Results 81 to 90 of about 4,476 (193)

Environmental Antimicrobial Resistance: Key Drivers, Hotspots, Innovative Strategies, and Challenges in the Fight Against Superbugs

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Antimicrobial resistance (AMR) poses a critical threat to global health, affecting humans, animals, and the environment. This review explores major drivers and hotspots of AMR and outlines innovative strategies, including One Health–based interventions, to mitigate the spread of resistant pathogens and address this escalating worldwide health challenge.
Kindu Alem, Mulat Dagnew, Mucheye Gizachew, Baye Gelaw, Feleke Moges   +4 more
wiley   +1 more source

Small Things Matter: The 11.6-kDa TraB Protein is Crucial for Antibiotic Resistance Transfer Among Enterococci

Frontiers in Molecular Biosciences, 2022
Conjugative transfer is the most important means for spreading antibiotic resistance genes. It is used by Gram-positive and Gram-negative bacteria, and archaea as well.
Tamara M.I. Berger, Claudia Michaelis, Ines Probst, Theo Sagmeister, Lukas Petrowitsch, Sandra Puchner, Tea Pavkov-Keller, Tea Pavkov-Keller, Tea Pavkov-Keller, Bernd Gesslbauer, Elisabeth Grohmann, Walter Keller, Walter Keller, Walter Keller   +13 more
doaj   +1 more source

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa

mBio
Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can
Joël Gyger, Gabriel Torrens, Felipe Cava, Thomas G. Bernhardt, Coralie Fumeaux   +4 more
doaj   +1 more source

Genomic analysis of 48 paenibacillus larvae bacteriophages [PDF]

, 2018
Indexación: Scopus.Funding: Research at UNLV was funded by National Institute of General Medical Sciences grant GM103440 (NV INBRE), the UNLV School of Life Sciences, and the UNLV College of Sciences. E.C.-N.
Castro-Nallar, E., Fajardo, C.P., Grose, J.H., Hope, S., Mendez, K.N., Stamereilers, C., Tsourkas, P.K., Walker, J.K.   +7 more
core   +1 more source

Phage and Endolysin Therapy Against Antibiotics Resistant Bacteria: From Bench to Bedside

MedComm, Volume 6, Issue 7, July 2025.
Synergistic effects of combining bacteriophages and antibiotics in antimicrobial therapy. The diagram illustrates key advantages of phage‐antibiotic synergy, including increased treatment effectiveness, reduced minimum inhibitory concentration (MIC) for drug‐resistant strains, enhanced biofilm eradication, and inhibition of resistant bacteria ...
Majid Taati Moghadam, Samane Mohebi, Raheleh Sheikhi, Meysam Hasannejad‐Bibalan, Shahla Shahbazi, Shadman Nemati   +5 more
wiley   +1 more source

Neisseria gonorrhoeae Uses Two Lytic Transglycosylases To Produce Cytotoxic Peptidoglycan Monomers [PDF]

Journal of Bacteriology, 2008
ABSTRACT Peptidoglycan fragments released by Neisseria gonorrhoeae contribute to the inflammation and ciliated cell death associated with gonorrhea and pelvic inflammatory disease. However, little is known about the production and release of these fragments during bacterial growth.
Karen A, Cloud-Hansen, Kathleen T, Hackett, Daniel L, Garcia, Joseph P, Dillard   +3 more
openaire   +2 more sources

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source

Propionibacterium acnes bacteriophages display limited genetic diversity and broad killing activity against bacterial skin isolates. [PDF]

, 2012
UnlabelledInvestigation of the human microbiome has revealed diverse and complex microbial communities at distinct anatomic sites. The microbiome of the human sebaceous follicle provides a tractable model in which to study its dominant bacterial ...
Bowman, Charles, Cokus, Shawn, Fitz-Gibbon, Sorel, Hatfull, Graham F, Hayes, Clarmyra, Inkeles, Megan, Jacobs-Sera, Deborah, Kim, Jenny, Loncaric, Anya, Marinelli, Laura J, Miller, Jeff F, Modlin, Robert L, Pellegrini, Matteo, Russell, Daniel A   +13 more
core   +2 more sources

Phage‐derived proteins: Advancing food safety through biocontrol and detection of foodborne pathogens

Comprehensive Reviews in Food Science and Food Safety, Volume 24, Issue 2, March 2025.
Abstract The emergence of antimicrobial‐resistant foodborne pathogens poses a continuous health risk and economic burden as they can easily spread through contaminated food. Therefore, the demand for new antimicrobial agents to address this problem is steadily increasing.
Dahee Choi, Sangryeol Ryu, Minsuk Kong
wiley   +1 more source

Lytic Transglycosylases: Untangling Misconceptions in Bacterial Cell Wall Dynamics

, 2021
168 pages ; The bacterial cell wall comprises a strong, covalently closed network of peptidoglycan (PG) strands. While PG synthesis is generally essential for bacterial survival, the cell wall is also by necessity a dynamic structure and undergoes constant degradation and remodeling by “autolysins,” enzymes that break bonds within PG.
openaire   +2 more sources