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The Transcriptome of Retinal Müller Glial Cells [PDF]
, 2011 Müller glial cells are the major type of glia in the mammalian retina. To identify the molecular machinery that defines Müller glial cell identity and function, single cell gene expression profiling was performed on Affymetrix microarrays. Identification
Stadler, Michael B +10 more
core +1 more source
Sox2 -Deficient Müller Glia Disrupt the Structural and Functional Maturation of the Mammalian Retina [PDF]
, 2016 Müller glia (MG), the principal glial cells of the vertebrate retina, display quiescent progenitor cell characteristics. They express key progenitor markers, including the high mobility group box transcription factor SOX2 and maintain a progenitor-like ...
Weiss, Ellen R. +2 more
core +1 more source
Müller glia as an important source of cytokines and inflammatory factors present in the gliotic retina during proliferative vitreoretinopathy [PDF]
, 2016 Retinal gliosis is characterized by biochemical and physiological changes that often lead to Müller glia proliferation and hypertrophy and is a feature of many neuro-degenerative and inflammatory diseases such as proliferative vitreoretinopathy (PVR ...
Limb, GA +9 more
core +1 more source
Frontiers in Cell and Developmental Biology, 2019 Unlike mammals, zebrafish have the capacity to regenerate neurons in response to damage. Most zebrafish retinal injury models employ acute damage, which is unlike the chronic, gradual damage that occurs in human retinal diseases.
Maria Iribarne +7 more
doaj +1 more source
Scientific Reports, 2023 Müller glia play very important and diverse roles in retinal homeostasis and disease. Although much is known of the physiological and morphological properties of mammalian Müller glia, there is still the need to further understand the profile of these ...
Karen Eastlake +5 more
doaj +1 more source
Müller glia: stem cells for generation and regeneration of retinal neurons in teleost fish [PDF]
, 2014 Adult zebrafish generate new neurons in the brain and retina throughout life. Growth-related neurogenesis allows a vigorous regenerative response to damage, and fish can regenerate retinal neurons, including photoreceptors, and restore functional vision ...
Raymond, Pamela, Lenkowski, Jenny
core +4 more sources
Organoids as Building Blocks for Adaptive and Resilient Biohybrid Robots
Advanced Materials Technologies, EarlyView.ABSTRACT Biohybrid robots combine engineered living tissues with synthetic materials and have emerged as a promising class of soft robotic systems capable of mimicking biological functions such as biodegradability, energy efficiency and flexible motions. By integrating biological and synthetic components, these systems leverage complementary properties
Antonia Georgopoulou
wiley +1 more source
Advanced Science, EarlyView.Glaucoma, a major cause of blindness, involves retinal ganglion cell (RGC) degeneration. This study shows growth hormone‐releasing hormone receptor (GHRHR) deficiency preserves RGC survival and restores vision, unlike activation which only aids survival.
Yan Tong +24 more
wiley +1 more source
From homeostasis to neurodegeneration: Müller glia in retinal disease
Frontiers in Cell and Developmental BiologyMüller glia are the principal macroglia cells of the retina and are essential for maintaining structural, metabolic, synaptic, and vascular homeostasis.
Matangi Kumar +7 more
doaj +1 more source
Retinal Muller glia initiate innate response to infectious stimuli via toll-like receptor signaling. [PDF]
PLoS ONE, 2012 Ocular surgeries and trauma predispose the eye to develop infectious endophthalmitis, which often leads to vision loss. The mechanisms of initiation of innate defense in this disease are not well understood but are presumed to involve retinal glial cells.
Ashok Kumar, Nazeem Shamsuddin
doaj +1 more source