Results 71 to 80 of about 4,476 (193)

Substrate-Assisted Catalysis Unifies Two Families of Chitinolytic Enzymes [PDF]

, 1997
Hen egg-white lysozyme has long been the paradigm for enzymatic glycosyl hydrolysis with retention of configuration, with a protonated carboxylic acid and a deprotonated carboxylate participating in general acid-base catalysis.
Blake C. C. F., C−, Davies G. J., Ford L. O., Henrissat B., Iseli B., Johnson L. N., Jones T. A., Kirby A., Knapp S., Kobayashi S., Koshland D. E., Perrakis A., Phillips D. C., Piszkiewicz D., Rao V. H., Rozeboom H. J., Sinnot M. L., Strynadka N. C. J., Sulzenbacher G., Terwisscha van Scheltinga A. C., Terwisscha van Scheltinga A. C., Terwisscha van Scheltinga A. C., Tews I., Thunnissen A. M. W. H., Tronrud D. E., van Roey P., Vårum K. M., Weaver L. H.   +28 more
core   +3 more sources

Secreted Glycoside Hydrolase BcGH61 From Botrytis cinerea Induces Cell Death by the Apoplastic Location and Triggers Intracellular Immune Perception

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
We present a dual‐action virulence paradigm for BcGH61: Extracellularly, BcGH61 glycoside hydrolase degrades cell walls, releasing DAMPs that activate PRR‐mediated cell death. Intracellularly, it targets chloroplasts via NbHrBP1 interaction at plastoglobule‐thylakoid interfaces, paradoxically activating defence signalling while priming immunity‐related
Wenjun Zhu, Ziyao Wang, Can Zheng, Min Fang, Binbin Huang, Xiaofei Nie, Yong Liang, Zhaoxia Li, Kai Bi   +8 more
wiley   +1 more source

Cell wall peptidoglycan in Mycobacterium tuberculosis: An Achilles’ heel for the TB-causing pathogen [PDF]

, 2019
Tuberculosis (TB), caused by the intracellular pathogen Mycobacterium tuberculosis, remains one of the leading causes of mortality across the world. There is an urgent requirement to build a robust arsenal of effective antimicrobials, targeting novel ...
Bhakta, S, Healy, J, Keep, NH, Maitra, A, Martin, LT, Munshi, TK, Vollmer, W   +6 more
core   +2 more sources

Exploration of Human Skin Phageome to Reveal Endolysins and Novel Antimicrobial Peptides for Therapeutic Applications

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
This study uncovers diverse endolysins and novel antimicrobial peptides from the human skin phageome, highlighting their potential to target antibiotic‐resistant pathogens and disrupt virulence mechanisms, paving the way for next‐generation skin therapeutics.
Jibon Kumar Paul, Arzuba Akter, Nurnabi Azad Jewel, Mohimenul Haque Rolin, Daniyal Karim, Raphael Kabir Niloy, Shakhinur Islam Mondal   +6 more
wiley   +1 more source

The interplay between Acinetobacter baumannii ZigA and SltB promotes zinc homeostasis and cell envelope integrity

Infection and Immunity
Acinetobacter baumannii is an opportunistic human pathogen that acquires nutrient metals from the vertebrate host amid infection. During zinc (Zn) scarcity, A. baumannii upregulates the expression of the predicted Zn metallochaperone, zigA.
Jeanette M. Critchlow, Juan P. Barraza, Matthew J. Munneke, Evan Krystofiak, Erin R. Green, Eric P. Skaar   +5 more
doaj   +1 more source

Generation of Distinct Differentially Culturable Forms of Burkholderia following Starvation at Low Temperature

Microbiology Spectrum, 2022
Bacteria have developed unique mechanisms to adapt to environmental stresses and challenges of the immune system. Here, we report that Burkholderia pseudomallei, the causative agent of melioidosis, and its laboratory surrogate, Burkholderia thailandensis,
Joss M. Auty, Christopher H. Jenkins, Jennifer Hincks, Anna A. Straatman-Iwanowska, Natalie Allcock, Obolbek Turapov, Edouard E. Galyov, Sarah V. Harding, Galina V. Mukamolova   +8 more
doaj   +1 more source

An atypical orphan carbohydrate-NRPS genomic island encodes a novel lytic transglycosylase. [PDF]

Chem Biol, 2014
Microbial genome sequencing platforms have produced a deluge of orphan biosynthetic pathways suspected of biosynthesizing new small molecules with pharmacological relevance. Genome synteny analysis provides an assessment of genomic island content, which is enriched in natural product gene clusters.
Guo X, Crawford JM.
europepmc   +3 more sources

Molecular aspects and comparative genomics of bacteriophage endolysins [PDF]

, 2013
Phages are recognized as the most abundant and diverse entities on the planet. Their diversity is predominantly determined by their dynamic adaptation capacities, when confronted with different selective pressures in an endless cycle of co-evolution with
Azeredo, Joana, Cerca, Nuno, Ferreira, E. C., Kluskens, Leon, Melo, Luís D. R., Nóbrega, Franklin Luzia, Oliveira, Hugo Alexandre Mendes, Santos, Sílvio Roberto Branco   +7 more
core   +1 more source

Molecular Cloning and Functional Analysis of Holin and Endolysin From Escherichia Phage UE‐M6 as Potential Antibacterial Agents

MicrobiologyOpen, Volume 14, Issue 6, December 2025.
We isolated phage UE‐M6 from wastewater and subsequently cloned, expressed, and purified its encoded endolysin (UE‐lysin) and holin (UE‐holin). Our results demonstrate that the combined application of UE‐lysin and UE‐holin exhibits significantly greater antibacterial activity than either protein alone, indicating a synergistic interaction between the ...
Hira Niaz, Mikael Skurnik, Fazal Adnan
wiley   +1 more source

Phage-derived peptidoglycan degrading enzymes: challenges and future prospects for in vivo therapy [PDF]

, 2018
Peptidoglycan degrading enzymes are of increasing interest as antibacterial agents, especially against multi-drug resistant pathogens. Herein we present a review about the biological features of virion-associated lysins and endolysins, phage-derived ...
Azeredo, Joana, Oliveira, Hugo, São-José, Carlos   +2 more
core   +2 more sources