Results 31 to 40 of about 497,028 (181)
Proliferation potential of Müller glia after retinal damage varies between mouse strains. [PDF]
PLoS ONE, 2014 Retinal Müller glia can serve as a source for regeneration of damaged retinal neurons in fish, birds and mammals. However, the proliferation rate of Müller glia has been reported to be low in the mammalian retina. To overcome this problem, growth factors
Akiko Suga +4 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2023 Zebrafish possess the innate ability to fully regenerate any neurons lost following a retinal injury. This response is mediated by Müller glia that reprogram and divide asymmetrically to produce neuronal precursor cells that differentiate into the lost ...
Patrick Boyd +2 more
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Involvement of HB-EGF/Ascl1/Lin28a Genes in Dedifferentiation of Adult Mammalian Müller Glia
Frontiers in Molecular Biosciences, 2020 Previous studies from this lab have determined that dedifferentiation of Müller glia occurs after eye drop application of an α7 nicotinic acetylcholine receptor (nAChR) agonist, PNU-282987, to the adult rodent eye. PNU-282987 acts on α7 nAChRs on retinal
Megan L. Stanchfield +3 more
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Inflammation Regulates the Multi-Step Process of Retinal Regeneration in Zebrafish
Cells, 2021 The ability to regenerate tissues varies between species and between tissues within a species. Mammals have a limited ability to regenerate tissues, whereas zebrafish possess the ability to regenerate almost all tissues and organs, including fin, heart ...
Mikiko Nagashima, Peter F. Hitchcock
doaj +1 more source
Morphological and physiological interactions of NG2-glia with astrocytes and neurons [PDF]
, 2007 Models of central nervous system (CNS) function have historically been based on neurons and their synaptic contacts - the neuronal doctrine. This doctrine envisages glia as passive supportive cells.
Hamilton, N. +12 more
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, 2022 Clearance phagocytosis is a documented function of Müller glia in the retina. However, the molecular mechanisms of Müller glia phagocytosis remain largely undefined. Here, we show that extracellular galectin-3 and protein S promote clearance phagocytosis
Deborah S. Lew (9129254) +2 more
core +1 more source
Potential of Müller Glia for Retina Neuroprotection [PDF]
, 2020 Müller glia constitute the main glial cells of the retina. They are spatially distributed along this tissue, facilitating their close membrane interactions with all retinal neurons. Müller glia are characterized by their active metabolic functions, which
Limb, GA, Eastlake, K, Luis, J
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Frontiers in Cell and Developmental Biology, 2022 Direct reprogramming of retinal Müller glia is a promising avenue for replacing photoreceptors and retinal ganglion cells lost to retinal dystrophies. However, questions have recently been raised about the accuracy of studies claiming efficient glia-to ...
Nguyet Le +8 more
doaj +1 more source
Attenuation of periostin in retinal Müller glia by TNF-α and IFN-γ [PDF]
International Journal of Ophthalmology, 2019 AIM: To investigate the regulation and mechanisms of periostin expression in retinal Müller glia, and to explore the relevance to retinal neovascularization.
Ying-Qian Peng +10 more
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Development and epigenetic plasticity of murine Müller glia
, 2019 The ability to regenerate the entire retina and restore lost sight after injury is found in some species and relies mostly on the epigenetic plasticity of Müller glia. To understand the role of mammalian Müller glia as a source of progenitors for retinal
Seemungal, Rajeev J +2 more
core +1 more source