Results 61 to 70 of about 2,643 (172)

Identification and characterization of a novel lytic peptidoglycan transglycosylase (MltC) in Shigella dysenteriae

Brazilian Journal of Microbiology, 2023
Shigellosis remains a worldwide health problem due to the lack of vaccines and the emergence of antibiotic-resistant strains. Shigella (S.) dysenteriae has rigid peptidoglycan (PG), and its tight regulation of biosynthesis and remodeling is essential for bacterial integrity.
Baleegh A Kadhim, Kawther Alqaseer, Sura A Al-Ganahi   +2 more
openaire   +2 more sources

The structure of a resuscitation-promoting factor domain from Mycobacterium tuberculosis shows homology to lysozymes

, 2005
Resuscitation-promoting factor (RPF) proteins reactivate stationary-phase cultures of (G+C)-rich Gram-positive bacteria including the causative agent of tuberculosis, Mycobacterium tuberculosis.
Nicholas H Keep, Barthe, P., John Ward, Philippe Barthe, Barthe, Philippe, Ward, J.M., Roumestand, Christian, Keep, Nicholas, Martin Cohen-Gonsaud, Ward, John, Henderson, Brian, Henderson, B., Cohen-Gonsaud, Martin, Keep, Nicholas H., Claire Bagnéris, Bagneris, Claire, Christian Roumestand, Roumestand, C., Cohen Gonsaud, M., Brian Henderson   +19 more
core   +1 more source

A Novel Salmonella Periplasmic Protein Controlling Cell Wall Homeostasis and Virulence

Frontiers in Microbiology, 2021
Horizontal gene transfer has shaped the evolution of Salmonella enterica as pathogen. Some functions acquired by this mechanism include enzymes involved in peptidoglycan (PG) synthesis and remodeling.
Juan J. Cestero, Sónia Castanheira, M. Graciela Pucciarelli, M. Graciela Pucciarelli, M. Graciela Pucciarelli, Francisco García-del Portillo   +5 more
doaj   +1 more source

Comprehensive and Comparative Transcriptional Profiling of the Cell Wall Stress Response in Bacillus subtilis

Molecular Microbiology, Volume 125, Issue 6, Page 506-545, June 2026.
Transcriptional profiling of the primary cell envelope stress response (CESR) of Bacillus subtilis exposed to a range of cell wall‐targeting antimicrobials, combining RNAseq and high‐resolution tiling arrays. We revealed the complexity of the CESR, the contribution of extracytoplasmic function sigma factors (ECFs) and two‐component signal transduction ...
Qian Zhang, Charlène Cornilleau, Lena Friebel, Sarah Spitzner, Raphael R. Müller, Doreen Meier, Pierre Flores, Cyprien Guérin, Pierre Nicolas, Diana Wolf, Vincent Fromion, Rut Carballido‐López, Thorsten Mascher   +12 more
wiley   +1 more source

Characterisation of a Novel Jumbo Lytic Aeromonas dhakensis Bacteriophage P19 and Its Endolysin

Microbial Biotechnology, Volume 19, Issue 1, January 2026.
A jumbo, lytic myovirus phage P19 against multidrug‐resistant (MDR) Aeromonas dhakensis was isolated from river water. P19 demonstrated robust lytic activity, high thermal and pH stability (pH 6–10, up to 60°C), and no genes associated with lysogeny, virulence or antimicrobial resistance. ORF_358 of P19 encodes for T4‐type lysozyme.
Farhat Ansari, Vandan Nagar
wiley   +1 more source

Secreted Glycoside Hydrolase BcGH61 From Botrytis cinerea Induces Cell Death by the Apoplastic Location and Triggers Intracellular Immune Perception

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
We present a dual‐action virulence paradigm for BcGH61: Extracellularly, BcGH61 glycoside hydrolase degrades cell walls, releasing DAMPs that activate PRR‐mediated cell death. Intracellularly, it targets chloroplasts via NbHrBP1 interaction at plastoglobule‐thylakoid interfaces, paradoxically activating defence signalling while priming immunity‐related
Wenjun Zhu, Ziyao Wang, Can Zheng, Min Fang, Binbin Huang, Xiaofei Nie, Yong Liang, Zhaoxia Li, Kai Bi   +8 more
wiley   +1 more source

The interplay between Acinetobacter baumannii ZigA and SltB promotes zinc homeostasis and cell envelope integrity

Infection and Immunity
Acinetobacter baumannii is an opportunistic human pathogen that acquires nutrient metals from the vertebrate host amid infection. During zinc (Zn) scarcity, A. baumannii upregulates the expression of the predicted Zn metallochaperone, zigA.
Jeanette M. Critchlow, Juan P. Barraza, Matthew J. Munneke, Evan Krystofiak, Erin R. Green, Eric P. Skaar   +5 more
doaj   +1 more source

Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Jibon Kumar Paul, Arzuba Akter, Nurnabi Azad Jewel, Mohimenul Haque Rolin, Daniyal Karim, Raphael Kabir Niloy, Shakhinur Islam Mondal   +6 more
wiley   +1 more source

Generation of Distinct Differentially Culturable Forms of Burkholderia following Starvation at Low Temperature

Microbiology Spectrum, 2022
Bacteria have developed unique mechanisms to adapt to environmental stresses and challenges of the immune system. Here, we report that Burkholderia pseudomallei, the causative agent of melioidosis, and its laboratory surrogate, Burkholderia thailandensis,
Joss M. Auty, Christopher H. Jenkins, Jennifer Hincks, Anna A. Straatman-Iwanowska, Natalie Allcock, Obolbek Turapov, Edouard E. Galyov, Sarah V. Harding, Galina V. Mukamolova   +8 more
doaj   +1 more source

Molecular Cloning and Functional Analysis of Holin and Endolysin From Escherichia Phage UE‐M6 as Potential Antibacterial Agents

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
We isolated phage UE‐M6 from wastewater and subsequently cloned, expressed, and purified its encoded endolysin (UE‐lysin) and holin (UE‐holin). Our results demonstrate that the combined application of UE‐lysin and UE‐holin exhibits significantly greater antibacterial activity than either protein alone, indicating a synergistic interaction between the ...
Hira Niaz, Mikael Skurnik, Fazal Adnan
wiley   +1 more source