mBioAcinetobacter baumannii is a Gram-negative opportunistic pathogen and is a common cause of nosocomial infections. The increasing development of antibiotic resistance in this organism is a global health concern. The A.
Valeriya Bezkorovayna +7 more
doaj +1 more source
Activation by Allostery in Cell-Wall Remodeling by a Modular Membrane-Bound Lytic Transglycosylase from Pseudomonas aeruginosa. [PDF]
Structure, 2016 Domínguez-Gil T +10 more
europepmc +2 more sources
Image-based dynamic phenotyping reveals genetic determinants of filamentation-mediated beta-lactam tolerance [PDF]
, 2020 Antibiotic tolerance characterized by slow killing of bacteria in response to a drug can lead to treatment failure and promote the emergence of resistance.
Camacho, Rafael +8 more
core +2 more sources
Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation [PDF]
Journal of Biological Chemistry, 2016 Bacterial spores are the most resistant form of life known on Earth and represent a serious problem for (i) bioterrorism attack, (ii) horizontal transmission of microbial pathogens in the community, and (iii) persistence in patients and in a nosocomial environment.
Salvatore, Nocadello +5 more
openaire +2 more sources
Microbial Cell Factories, 2022 Background Bacterial type III secretion systems (T3SSs) assemble a multiprotein complex termed the injectisome, which acts as a molecular syringe for translocation of specific effector proteins into the cytoplasm of host cells.
Beatriz Álvarez +3 more
doaj +1 more source
Reactions of All Escherichia coli Lytic Transglycosylases with Bacterial Cell Wall [PDF]
Journal of the American Chemical Society, 2013 The reactions of all seven Escherichia coli lytic transglycosylases with purified bacterial sacculus are characterized in a quantitative manner. These reactions, which initiate recycling of the bacterial cell wall, exhibit significant redundancy in the activities of these enzymes along with some complementarity.
Lee, Mijoon +6 more
openaire +3 more sources
A Novel Salmonella Periplasmic Protein Controlling Cell Wall Homeostasis and Virulence
Frontiers in Microbiology, 2021 Horizontal gene transfer has shaped the evolution of Salmonella enterica as pathogen. Some functions acquired by this mechanism include enzymes involved in peptidoglycan (PG) synthesis and remodeling.
Juan J. Cestero +5 more
doaj +1 more source
Structural and functional analysis of SleL, a peptidoglycan lysin involved in germination of Bacillus spores. [PDF]
, 2015 A major event in the germination of Bacillus spores concerns hydrolysis of the cortical peptidoglycan that surrounds the spore protoplast, the integrity of which is essential for maintenance of dormancy.
Chirgadze, Dimitri Y +2 more
core +1 more source
DUF3380 domain from a Salmonella phage endolysin shows potent N -acetylmuramidase activity [PDF]
, 2016 Bacteriophage-encoded endolysins are highly diverse enzymes that cleave the bacterial peptidoglycan layer. Current research focuses on their potential applications in medicine, in food conservation, and as biotechnological tools.
Hans Gerstmans +6 more
core +1 more source
Characterisation of a Novel Jumbo Lytic Aeromonas dhakensis Bacteriophage P19 and Its Endolysin
Microbial Biotechnology, Volume 19, Issue 1, January 2026.A jumbo, lytic myovirus phage P19 against multidrug‐resistant (MDR) Aeromonas dhakensis was isolated from river water. P19 demonstrated robust lytic activity, high thermal and pH stability (pH 6–10, up to 60°C), and no genes associated with lysogeny, virulence or antimicrobial resistance. ORF_358 of P19 encodes for T4‐type lysozyme.
Farhat Ansari, Vandan Nagar
wiley +1 more source