Results 51 to 60 of about 2,643 (172)

Structural and functional characterisation of a lytic transglycosylase and two ω-transaminases [PDF]

, 2015
This thesis describes the determination and analysis of 3D-structures of enzymes from two different enzyme classes, the lytic transglycosylase MltF from Pseudomonas aeruginosa and two ω-transaminases, an (R)-selective transaminase from an Arthrobacter ...
Reddem, Eswarreddy
core   +4 more sources

BB0259 Encompasses a Peptidoglycan Lytic Enzyme Function for Proper Assembly of Periplasmic Flagella in Borrelia burgdorferi

Frontiers in Microbiology, 2021
Assembly of the bacterial flagellar rod, hook, and filament requires penetration through the peptidoglycan (PG) sacculus and outer membrane. In most β- and γ-proteobacteria, the protein FlgJ has two functional domains that enable PG hydrolyzing activity ...
Hui Xu, Bo Hu, David A. Flesher, David A. Flesher, Jun Liu, Jun Liu, Md A. Motaleb   +6 more
doaj   +1 more source

Subcellular localization and processing of the lytic transglycosylase of the conjugative plasmid R1 [PDF]

FEBS Letters, 2000
Protein P19 encoded by the conjugative resistance plasmid R1, is essential for efficient conjugative DNA transfer and infection by the pilus‐specific RNA phage R17. Based on sequence homologies P19 belongs to a family of lysozyme‐like virulence factors which are found in type III and type IV secretion systems.
Bayer, Michaela, Bischof, Karin, Noiges, Rainer, Koraimann, Günther   +3 more
openaire   +2 more sources

Crystal Structures of the SpoIID Lytic Transglycosylases Essential for Bacterial Sporulation [PDF]

Journal of Biological Chemistry, 2016
Bacterial spores are the most resistant form of life known on Earth and represent a serious problem for (i) bioterrorism attack, (ii) horizontal transmission of microbial pathogens in the community, and (iii) persistence in patients and in a nosocomial environment.
Salvatore, Nocadello, George, Minasov, Ludmilla S, Shuvalova, Ievgeniia, Dubrovska, Elisabetta, Sabini, Wayne F, Anderson   +5 more
openaire   +2 more sources

Characterization ofHelicobacter pyloriLytic Transglycosylases Slt and MltD [PDF]

Journal of Bacteriology, 2007
ABSTRACTPeptidoglycan (PG) is a cell wall heteropolymer that is essential for cell integrity. PG hydrolases participate in correct assembly of the PG layer and have been shown to be required for cell division, cell daughter separation, and maintenance of bacterial morphology. In silico analysis of theHelicobacter pylorigenome resulted in identification
Chaput, Catherine, Labigne, Agnès, Boneca, Ivo G   +2 more
openaire   +3 more sources

Turnover of Bacterial Cell Wall by SltB3, a Multidomain Lytic Transglycosylase of Pseudomonas aeruginosa. [PDF]

ACS Chem Biol, 2016
A family of 11 lytic transglycosylases in Pseudomonas aeruginosa, an opportunistic human pathogen, turn over the polymeric bacterial cell wall in the course of its recycling, repair, and maturation. The functions of these enzymes are not fully understood.
Lee M, Domínguez-Gil T, Hesek D, Mahasenan KV, Lastochkin E, Hermoso JA, Mobashery S.   +6 more
europepmc   +2 more sources

Structure and cell wall cleavage by modular lytic transglycosylase MltC of Escherichia coli. [PDF]

ACS Chem Biol, 2014
© 2014 American Chemical Society. The lytic transglycosylases are essential bacterial enzymes that catalyze the nonhydrolytic cleavage of the glycan strands of the bacterial cell wall. We describe here the structural and catalytic properties of MltC, one
Artola-Recolons C, Lee M, Bernardo-García N, Blázquez B, Hesek D, Bartual SG, Mahasenan KV, Lastochkin E, Pi H, Boggess B, Meindl K, Usón I, Fisher JF, Mobashery S, Hermoso JA.   +14 more
europepmc   +2 more sources

Delivery determinants of an Acinetobacter baumannii type VI secretion system bifunctional peptidoglycan hydrolase

mBio
Acinetobacter baumannii is a Gram-negative opportunistic pathogen and is a common cause of nosocomial infections. The increasing development of antibiotic resistance in this organism is a global health concern. The A.
Valeriya Bezkorovayna, Brooke K. Hayes, Francesca N. Gillett, Amy Wright, David I. Roper, Marina Harper, Sheena McGowan, John D. Boyce   +7 more
doaj   +1 more source

Bactericidal effect of nanostructures via lytic transglycosylases of Escherichia coli

RSC Advances, 2022
The time profiles of active cell ratios depended on the growth phase and the absence of some lytic transglycosylases of E. coli. Significant cell damage was not found on the autolysis inhibition condition.
Soma Mimura, Tomohiro Shimizu, Shoso Shingubara, Hiroaki Iwaki, Takeshi Ito   +4 more
openaire   +3 more sources

Enhanced protein translocation to mammalian cells by expression of EtgA transglycosylase in a synthetic injector E. coli strain

Microbial Cell Factories, 2022
Background Bacterial type III secretion systems (T3SSs) assemble a multiprotein complex termed the injectisome, which acts as a molecular syringe for translocation of specific effector proteins into the cytoplasm of host cells.
Beatriz Álvarez, Víctor Muñoz-Abad, Alejandro Asensio-Calavia, Luis Ángel Fernández   +3 more
doaj   +1 more source