Results 91 to 100 of about 2,643 (172)

Interaction and modulation of two antagonistic cell wall enzymes of mycobacteria. [PDF]

PLoS Pathogens, 2010
Bacterial cell growth and division require coordinated cell wall hydrolysis and synthesis, allowing for the removal and expansion of cell wall material. Without proper coordination, unchecked hydrolysis can result in cell lysis.
Erik C Hett, Michael C Chao, Eric J Rubin   +2 more
doaj   +1 more source

In Vivo Cross‐Linking Sheds Light on the Salmonella Divisome in Which PBP3 and PBP3SAL Compete for Occupancy

Molecular Microbiology, Volume 122, Issue 5, Page 797-818, November 2024.
Salmonella encodes two peptidoglycan synthases, PBP3 and PBP3SAL, which can promote cell division independently. This study shows by in vivo cross‐linking and proteomics that PBP3 and PBP3SAL do not interact in the division complex and that ~40 proteins may associate direct or indirectly to these enzymes, including expected divisome components and new ...
Sónia Castanheira, David López‐Escarpa, Alberto Paradela, Francisco García‐del Portillo   +3 more
wiley   +1 more source

Breaking barriers: pCF10 type 4 secretion system relies on a self-regulating muramidase to modulate the cell wall

mBio
Conjugative type 4 secretion systems (T4SSs) are the main driver for the spread of antibiotic resistance genes and virulence factors in bacteria.
Wei-Sheng Sun, Gabriel Torrens, Josy ter Beek, Felipe Cava, Ronnie P.-A. Berntsson   +4 more
doaj   +1 more source

Reactions of All Escherichia coli Lytic Transglycosylases with Bacterial Cell Wall [PDF]

Journal of the American Chemical Society, 2013
The reactions of all seven Escherichia coli lytic transglycosylases with purified bacterial sacculus are characterized in a quantitative manner. These reactions, which initiate recycling of the bacterial cell wall, exhibit significant redundancy in the activities of these enzymes along with some complementarity.
Lee, Mijoon, Hesek, Dusan, Llarrull, Leticia Irene, Lastochkin, Elena, Pi, Hualiang, Boggess, Bill, Mobashery, Shahriar   +6 more
openaire   +3 more sources

Peptidoglycan Endopeptidase PBP7 Facilitates the Recruitment of FtsN to the Divisome and Promotes Peptidoglycan Synthesis in Escherichia coli

Molecular Microbiology, Volume 122, Issue 5, Page 743-756, November 2024.
The peptidoglycan (PG) hydrolase PBP7 localizes to both the lateral cell envelope and midcell in Escherichia coli, and its midcell localization is dependent on an active divisome. PBP7 influences the timing of FtsZ and FtsN assembly within the divisome. In the absence of PBP7, FtsN assembly is slower and septal PG synthesis is reduced in the absence of
Xinwei Liu, Gabriela Boelter, Waldemar Vollmer, Manuel Banzhaf, Tanneke den Blaauwen   +4 more
wiley   +1 more source

Bacterial extracellular vesicles as intranasal postbiotics: Detailed characterization and interaction with airway cells

Journal of Extracellular Vesicles, Volume 13, Issue 10, October 2024.
This study investigates Escherichia coli A0 34/86 (EcO83), a probiotic strain known for its ability to prevent infections and diarrhoea in newborns and reduce allergic airway inflammation in mice. Although live probiotic bacteria are effective, they also harbour certain risks, such as possible infection and gene transfer.
Agnieszka Razim, Agnieszka Zabłocka, Anna Schmid, Michael Thaler, Viktor Černý, Tamara Weinmayer, Bradley Whitehead, Anke Martens, Magdalena Skalska, Mattia Morandi, Katy Schmidt, Magdalena E. Wysmołek, Akos Végvári, Dagmar Srutkova, Martin Schwarzer, Lukas Neuninger, Peter Nejsum, Jiri Hrdý, Johan Palmfeldt, Marco Brucale, Francesco Valle, Sabina Górska, Lukas Wisgrill, Aleksandra Inic‐Kanada, Ursula Wiedermann, Irma Schabussova   +25 more
wiley   +1 more source

Toxin release mediated by the novel autolysin Cwp19 in Clostridium difficile

Microbial Cell, 2018
Clostridium difficile, also known as Clostriodioides difficile, is a Gram positive, spore-forming bacterium and a leading cause of antibiotic-associated diarrhea in nosocomial environments. The key virulence factors of this pathogen are two toxins, toxin
Imane El Meouche, Johann Peltier
doaj   +1 more source

Influence of microbiota on the growth and gene expression of Clostridioides difficile in an in vitro coculture model

MicrobiologyOpen, Volume 13, Issue 5, October 2024.
The presence of microbiota did not affect the growth of Clostridioides difficile in this study. However, it did influence the expression of C. difficile genes related to sporulation, germination, and virulence, which are crucial for the transmission of the pathogen. In the presence of microbiota, C.
Elisa Martinez, Noémie Berg, Cristina Rodriguez, Georges Daube, Bernard Taminiau   +4 more
wiley   +1 more source

MtrR Regulates a Major Lytic Transglycosylase (ltgA) Responsible for Peptidoglycan-Derived Cytotoxin Release and Autolysis in Neisseria gonorrhoeae

Microorganisms
The multiple-transferable resistance protein (MtrR) is a transcriptional repressor of the mtrCDE-encoded drug efflux pump and Type IV pilus biosynthesis (pilM), and an activator of penicillin-binding protein 1 (ponA) expression in Neisseria gonorrhoeae ...
Alaa I. Telchy, Tia Morgan, Kathleen T. Hackett, Ronald K. McMillan, Robert A. Nicholas, Joseph P. Dillard, Daniel Williams   +6 more
doaj   +1 more source

The Pathogenic Neisseria Use a Streamlined Set of Peptidoglycan Degradation Proteins for Peptidoglycan Remodeling, Recycling, and Toxic Fragment Release

Frontiers in Microbiology, 2019
Neisseria gonorrhoeae and Neisseria meningitidis release peptidoglycan (PG) fragments from the cell as the bacteria grow. For N. gonorrhoeae these PG fragments are known to cause damage to human Fallopian tube tissue in organ culture that mimics the ...
Ryan E. Schaub, Joseph P. Dillard
doaj   +1 more source