Structural Characterization of Lytic Transglycosylase SltB2 of Pseudomonas aeruginosa [PDF]
ACS OmegaPeer ...
Vega Miguel-Ruano +6 more
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Lytic transglycosylases mitigate periplasmic crowding by degrading soluble cell wall turnover products [PDF]
eLife, 2022 The peptidoglycan cell wall is a predominant structure of bacteria, determining cell shape and supporting survival in diverse conditions. Peptidoglycan is dynamic and requires regulated synthesis of new material, remodeling, and turnover – or autolysis –
Anna Isabell Weaver +7 more
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Inhibition of membrane‐bound lytic transglycosylase B by NAG‐thiazoline
FEBS Letters, 2004 The lytic transglycosylases cleave the bacterial cell wall heteropolymer peptidoglycan with the same specificity as the muramidases (lysozymes), between the N‐acetylmuramic acid and N‐acetylglucosamine residues, with the concomitant formation of a 1,6‐anhydromuramoyl residue.
Reid, Christopher W. +4 more
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Soluble lytic transglycosylase SLT of Francisella novicida is involved in intracellular growth and immune suppression. [PDF]
PLoS ONE, 2019 Francisella tularensis, a category-A bioterrorism agent causes tularemia. F. tularensis suppresses the immune response of host cells and intracellularly proliferates.
Takemasa Nakamura +4 more
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Cwp19 Is a Novel Lytic Transglycosylase Involved in Stationary-Phase Autolysis Resulting in Toxin Release in
mBio, 2018 Clostridium difficile is the major etiologic agent of antibiotic-associated intestinal disease. Pathogenesis of C. difficile is mainly attributed to the production and secretion of toxins A and B.
Sandra Wydau-Dematteis +11 more
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Glycan strand cleavage by a lytic transglycosylase, MltD contributes to the expansion of peptidoglycan in Escherichia coli. [PDF]
PLoS GeneticsPeptidoglycan (PG) is a protective sac-like exoskeleton present in most bacterial cell walls. It is a large, covalently crosslinked mesh-like polymer made up of many glycan strands cross-bridged to each other by short peptide chains.
Moneca Kaul +3 more
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Important role of a putative lytic transglycosylase Cj0843c in β-lactam resistance in Campylobacter jejuni [PDF]
Frontiers in Microbiology, 2015 Beta-lactam antibiotics are an important class of antibiotics for treating bacterial infections. Despite prevalent β-lactam resistance in Campylobacter jejuni, the leading bacterial cause of human diarrhea in developed countries, molecular mechanism of β-
Ximin eZeng +2 more
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Bulgecin A: The Key to a Broad‐Spectrum Inhibitor That Targets Lytic Transglycosylases [PDF]
Antibiotics, 2017 Lytic transglycosylases (Lts) are involved in recycling, cell division, and metabolism of the peptidoglycan. They have been understudied for their usefulness as potential antibacterial targets due to their high redundancy in Gram‐negative bacteria ...
Allison H. Williams +5 more
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A Francisella novicida Mutant, Lacking the Soluble Lytic Transglycosylase Slt, Exhibits Defects in Both Growth and Virulence [PDF]
Frontiers in Microbiology, 2019 Francisella tularensis is the causative agent of tularemia and has gained recent interest as it poses a significant biothreat risk. F. novicida is commonly used as a laboratory surrogate for tularemia research due to genetic similarity and susceptibility
Beth A. Bachert +12 more
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Crystal Structure of MltA from Escherichia coli Reveals a Unique Lytic Transglycosylase Fold [PDF]
Journal of Molecular Biology, 2005 Lytic transglycosylases are bacterial enzymes involved in the maintenance and growth of the bacterial cell-wall peptidoglycan. They cleave the beta-(1,4)-glycosidic bonds in peptidoglycan forming non-reducing 1,6-anhydromuropeptides. The crystal structure of the lytic transglycosylase MltA from Escherichia coli without a membrane anchor was solved at 2.
van Straaten KE +3 more
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