Results 101 to 110 of about 497,028 (181)

Real‐Time Neurochemical Sensing in Zebrafish: Electrochemical and Fluorescent Approaches

Analysis &Sensing, Volume 6, Issue 6, November 2026.
The use of zebrafish has emerged as a powerful approach for real‐time neurochemical measurements. This review highlights recent advances in electrochemical and fluorescent sensing strategies that enable dynamic measurements in live preparations of this complex vertebrate. These complementary approaches provide new insights into neurochemical signaling,
Piyanka Hettiarachchi, Jacob T. Theismann, Michael A. Johnson   +2 more
wiley   +1 more source

Phenotypic and Functional Characterization of Müller Glia Isolated from Induced Pluripotent Stem Cell‐Derived Retinal Organoids: Improvement of Retinal Ganglion Cell Function upon Transplantation

Stem Cells Translational Medicine, 2019
Glaucoma is one of the leading causes of blindness, and there is an ongoing need for new therapies. Recent studies indicate that cell transplantation using Müller glia may be beneficial, but there is a need for novel sources of cells to provide ...
Karen Eastlake, Weixin Wang, Hari Jayaram, Celia Murray‐Dunning, Amanda J. F. Carr, Conor M. Ramsden, Anthony Vugler, Katrina Gore, Nadine Clemo, Mark Stewart, Pete Coffey, Peng T. Khaw, G. Astrid Limb   +12 more
doaj   +1 more source

Plagl1 regulates the retinal progenitor cell to Müller glial cell transition.

PLoS Genetics
Müller glia arise from late-stage retinal progenitor cells (RPCs) as a distinct lineage that diverges from neurogenic trajectories. Here, we identify the maternally imprinted gene Plagl1 as a key transcriptional regulator of gliogenesis in the murine ...
Yacine Touahri, Alissa Pak, Luke Ajay David, Joseph Hanna, Hedy Liu, Yucheng Xiao, Lauren Belfiore, Yaroslav Ilnytskyy, Edwin van Oosten, Nobuhiko Tachibana, Lata Adnani, Jiayi Zhao, Mary Hoffman, Rajiv Dixit, Dawn Zinyk, Cynthia J Guidos, Volker Enzmann, Pengpeng Bi, Isabelle Aubert, Laurent Journot, Igor Kovalchuk, Yves Sauvé, Jeff Biernaskie, Chao Wang, Satoshi Okawa, Antonio Del Sol, Carol Schuurmans   +26 more
doaj   +1 more source

Novel NaV1.6‐Mitochondrial Complexes in Retinal Astrocyte Pockets Sequester GABA

Glia, Volume 74, Issue 11, November 2026.
NaV1.6 localizes in retinal astrocytes' high density pockets on the bilayer facing the ganglion cell layer. NaV colocalizes with large, anaplerotic mitochondria. These microdomains accumulate high levels of GABA. ABSTRACT Voltage‐gated sodium channels are best known for their capacity to generate and propagate electrical currents in neurons and muscle.
Joseph Matthew Holden, David John Calkins   +1 more
wiley   +1 more source

Simvastatin Modulates Astrocyte and Microglial Reactivity and Aggressive Behavior After Chronic Sleep Deprivation in Rats

Journal of Neuroscience Research, Volume 104, Issue 11, November 2026.
Simvastatin modulates chronic sleep deprivation‐induced glial remodeling and behavioral responses. ABSTRACT Chronic sleep deprivation (SD) disrupts central nervous system homeostasis, promoting behavioral alterations and glial remodeling within limbic structures.
Higor Hernany Dias, Kevin Silva Müller, Gabriela Larissa Lima‐da‐Silva, Stephane da Silva Alves, Tatiane de Camargo Martins, Pedro Tadao Hamamoto Filho, José de Anchieta de Castro e Horta‐Júnior   +6 more
wiley   +1 more source

Opioid Modulation of Major Neurotransmitter Systems: Acute, Chronic, and Withdrawal Effects

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Opioids are widely used but also frequently misused drugs that affect multiple neurotransmitter systems, including dopaminergic, glutamatergic, GABAergic, serotonergic, and cholinergic pathways. Opioid‐induced neuroadaptations depend on the duration of drug exposure, with distinct changes also emerging following drug discontinuation.
Daniela Novakova, Eliska Pritulova, Jiri Novotny   +2 more
wiley   +1 more source

Müller-Glia-Enriched Genes

, 2013
(A) Müller-glia-enriched genes show stronger expression in retinal progenitors than do genes enriched in other postnatally born cell types. See Materials and Methods for details of how progenitor-enriched and cell-specific expression patterns were ...
Rebecca E Fraioli (3903), Seth Blackshaw (1586), Sanjiv Harpavat (3897), Winston P Kuo (1587), Griffin Weber (3901), Kyungjoon Lee (3902), Constance L Cepko (1593), Seo-Hee Cho (3904), Elizabeth Asch (3906), Wing H Wong (3908), Li Cai (3899), Rachel Yung (3905), Jeff Trimarchi (3898), Haiyan Huang (3900), Lucila Ohno-Machado (3907)   +14 more
core   +1 more source

Differential Cellular Dynamics of Platelet‐Derived Growth Factor Receptor β Cells and Macrophages After Complete Spinal Cord Transection in Neonatal and Juvenile Rats

European Journal of Neuroscience, Volume 64, Issue 9, November 2026.
Following CST, the stumps are connected by fibrous tissue in adult and juvenile rats, whereas they are connected by thin meningeal tissue in neonatal rats. The intensity of PDGFRβ‐positive fibroblasts associated with fibrotic scar formation at the lesion site was significantly higher in juvenile CST rats than in neonatal CST rats.
Masahito Takiguchi, Reina Tamaji, Kengo Funakoshi   +2 more
wiley   +1 more source

Retinal glia regulate development of the circadian photoentrainment circuit

Cell Reports
Summary: Circadian photoentrainment depends on intrinsically photosensitive retinal ganglion cells (ipRGCs), which convey environmental light information to the hypothalamus.
Thomas W. Brown, Noemie Vilallongue, Sarah C. Hales, Shashank Srikanta, Pierre-Luc Rochon, Aline Giselle Rangel Olguin, Sebastián Boy Waxman, Adele Tufford, Jeremie Van Prooijen, Arjun Krishnaswamy, Nicolas Cermakian, Michel Cayouette   +11 more
doaj   +1 more source

Ten‐Eleven Translocation Enzymes Control the Rate and Mode of Retinal Progenitor Cell Division in the Developing Retina

The FASEB Journal, Volume 40, Issue 19, 15 October 2026.
Early RPCs divide predominantly symmetrically and exhibit a high proliferation rate, resulting in rapid retinal growth. Late RPCs divide predominantly asymmetrically and exhibit a low proliferation rate. Our results suggest that TET‐deficient RPCs divide predominantly asymmetrically but exhibit a high proliferation rate.
Galina Dvoriantchikova, Michelle Fleishaker, Byron L. Lam, Dmitry Ivanov   +3 more
wiley   +1 more source