Results 41 to 50 of about 2,299 (155)

Subcellular localization and processing of the lytic transglycosylase of the conjugative plasmid R1 [PDF]

FEBS Letters, 2000
Protein P19 encoded by the conjugative resistance plasmid R1, is essential for efficient conjugative DNA transfer and infection by the pilus‐specific RNA phage R17. Based on sequence homologies P19 belongs to a family of lysozyme‐like virulence factors which are found in type III and type IV secretion systems.
Bayer, Michaela, Bischof, Karin, Noiges, Rainer, Koraimann, Günther   +3 more
openaire   +2 more sources

Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation [PDF]

Journal of Biological Chemistry, 2016
Bacterial spores are the most resistant form of life known on Earth and represent a serious problem for (i) bioterrorism attack, (ii) horizontal transmission of microbial pathogens in the community, and (iii) persistence in patients and in a nosocomial environment.
Salvatore, Nocadello, George, Minasov, Ludmilla S, Shuvalova, Ievgeniia, Dubrovska, Elisabetta, Sabini, Wayne F, Anderson   +5 more
openaire   +2 more sources

Characterization ofHelicobacter pyloriLytic Transglycosylases Slt and MltD [PDF]

Journal of Bacteriology, 2007
ABSTRACTPeptidoglycan (PG) is a cell wall heteropolymer that is essential for cell integrity. PG hydrolases participate in correct assembly of the PG layer and have been shown to be required for cell division, cell daughter separation, and maintenance of bacterial morphology. In silico analysis of theHelicobacter pylorigenome resulted in identification
Chaput, Catherine, Labigne, Agnès, Boneca, Ivo G   +2 more
openaire   +3 more sources

Pseudomonas syringae lytic transglycosylase HrpH interacts with host ubiquitin ligase ATL2 to modulate plant immunity

Cell Reports
Summary: Pseudomonas syringae deploys a type III secretion system (T3SS) to deliver effector proteins to facilitate infection of plant cells; however, little is known about the direct interactions between T3SS components and plants.
Jun-Zhou Li, Yi-Lin Gu, Wei Zhang, Shen Cong, Ruo-Na Wang, Yi-Nan Ma, Ya Jin, Hai-Lei Wei   +7 more
doaj   +1 more source

Lytic transglycosylase Slt of Pseudomonas aeruginosa as a periplasmic hub protein. [PDF]

Protein Sci
AbstractPeptidoglycan is a major constituent of the bacterial cell wall. Its integrity as a polymeric edifice is critical for bacterial survival and, as such, it is a preeminent target for antibiotics. The peptidoglycan is a dynamic crosslinked polymer that undergoes constant biosynthesis and turnover.
Avila-Cobian LF, De Benedetti S, Hoshino H, Nguyen VT, El-Araby AM, Sader S, Hu DD, Cole SL, Kim C, Fisher JF, Champion MM, Mobashery S.   +11 more
europepmc   +3 more sources

Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance β-Lactam antibiotics are currently the most broadly used class of antibiotics. These antibiotics prevent bacterial cell wall from cross-linking, which leads to the accumulation of long non–cross-linked strands of peptidoglycan.
Lee M, Batuecas MT, Tomoshige S, Domínguez-Gil T, Mahasenan KV, Dik DA, Hesek D, Millán C, Usón I, Lastochkin E, Hermoso JA, Mobashery S.   +11 more
europepmc   +5 more sources

The catalytic domain of a bacterial lytic transglycosylase defines a novel class of lysozymes [PDF]

Proteins: Structure, Function, and Bioinformatics, 1995
AbstractThe 70‐kDa soluble lytic transglycosylase (SLT70) from Escherichia coli is a bacterial exo‐muramidase that cleaves the cell wall peptidoglycan, producing 1,6‐anhydro‐muropeptides. The X‐ray structure of SLT70 showed that one of its domains is structurally related to lysozyme, although there is no obvious similarity in amino acid sequence.
Thunnissen, Andy-Mark W.H., Isaacs, Neil W., Dijkstra, Bauke W.   +2 more
openaire   +3 more sources

Delivery determinants of an Acinetobacter baumannii type VI secretion system bifunctional peptidoglycan hydrolase

mBio
Acinetobacter baumannii is a Gram-negative opportunistic pathogen and is a common cause of nosocomial infections. The increasing development of antibiotic resistance in this organism is a global health concern. The A.
Valeriya Bezkorovayna, Brooke K. Hayes, Francesca N. Gillett, Amy Wright, David I. Roper, Marina Harper, Sheena McGowan, John D. Boyce   +7 more
doaj   +1 more source

Bactericidal effect of nanostructures via lytic transglycosylases of Escherichia coli

RSC Advances, 2022
The time profiles of active cell ratios depended on the growth phase and the absence of some lytic transglycosylases of E. coli. Significant cell damage was not found on the autolysis inhibition condition.
Soma Mimura, Tomohiro Shimizu, Shoso Shingubara, Hiroaki Iwaki, Takeshi Ito   +4 more
openaire   +3 more sources

Enhanced protein translocation to mammalian cells by expression of EtgA transglycosylase in a synthetic injector E. coli strain

Microbial Cell Factories, 2022
Background Bacterial type III secretion systems (T3SSs) assemble a multiprotein complex termed the injectisome, which acts as a molecular syringe for translocation of specific effector proteins into the cytoplasm of host cells.
Beatriz Álvarez, Víctor Muñoz-Abad, Alejandro Asensio-Calavia, Luis Ángel Fernández   +3 more
doaj   +1 more source