Results 61 to 70 of about 497,028 (181)
Uncovering the Hidden Role of GPR37 in Müller Glia-Mediated Neuronal Regeneration
, 2023 G protein-coupled receptor 37 (GPR37) is an orphan receptor that has been shown to maintain the stability of oligodendrocyte myelination. However, despite higher GPR37 expression in the Müller glia, the predominant glia in the retina, than in ...
Liao, Zhixin
core +1 more source
Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine
Medicinal Research Reviews, EarlyView.ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli +5 more
wiley +1 more source
Predicting Mesoscopic Larmor Frequency Shifts in Ex Vivo Porcine Optic Nerve
Magnetic Resonance in Medicine, EarlyView.ABSTRACT Purpose Larmor frequency shifts in white matter (WM) vary with fiber orientation due to anisotropic microstructure. Since clinical voxels are significantly larger than these microscopic frequency variations, the measured signal represents a bulk average of local shifts.
Anders Dyhr Sandgaard +9 more
wiley +1 more source
Developing cell based reporters for the investigation of human pluripotent stem cell derived Müller Glia [PDF]
, 2018 Retinal neuron degenerations of an eye can result in permanent photoreceptor or retinal ganglion cell loss which leads to permanent blindness. One potential approach to restore vision loss is through transplanting stem cell or stem cell-derived retinal ...
Su, Fei
core +1 more source
Frontiers in Cell and Developmental BiologyZebrafish possess the ability to regenerate dying neurons in response to retinal injury, with both Müller glia and microglia playing integral roles in this response.
Celine Lu, David R. Hyde
doaj +1 more source
Stem Cells International, 2017 In humans and other mammals, the neural retina does not spontaneously regenerate, and damage to the retina that kills retinal neurons results in permanent blindness. In contrast to embryonic stem cells, induced pluripotent stem cells, and embryonic/fetal
Krista M. Beach +2 more
doaj +1 more source
Redox Biology, 2020 Glaucoma is a leading cause of blindness worldwide in individuals 60 years of age and older. Despite its high prevalence, the factors contributing to glaucoma progression are currently not well characterized.
Soo-Ho Choi +11 more
doaj +1 more source
Characterization of retinal regeneration in adult zebrafish following multiple rounds of phototoxic lesion [PDF]
PeerJ, 2018 Müller glia in the zebrafish retina respond to retinal damage by re-entering the cell cycle, which generates large numbers of retinal progenitors that ultimately replace the lost neurons.
Alexandra H. Ranski +4 more
doaj +2 more sources
Microglia Ablation and Downstream Effects in the Cerebrospinal Fluid Proteome
PROTEOMICS, EarlyView.ABSTRACT Disease‐related activation of glial cells leads to changes in the cerebrospinal fluid (CSF) proteome. However, assigning such protein changes to their cellular origins is often difficult. Here, we used microglia (and macrophage) depletion in mice to identify CSF proteins of microglial origin.
Sinja Buchner +8 more
wiley +1 more source
Spatial-transcriptomics of postnatal microglia
, 2023 Wiemann S, Potru P, Felix H, Lancelle L, Weiß-Müller J, Spittau B. Spatial-transcriptomics of postnatal microglia. Glia. 2023;71(Suppl.
Lancelle, L. +5 more
core +1 more source