Structural Characterization of Lytic Transglycosylase SltB2 of Pseudomonas aeruginosa [PDF]
ACS OmegaLytic transglycosylases (LTs) belong to a family of enzymes that turnover the bacterial cell-wall peptidoglycan through a nonhydrolytic cleavage of the β(1-4) glycosidic bond, generating a hallmark 1,6-anhydromuramyl moiety in the reaction products.
Vega Miguel-Ruano +6 more
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Exploitation of a Bacterium-Encoded Lytic Transglycosylase by a Human Oral Lytic Phage To Facilitate Infection [PDF]
Journal of Virology, 2022 The evidence for the presence of a diverse and abundant phage population in the host-associated oral microbiome came largely from metagenomic analysis or the observation of virus-like particles within saliva/plaque samples, while the isolation of oral phage and investigation of their interaction with bacterial hosts are limited.
Jeffrey S Mclean +2 more
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Bulgecin A: The Key to a Broad‐Spectrum Inhibitor That Targets Lytic Transglycosylases [PDF]
Antibiotics, 2017 Lytic transglycosylases (Lts) are involved in recycling, cell division, and metabolism of the peptidoglycan. They have been understudied for their usefulness as potential antibacterial targets due to their high redundancy in Gram‐negative bacteria ...
Allison H. Williams +5 more
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Soluble lytic transglycosylase SLT of Francisella novicida is involved in intracellular growth and immune suppression. [PDF]
PLoS ONE, 2019 Francisella tularensis, a category-A bioterrorism agent causes tularemia. F. tularensis suppresses the immune response of host cells and intracellularly proliferates.
Takemasa Nakamura +4 more
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Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in
mBio, 2018 Clostridium difficile is the major etiologic agent of antibiotic-associated intestinal disease. Pathogenesis of C. difficile is mainly attributed to the production and secretion of toxins A and B.
Sandra Wydau-Dematteis +11 more
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Important role of a putative lytic transglycosylase Cj0843c in β-lactam resistance in Campylobacter jejuni [PDF]
Frontiers in Microbiology, 2015 Beta-lactam antibiotics are an important class of antibiotics for treating bacterial infections. Despite prevalent β-lactam resistance in Campylobacter jejuni, the leading bacterial cause of human diarrhea in developed countries, molecular mechanism of β-
Ximin eZeng +2 more
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Glycan strand cleavage by a lytic transglycosylase, MltD contributes to the expansion of peptidoglycan in Escherichia coli. [PDF]
PLoS GeneticsPeptidoglycan (PG) is a protective sac-like exoskeleton present in most bacterial cell walls. It is a large, covalently crosslinked mesh-like polymer made up of many glycan strands cross-bridged to each other by short peptide chains.
Moneca Kaul +3 more
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Structural insights into MltB from Acinetobacter baumannii: a conserved catalytic tunnel with unique domain arrangement [PDF]
IUCrJLytic transglycosylases (LTs) play a central role in bacterial cell wall remodeling by cleaving the β-1,4-glycosidic bond in peptidoglycan via a non-hydrolytic mechanism, producing 1,6-anhydroMurNAc termini crucial for recycling and signaling. Among LTs,
Hyunseok Jang +3 more
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Structural studies and molecular dynamics simulations suggest a processive mechanism of exolytic lytic transglycosylase from Campylobacter jejuni. [PDF]
PLoS ONE, 2018 The bacterial soluble lytic transglycosylase (LT) breaks down the peptidoglycan (PG) layer during processes such as cell division. We present here crystal structures of the soluble LT Cj0843 from Campylobacter jejuni with and without bulgecin A inhibitor
Jagamya Vijayaraghavan +6 more
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A Francisella novicida Mutant, Lacking the Soluble Lytic Transglycosylase Slt, Exhibits Defects in Both Growth and Virulence [PDF]
Frontiers in Microbiology, 2019 Francisella tularensis is the causative agent of tularemia and has gained recent interest as it poses a significant biothreat risk. F. novicida is commonly used as a laboratory surrogate for tularemia research due to genetic similarity and susceptibility
Beth A. Bachert +12 more
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