytic transglycosylases are a unique lysozyme-like class of murein hydrolases believed to be important for growth of Escherichia coli. A membrane-bound lytic transglycosylase with an apparent molecular mass of 38 kDa, which was designated Mlt38, has ...
Vollmer W, Templin MF, Lommatzsch J, Höltje J-V, Kraft AR   +4 more
core  

A step-by-step in crystallo guide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase. [PDF]

J Biol Chem, 2018
Williams AH, Wheeler R, Rateau L, Malosse C, Chamot-Rooke J, Haouz A, Taha MK, Boneca IG.   +7 more
europepmc   +1 more source

Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. [PDF]

Structure, 2016
Domínguez-Gil T, Lee M, Acebrón-Avalos I, Mahasenan KV, Hesek D, Dik DA, Byun B, Lastochkin E, Fisher JF, Mobashery S, Hermoso JA.   +10 more
europepmc   +1 more source

The Predicted Lytic Transglycosylase HpaH from Xanthomonas campestris pv. vesicatoria Associates with the Type III Secretion System and Promotes Effector Protein Translocation. [PDF]

Infect Immun, 2017
Hausner J, Hartmann N, Jordan M, Büttner D.   +3 more
europepmc   +1 more source