Results 61 to 70 of about 2,299 (155)

A putative lytic transglycosylase tightly regulated and critical for the EHEC type three secretion

Journal of Biomedical Science, 2010
Open reading frame l0045 in the pathogenic island of enterohemorrhagic Escherichia coli O157:H7 has been predicted to encode a lytic transglycosylase that is homologous to two different gene products encoded by the same bacteria at loci away from the ...
Hu Wensi S, Ng Swee-Chuan, Wang Shao-Hung, Lin Ching-Nan, Yu Yen-Chi, Syu Wan-Jr   +5 more
doaj   +1 more source

Small Things Matter: The 11.6-kDa TraB Protein is Crucial for Antibiotic Resistance Transfer Among Enterococci

Frontiers in Molecular Biosciences, 2022
Conjugative transfer is the most important means for spreading antibiotic resistance genes. It is used by Gram-positive and Gram-negative bacteria, and archaea as well.
Tamara M.I. Berger, Claudia Michaelis, Ines Probst, Theo Sagmeister, Lukas Petrowitsch, Sandra Puchner, Tea Pavkov-Keller, Tea Pavkov-Keller, Tea Pavkov-Keller, Bernd Gesslbauer, Elisabeth Grohmann, Walter Keller, Walter Keller, Walter Keller   +13 more
doaj   +1 more source

Molecular Cloning and Functional Analysis of Holin and Endolysin From Escherichia Phage UE‐M6 as Potential Antibacterial Agents

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
We isolated phage UE‐M6 from wastewater and subsequently cloned, expressed, and purified its encoded endolysin (UE‐lysin) and holin (UE‐holin). Our results demonstrate that the combined application of UE‐lysin and UE‐holin exhibits significantly greater antibacterial activity than either protein alone, indicating a synergistic interaction between the ...
Hira Niaz, Mikael Skurnik, Fazal Adnan
wiley   +1 more source

The Vertebrate Lysozyme Inhibitor Ivy Functions to Inhibit the Activity of Lytic Transglycosylase [PDF]

Journal of Biological Chemistry, 2010
The proteinaceous inhibitor of vertebrate lysozymes (Ivy) is produced by a collection of Gram-negative bacteria as a stress response to damage to their essential cell wall component peptidoglycan. A paralog of Ivy, Ivyp2 is produced exclusively by a number of pseudomonads, including Pseudomonas aeruginosa, but this protein does not inhibit the ...
Chelsea A, Clarke, Edie M, Scheurwater, Anthony J, Clarke   +2 more
openaire   +2 more sources

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa

mBio
Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can
Joël Gyger, Gabriel Torrens, Felipe Cava, Thomas G. Bernhardt, Coralie Fumeaux   +4 more
doaj   +1 more source

Environmental Antimicrobial Resistance: Key Drivers, Hotspots, Innovative Strategies, and Challenges in the Fight Against Superbugs

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Antimicrobial resistance (AMR) poses a critical threat to global health, affecting humans, animals, and the environment. This review explores major drivers and hotspots of AMR and outlines innovative strategies, including One Health–based interventions, to mitigate the spread of resistant pathogens and address this escalating worldwide health challenge.
Kindu Alem, Mulat Dagnew, Mucheye Gizachew, Baye Gelaw, Feleke Moges   +4 more
wiley   +1 more source

Control of the activity of the soluble lytic transglycosylase by the stringent response in Escherichia coli [PDF]

FEMS Microbiology Letters, 1990
The soluble lytic transglycosylase (Slt) of Escherichia coli is known to be a powerful murein hydrolase in vitro. It is shown here to act as an autolysin in vivo as well. Rapid autolysis of Slt overproducing cells was induced by protein biosynthesis inhibitors, which also block the fomration of guanosine-5'-diphosphate-3'-diphosphate (ppGpp).
Betzner, A., Ferreira, L., Höltje, J., Keck, W.   +3 more
openaire   +3 more sources

Phage and Endolysin Therapy Against Antibiotics Resistant Bacteria: From Bench to Bedside

MedComm, Volume 6, Issue 7, July 2025.
Synergistic effects of combining bacteriophages and antibiotics in antimicrobial therapy. The diagram illustrates key advantages of phage‐antibiotic synergy, including increased treatment effectiveness, reduced minimum inhibitory concentration (MIC) for drug‐resistant strains, enhanced biofilm eradication, and inhibition of resistant bacteria ...
Majid Taati Moghadam, Samane Mohebi, Raheleh Sheikhi, Meysam Hasannejad‐Bibalan, Shahla Shahbazi, Shadman Nemati   +5 more
wiley   +1 more source

Deletion of Lytic Transglycosylases Increases Beta-Lactam Resistance in Shewanella oneidensis [PDF]

Frontiers in Microbiology, 2018
Production of chromosome-encoded β-lactamases confers resistance to β-lactams in many Gram-negative bacteria. Some inducible β-lactamases, especially the class C β-lactamase AmpC in Enterobacteriaceae, share a common regulatory mechanism, the ampR-ampC paradigm.
Jianhua Yin, Jianhua Yin, Jianhua Yin, Yiyang Sun, Yijuan Sun, Zhiliang Yu, Juanping Qiu, Haichun Gao   +7 more
openaire   +3 more sources

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source