Peptidoglycan recycling is critical for cell division, cell wall integrity, and β-lactam resistance in Caulobacter crescentus [PDF]
eLifeMost bacteria possess a peptidoglycan (PG) sacculus, which is continuously remodeled during cell growth and division. The turnover products generated in this process are typically imported into the cell and reused for PG biosynthesis.
Pia Richter +7 more
doaj +2 more sources
EloR interacts with the lytic transglycosylase MltG at midcell in Streptococcus pneumoniae R6. [PDF]
J Bacteriol, 2021 Abstract The ellipsoid shape of Streptococcus pneumoniae is determined by the synchronized actions of the elongasome and the divisome, which have the task of creating a protective layer of peptidoglycan (PG) enveloping the cell membrane.
Winther AR +4 more
europepmc +5 more sources
X-ray Structure of Catenated Lytic Transglycosylase SltB1. [PDF]
Biochemistry, 2017 Formation of catenanes by proteins is rare, with few known examples. We report herein the X-ray structure of a catenane dimer of lytic transglycosylase SltB1 of Pseudomonas aeruginosa. The enzyme is soluble and exists in the periplasmic space, where it modifies the bacterial cell wall.
Domínguez-Gil T +5 more
europepmc +5 more sources
eLife, 2022 The peptidoglycan cell wall is a predominant structure of bacteria, determining cell shape and supporting survival in diverse conditions. Peptidoglycan is dynamic and requires regulated synthesis of new material, remodeling, and turnover – or autolysis –
Anna Isabell Weaver +7 more
doaj +1 more source
The Lytic Transglycosylases of Neisseria gonorrhoeae [PDF]
Microbial Drug Resistance, 2012 Neisseria gonorrhoeae encodes five lytic transglycosylases (LTs) in the core genome, and most gonococcal strains also carry the gonococcal genetic island that encodes one or two additional LTs. These peptidoglycan (PG)-degrading enzymes are required for a number of processes that are either involved in the ...
Yolande A, Chan +2 more
openaire +2 more sources
Biochemical and Phylogenetic Study of SltF, a Flagellar Lytic Transglycosylase from Rhodobacter sphaeroides [PDF]
Journal of Bacteriology, 2018 Georges Dreyfus +2 more
exaly +2 more sources
Characterization of three different lytic transglycosylases inEscherichia coli [PDF]
FEMS Microbiology Letters, 1993 Two lytic transglycosylases, releasing 1,6-anhydromuropeptides from murein sacculi are present in a mutant deleted for the soluble lytic transglycosylase 70 (Slt70). Thus, there are three different lytic transglycosylases in Escherichia coli. One of the remaining enzymes is soluble and one is a membrane protein that can be solubilized by 2% Triton X ...
Romeis T, Vollmer W, Höltje J-V
openaire +7 more sources
Growth of Porphyromonas gingivalis on human serum albumin triggers programmed cell death
Journal of Oral Microbiology, 2023 Aims Gingival crevicular fluid (GCF) constitutes the primary growth substrate for Porphyromonas gingivalis in vivo. The goal of this work was to evaluate the growth of different strains of P.
Shirin Ghods +4 more
doaj +1 more source
Structure of the Bacteriophage φKZ Lytic Transglycosylase gp144 [PDF]
Journal of Biological Chemistry, 2008 Lytic transglycosylases are enzymes that act on the peptidoglycan of bacterial cell walls. They cleave the glycosidic linkage between N-acetylmuramoyl and N-acetylglucosaminyl residues with the concomitant formation of a 1,6-anhydromuramoyl product. The x-ray structure of the lytic transglycosylase gp144 from the Pseudomonas bacteriophage phi KZ has ...
Andrei, Fokine +4 more
openaire +2 more sources
The mechanistic landscape of Lytic transglycosylase as targets for antibacterial therapy
Current Opinion in Structural Biology, 2022 Lytic transglycosylases (Ltgs) are glycan strand cleaving enzymes whose role is poorly understood in the genesis of the bacterial envelope. They play multiple roles in all stages of a bacterial life cycle, by creating holes in the peptidoglycan that is necessary for cell division and separation.
Elizabeth A. Martinez-Bond +2 more
openaire +2 more sources