Results 81 to 90 of about 497,028 (181)
British Journal of Pharmacology, EarlyView.The current obesity drug landscape, dominated by GLP‐1 receptor agonists and emerging multi‐agonist therapies, has reinforced that long‐term weight loss is achieved in large part through central mechanisms that suppress appetite and reshape energy balance.
Ines Martinez‐Corral +3 more
wiley +1 more source
, 2023 Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated by Müller glia that reprogram and divide asymmetrically to produce neuronal precursor cells that differentiate into the lost ...
Leah J. Campbell (14596268) +2 more
core +1 more source
Nature Communications, 2017 Müller glia are a type of retinal glial cell important for maintaining retinal structure and implicated in response to retinal damage. Here the authors identify Brevican, a chondroitin sulfate proteoglycan, as a microRNA-modulated regulator of Müller ...
Stefanie G. Wohl +3 more
doaj +1 more source
Kcnv2 E151X Mouse Captures Hallmarks of KCNV2‐Associated Retinal Dystrophy
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background KCNV2‐associated retinopathy is a rare inherited retinal dystrophy caused by variants in the KCNV2 gene, leading to disrupted photoreceptor behaviour and progressive deterioration of vision. Patients have characteristic electroretinography abnormalities, including reduced cone response, delayed and reduced rod response to low light ...
Nermina Xhaferri +3 more
wiley +1 more source
Adult Human Müller Glia Cells Are a Highly Efficient Source of Rod Photoreceptors
, 2011 There is growing evidence that Müller glia cells (MGCs) might act as regenerative elements in injured retinas of fishes and amniotes. However, their differentiation potential in humans is yet unknown.
Grazia Pertile +4 more
core +1 more source
, 2023 Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated by Müller glia that reprogram and divide asymmetrically to produce neuronal precursor cells that differentiate into the lost ...
Leah J. Campbell (14596268) +2 more
core +1 more source
Elucidating the Role of Pten in a Newly defined G0-GALERT Transition in Mammalian Müller glia [PDF]
, 2021 Müller glia are endogenous retinal glia that act as adult stem cells in fish and frogs, replacing dying cells due to injury or disease. However, mammalian Müller glia have lost this ability to self-heal.
David, Luke Ajay
core +1 more source
Evaluation of the Safety and Therapeutic Range of Nanosecond Laser Treatment in Rabbits
Clinical &Experimental Ophthalmology, EarlyView.ABSTRACT Background Subthreshold, nanosecond laser therapy has potential as a treatment for age‐related macular degeneration; however, the therapeutic range and safety profile have not been fully documented. In this study, rabbits were used for a preclinical assessment of nanosecond laser treatment.
Glyn Chidlow +3 more
wiley +1 more source
, 2023 Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated by Müller glia that reprogram and divide asymmetrically to produce neuronal precursor cells that differentiate into the lost ...
Leah J. Campbell (14596268) +2 more
core +1 more source
Rethinking diabetic retinopathy: Homeostatic mechanisms for retinal clearance
Diabetic Medicine, EarlyView.In the healthy retina, balanced production and clearance of metabolic waste and fluid maintain retinal homeostasis and normal visual function. Diabetes disrupts this balance, increasing the accumulation of metabolic waste products, including advanced glycation end products (AGEs) and advanced lipoxidation end products (ALEs), while impairing waste and ...
Karis Little +7 more
wiley +1 more source