Results 91 to 100 of about 4,476 (193)

Mycobacteriophage endolysins: diverse and modular enzymes with multiple catalytic activities. [PDF]

PLoS ONE, 2012
The mycobacterial cell wall presents significant challenges to mycobacteriophages--viruses that infect mycobacterial hosts--because of its unusual structure containing a mycolic acid-rich mycobacterial outer membrane attached to an arabinogalactan layer ...
Kimberly M Payne, Graham F Hatfull
doaj   +1 more source

Identification of a New Family of Enzymes with Potential \u3cem\u3eO\u3c/em\u3e-acetylpeptidoglycan esterase activity in both Gram-positive and Gram-negative bacteria [PDF]

, 2005
Background: The metabolism of the rigid bacterial cell wall heteropolymer peptidoglycan is a dynamic process requiring continuous biosynthesis and maintenance involving the coordination of both lytic and synthetic enzymes.
Clarke, Anthony J., Pfeffer, John M., Weadge, Joel T.   +2 more
core   +1 more source

Lytic activity of the virion-associated peptidoglycan hydrolase HydH5 of bacteriophage vB_SauS-phiIPLA88 [PDF]

, 2011
Background Staphylococcus aureus is a food-borne pathogen and the most common cause of infections in hospitalized patients. The increase in the resistance of this pathogen to antibacterials has made necessary the development of
Lorena Rodríguez, Beatriz Martínez, Yuan Zhou, Ana Rodríguez, David M Donovan, Pilar García   +5 more
core   +1 more source

Navigating Host Immunity and Concurrent Ozone Stress: Strain‐Resolved Metagenomics Reveals Maintenance of Intraspecific Diversity and Genetic Variation in Xanthomonas on Pepper

Evolutionary Applications, Volume 18, Issue 1, January 2025.
ABSTRACT The evolving threat of new pathogen variants in the face of global environmental changes poses a risk to a sustainable crop production. Predicting and responding to how climate change affects plant‐pathosystems is challenging, as environment affects host–pathogen interactions from molecular to the community level, and with eco‐evolutionary ...
Amanpreet Kaur, Ivory Russell, Ranlin Liu, Auston Holland, Rishi Bhandari, Neha Potnis   +5 more
wiley   +1 more source

Structural Analysis of PlyKp104, a Novel Phage Endoysin

Crystals
Antibiotic resistance has emerged as a critical global public health challenge, prompting increased interest in non-antibiotic antimicrobial strategies such as bacteriophage-derived endolysins.
Jung-Min Choi
doaj   +1 more source

Specificity determinants for lysine incorporation in staphylococcus aureus peptidoglycan as revealed by the structure of a MurE enzyme ternary complex [PDF]

, 2013
Background: MurE controls stereo chemical incorporation of Lysine or diaminopimelate into peptidoglycan stem peptides Results: The structure of S.aureus MurE reveals an unexpected lack of specificity for Lysine within the active site.
Barreteau, Basavannacharya, Basavannacharya, Battye, Bertrand, Bertrand, Boniface, Boniface, Bouhss, Brünger, Bugg, Bugg, Chen, Clancy, Clarke, Clarke, Collaborative Computational Project, Number 4, Cox, Cressina, Crouvoisier, Cruickshank, De Lencastre, DeLano, Emsley, Ernst, Ernst, Favini-Stabile, Figueiredo, Gardete, Girardin, Gordon, Gorrec, Huber, Hutton, Jones, Kabsch, Lee, Liebeke, Lloyd, Lloyd, Lundqvist, Lysenko, Matteï, McCoy, Mei, Mengin-Lecreulx, Mengin-Lecreulx, Mohammadi, Murshudov, Münch, Ornelas-Soares, Painter, Paradis-Bleau, Paradis-Bleau, Patin, Perdih, Ray, Read, Royet, Sauvage, Scheffers, Schneider, Schouten, Smith, Sosič, Sova, Thedieck, Vagin, Vollmer, Vollmer, Walker, Young, Zawadzke   +72 more
core   +2 more sources

Modulation of the lytic apparatus by the FtsEX complex within the bacterial division machinery

FEBS Letters, Volume 598, Issue 23, Page 2836-2851, December 2024.
Conformational changes involved in the mechano‐transmission activation of the lytic machinery by FtsEX. This model is based on the Gram‐negative bacterium Pseudomonas aeruginosa, highlighting the EnvC protein that facilitates the activation of the lytic enzyme AmiB during cell division.
Martín Alcorlo, Siseth Martínez‐Caballero, Jianwei Li, Lok‐To Sham, Min Luo, Juan A. Hermoso   +5 more
wiley   +1 more source

Purification and properties of a membrane-bound lytic transglycosylase from Escherichia coli [PDF]

Journal of Bacteriology, 1994
A membrane-bound lytic transglycosylase (Mlt) has been solubilized in the presence of 2% Triton X-100 containing 0.5 M NaCl from membranes of an Escherichia coli mutant that carries a deletion in the slt gene coding for a 70-kDa soluble lytic transglycosylase (Slt70).
Ursinus, A. ; https://orcid.org/0009-0005-4319-2991, Höltje, J.   +1 more
openaire   +3 more sources

Structure of MltG from Mycobacterium abscessus reveals structural plasticity between composed domains

IUCrJ
MltG, a membrane-bound lytic transglycosylase, has roles in terminating glycan polymerization in peptidoglycan and incorporating glycan chains into the cell wall, making it significant in bacterial cell-wall biosynthesis and remodeling.
Gwan Hee Lee, Subin Kim, Do Yeon Kim, Ju Hee Han, So Yeon Lee, Jun Hyuck Lee, Chang Sup Lee, Hyun Ho Park   +7 more
doaj   +1 more source

Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria. [PDF]

PLoS Pathogens, 2010
Bacterial cell growth and division require coordinated cell wall hydrolysis and synthesis, allowing for the removal and expansion of cell wall material. Without proper coordination, unchecked hydrolysis can result in cell lysis.
Erik C Hett, Michael C Chao, Eric J Rubin   +2 more
doaj   +1 more source