Whale Müller glia create a permissive environment supporting retinal ganglion cell survival and neurite outgrowth [PDF]
iScienceSummary: The adult central nervous system has limited regenerative capacity, with retinal ganglion cells (RGCs) particularly refractory to repair. The extracellular glial environment can critically influence neuronal survival and regenerative responses ...
Xandra Pereiro +7 more
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Viral-mediated Pou5f1 (Oct4) overexpression and inhibition of Notch signaling synergistically induce neurogenic competence in mammalian Müller glia [PDF]
eLifeRetinal Müller glia in cold-blooded vertebrates can reprogram into neurogenic progenitors to replace neurons lost to injury, but mammals lack this ability.
Nguyet Le +4 more
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The USH3A causative gene clarin1 functions in Müller glia to maintain retinal photoreceptors. [PDF]
PLoS GeneticsMutations in CLRN1 cause Usher syndrome type IIIA (USH3A), an autosomal recessive disorder characterized by hearing and vision loss, and often accompanied by vestibular dysfunction.
Hannah J T Nonarath +6 more
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Effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health [PDF]
, 2021 The importance of Müller glia for retinal homeostasis suggests that they may have vulnerabilities that lead to retinal disease. Here, we studied the effect of selectively knocking down key metabolic genes in Müller glia on photoreceptor health ...
Du, Jianhai +29 more
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Retinal regeneration requires dynamic Notch signaling
Neural Regeneration Research, 2022 Retinal damage in the adult zebrafish induces Müller glia reprogramming to produce neuronal progenitor cells that proliferate and differentiate into retinal neurons. Notch signaling, which is a fundamental mechanism known to drive cell-cell communication,
Leah J Campbell +3 more
doaj +1 more source
Müller glia activation in response to inherited retinal degeneration is highly varied and disease-specific [PDF]
, 2015 Despite different aetiologies, most inherited retinal disorders culminate in photoreceptor loss, which induces concomitant changes in the neural retina, one of the most striking being reactive gliosis by Müller cells.
Graca, AB +34 more
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Glutathione-Induced Calcium Shifts in Chick Retinal Glial Cells. [PDF]
PLoS ONE, 2016 Neuroglia interactions are essential for the nervous system and in the retina Müller cells interact with most of the neurons in a symbiotic manner. Glutathione (GSH) is a low-molecular weight compound that undertakes major antioxidant roles in neurons ...
Hercules R Freitas +12 more
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Epigenetic mechanisms of Müller glial reprogramming mediating retinal regeneration
Frontiers in Cell and Developmental Biology, 2023 Retinal degenerative diseases, characterized by retinal neuronal death and severe vision loss, affect millions of people worldwide. One of the most promising treatment methods for retinal degenerative diseases is to reprogram non-neuronal cells into stem
Tian-En Si +9 more
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Effects of glutamate receptor activation on NG2-glia in the rat optic nerve [PDF]
, 2009 NG2-glia are a substantial population of cells in the central nervous system (CNS) that can be identified by their specific expression of the NG2 chondroitin sulphate (CSPG).
Hubbard, Paul S. +8 more
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Data_Sheet_1_Yap Regulates Müller Glia Reprogramming in Damaged Zebrafish Retinas.zip
, 2021 Vertebrates such as zebrafish have the outstanding ability to fully regenerate their retina upon injury, while mammals, including humans, do not. In zebrafish, upon light-induced injury, photoreceptor regeneration is achieved through reprogramming of ...
Jorge Borbinha (11453812) +4 more
core +1 more source