Novel cortex lytic enzymes in Bacillus megaterium QM B1551 spores. [PDF]
, 2019 Present models for spore germination in Bacillus species include a requirement for either the SleB or CwlJ cortex lytic enzymes to efficiently depolymerise the spore cortex. Previous work has demonstrated that B.
Christie, Graham +3 more
core +1 more source
Multiscale Modelling of Lytic Polysaccharide Monooxygenases [PDF]
arXiv, 2016 Lytic polysaccharide monooxygenase (LPMO) enzymes have attracted considerable attention due to their ability to enhance polysaccharide depolymerization, making them interesting in respect to production of biofuel from cellulose. The LPMOs are metalloenzymes that contain a mononuclear copper active site that can active dioxygen. However, many details of
arxiv
DUF3380 domain from a Salmonella phage endolysin shows potent N -acetylmuramidase activity [PDF]
, 2016 Bacteriophage-encoded endolysins are highly diverse enzymes that cleave the bacterial peptidoglycan layer. Current research focuses on their potential applications in medicine, in food conservation, and as biotechnological tools.
Hans Gerstmans +6 more
core +1 more source
Ivy Proteins as Guardians of Bacterial Cell Wall Integrity: Regulation of Lytic Transglycosylases Explored [PDF]
Lytic transglycosylases (LTs) are bacterial enzymes involved in biosynthesis and maintenance of the peptidoglycan cell wall. LTs are reported to be regulated by two paralogs of Inhibitor of Vertebrate Lysozymes: Ivyp1 and Ivyp2.
Aijaz, Aamna +12 more
core +2 more sources
Recent advances in the structural and molecular biology of type IV secretion systems [PDF]
, 2014 Bacteria use type IV secretion (T4S) systems to deliver DNA and protein substrates to a diverse range of prokaryotic and eukaryotic target cells. T4S systems have great impact on human health, as they are a major source of antibiotic resistance spread ...
Alvarez-Martinez +51 more
core +1 more source
Erythrocyte-Inspired Discoidal Polymeric Nanoconstructs carrying Tissue Plasminogen Activator for the Enhanced Lysis of Blood Clots [PDF]
arXiv, 2019 Tissue plasminogen activator (tPA) is the sole approved therapeutic molecule for the treatment of acute ischemic stroke. Yet, only a small percentage of patients could benefit from this life-saving treatment because of medical contraindications and severe side effects, including brain hemorrhage, associated with delayed administration.
arxiv
Murein-metabolizing enzymes from Escherichia coli: existence of a second lytic transglycosylase [PDF]
, 1992 Henk Engel +3 more
openalex +1 more source
Phage-derived peptidoglycan degrading enzymes: challenges and future prospects for in vivo therapy [PDF]
, 2018 Peptidoglycan degrading enzymes are of increasing interest as antibacterial agents, especially against multi-drug resistant pathogens. Herein we present a review about the biological features of virion-associated lysins and endolysins, phage-derived ...
Azeredo, Joana +2 more
core +2 more sources
High resolution crystal structures of the Escherichia coli lytic transglycosylase slt70 and its complex with a peptidoglycan fragment [PDF]
, 1999 E.J. van Asselt +2 more
openalex +1 more source
PLoS Genetics, 2012 The modulation of fitness by single mutational substitutions during environmental change is the most fundamental consequence of natural selection. The antagonistic tradeoffs of pleiotropic mutations that can be selected under changing environments ...
Moshe Dessau +4 more
doaj +1 more source