Results 71 to 80 of about 2,643 (172)

A putative lytic transglycosylase tightly regulated and critical for the EHEC type three secretion

Journal of Biomedical Science, 2010
Open reading frame l0045 in the pathogenic island of enterohemorrhagic Escherichia coli O157:H7 has been predicted to encode a lytic transglycosylase that is homologous to two different gene products encoded by the same bacteria at loci away from the ...
Hu Wensi S, Ng Swee-Chuan, Wang Shao-Hung, Lin Ching-Nan, Yu Yen-Chi, Syu Wan-Jr   +5 more
doaj   +1 more source

Environmental Antimicrobial Resistance: Key Drivers, Hotspots, Innovative Strategies, and Challenges in the Fight Against Superbugs

MicrobiologyOpen, Volume 14, Issue 5, October 2025.
Antimicrobial resistance (AMR) poses a critical threat to global health, affecting humans, animals, and the environment. This review explores major drivers and hotspots of AMR and outlines innovative strategies, including One Health–based interventions, to mitigate the spread of resistant pathogens and address this escalating worldwide health challenge.
Kindu Alem, Mulat Dagnew, Mucheye Gizachew, Baye Gelaw, Feleke Moges   +4 more
wiley   +1 more source

A potential space-making role in cell wall biogenesis for SltB1and DacB revealed by a beta-lactamase induction phenotype in Pseudomonas aeruginosa

mBio
Pseudomonas aeruginosa encodes the beta-lactamase AmpC, which promotes resistance to beta-lactam antibiotics. Expression of ampC is induced by anhydro-muropeptides (AMPs) released from the peptidoglycan (PG) cell wall upon beta-lactam treatment. AmpC can
Joël Gyger, Gabriel Torrens, Felipe Cava, Thomas G. Bernhardt, Coralie Fumeaux   +4 more
doaj   +1 more source

Small Things Matter: The 11.6-kDa TraB Protein is Crucial for Antibiotic Resistance Transfer Among Enterococci

Frontiers in Molecular Biosciences, 2022
Conjugative transfer is the most important means for spreading antibiotic resistance genes. It is used by Gram-positive and Gram-negative bacteria, and archaea as well.
Tamara M.I. Berger, Claudia Michaelis, Ines Probst, Theo Sagmeister, Lukas Petrowitsch, Sandra Puchner, Tea Pavkov-Keller, Tea Pavkov-Keller, Tea Pavkov-Keller, Bernd Gesslbauer, Elisabeth Grohmann, Walter Keller, Walter Keller, Walter Keller   +13 more
doaj   +1 more source

The C-terminal Domain of Escherichia coli YfhD Functions as a Lytic Transglycosylase [PDF]

Journal of Biological Chemistry, 2008
The hypothetical Escherichia coli protein YfhD has been identified as the archetype for the family 1B lytic transglycosylases despite a complete lack of experimental characterization. The yfhD gene was amplified from the genomic DNA of E. coli W3110 and cloned to encode a fusion protein with a C-terminal His(6) sequence.
Edie M, Scheurwater, Anthony J, Clarke
openaire   +2 more sources

An atypical orphan carbohydrate-NRPS genomic island encodes a novel lytic transglycosylase. [PDF]

Chem Biol, 2014
SummaryMicrobial genome sequencing platforms have produced a deluge of orphan biosynthetic pathways suspected of biosynthesizing new small molecules with pharmacological relevance. Genome synteny analysis provides an assessment of genomic island content,
Guo X, Crawford JM.
europepmc   +2 more sources

The Vertebrate Lysozyme Inhibitor Ivy Functions to Inhibit the Activity of Lytic Transglycosylase [PDF]

Journal of Biological Chemistry, 2010
The proteinaceous inhibitor of vertebrate lysozymes (Ivy) is produced by a collection of Gram-negative bacteria as a stress response to damage to their essential cell wall component peptidoglycan. A paralog of Ivy, Ivyp2 is produced exclusively by a number of pseudomonads, including Pseudomonas aeruginosa, but this protein does not inhibit the ...
Chelsea A, Clarke, Edie M, Scheurwater, Anthony J, Clarke   +2 more
openaire   +2 more sources

Phage and Endolysin Therapy Against Antibiotics Resistant Bacteria: From Bench to Bedside

MedComm, Volume 6, Issue 7, July 2025.
Synergistic effects of combining bacteriophages and antibiotics in antimicrobial therapy. The diagram illustrates key advantages of phage‐antibiotic synergy, including increased treatment effectiveness, reduced minimum inhibitory concentration (MIC) for drug‐resistant strains, enhanced biofilm eradication, and inhibition of resistant bacteria ...
Majid Taati Moghadam, Samane Mohebi, Raheleh Sheikhi, Meysam Hasannejad‐Bibalan, Shahla Shahbazi, Shadman Nemati   +5 more
wiley   +1 more source

MUREIN-METABOLIZING ENZYMES FROM ESCHERICHIA-COLI - EXISTENCE OF A 2ND LYTIC TRANSGLYCOSYLASE

, 1992
In addition to the soluble lytic transglycosylase, a murein-metabolizing enzyme with a molecular mass of 70 kDa (Slt70), Escherichia coli possesses a second lytic transglycosylase, which has been described as a membrane-bound lytic transglycosylase (Mlt;
ENGEL, H, VANWIJNGAARDEN, L, KECK, W, SMINK, AJ   +3 more
core   +1 more source

Fighting Antimicrobial Resistance: Innovative Drugs in Antibacterial Research

Angewandte Chemie International Edition, Volume 64, Issue 10, March 3, 2025.
This article provides an overview over antibacterial drugs investigated in the past three decades. Aspects of the compound's origins, their cellular targets, the antibacterial spectrum and proof‐of‐concept in animal studies are covered and current trends are highlighted.
Roderich D. Süssmuth, Marcel Kulike‐Koczula, Peng Gao, Simone Kosol   +3 more
wiley   +1 more source