Structural studies and molecular dynamics simulations suggest a processive mechanism of exolytic lytic transglycosylase from Campylobacter jejuni. [PDF]
PLoS ONE, 2018 The bacterial soluble lytic transglycosylase (LT) breaks down the peptidoglycan (PG) layer during processes such as cell division. We present here crystal structures of the soluble LT Cj0843 from Campylobacter jejuni with and without bulgecin A inhibitor
Jagamya Vijayaraghavan +6 more
doaj +2 more sources
Exolytic and endolytic turnover of peptidoglycan by lytic transglycosylase Slt of Pseudomonas aeruginosa. [PDF]
Proc Natl Acad Sci U S A, 2018 Significance β-Lactam antibiotics are currently the most broadly used class of antibiotics. These antibiotics prevent bacterial cell wall from cross-linking, which leads to the accumulation of long non–cross-linked strands of peptidoglycan.
Lee M +11 more
europepmc +5 more sources
Peptidoglycan recycling is critical for cell division, cell wall integrity, and β-lactam resistance in Caulobacter crescentus [PDF]
eLifeMost bacteria possess a peptidoglycan (PG) sacculus, which is continuously remodeled during cell growth and division. The turnover products generated in this process are typically imported into the cell and reused for PG biosynthesis.
Pia Richter +7 more
doaj +2 more sources
eLife, 2022 The peptidoglycan cell wall is a predominant structure of bacteria, determining cell shape and supporting survival in diverse conditions. Peptidoglycan is dynamic and requires regulated synthesis of new material, remodeling, and turnover – or autolysis –
Anna Isabell Weaver +7 more
doaj +1 more source
The Lytic Transglycosylases of Neisseria gonorrhoeae [PDF]
Microbial Drug Resistance, 2012 Neisseria gonorrhoeae encodes five lytic transglycosylases (LTs) in the core genome, and most gonococcal strains also carry the gonococcal genetic island that encodes one or two additional LTs. These peptidoglycan (PG)-degrading enzymes are required for a number of processes that are either involved in the ...
Yolande A, Chan +2 more
openaire +2 more sources
Biochemical and Phylogenetic Study of SltF, a Flagellar Lytic Transglycosylase from Rhodobacter sphaeroides [PDF]
Journal of Bacteriology, 2018 Javier De La Mora +2 more
exaly +2 more sources
Characterization of three different lytic transglycosylases inEscherichia coli [PDF]
FEMS Microbiology Letters, 1993 Two lytic transglycosylases, releasing 1,6-anhydromuropeptides from murein sacculi are present in a mutant deleted for the soluble lytic transglycosylase 70 (Slt70). Thus, there are three different lytic transglycosylases in Escherichia coli. One of the remaining enzymes is soluble and one is a membrane protein that can be solubilized by 2% Triton X ...
Romeis T, Vollmer W, Höltje J-V
openaire +6 more sources
Growth of Porphyromonas gingivalis on human serum albumin triggers programmed cell death
Journal of Oral Microbiology, 2023 Aims Gingival crevicular fluid (GCF) constitutes the primary growth substrate for Porphyromonas gingivalis in vivo. The goal of this work was to evaluate the growth of different strains of P.
Shirin Ghods +4 more
doaj +1 more source
Crystal structure and mechanism of the lytic transglycosylase MltA from Escherichia coli [PDF]
, 2006 This thesis describes the determination and analysis of the 3D-structure of the lytic transglycosylase MltA from Escherichia coli by X-ray crystallography.
van Straaten, Karin
core +4 more sources
Structure of the Bacteriophage φKZ Lytic Transglycosylase gp144 [PDF]
Journal of Biological Chemistry, 2008 Lytic transglycosylases are enzymes that act on the peptidoglycan of bacterial cell walls. They cleave the glycosidic linkage between N-acetylmuramoyl and N-acetylglucosaminyl residues with the concomitant formation of a 1,6-anhydromuramoyl product. The x-ray structure of the lytic transglycosylase gp144 from the Pseudomonas bacteriophage phi KZ has ...
Andrei, Fokine +4 more
openaire +2 more sources