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Insights on the Regeneration Potential of Müller Glia in the Mammalian Retina [PDF]
Cells, 2021 Müller glia, the major glial cell types in the retina, maintain retinal homeostasis and provide structural support to retinal photoreceptors. They also possess regenerative potential that might be used for retinal repair in response to injury or disease.
Ahmed Salman +2 more
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Scientific Reports, 2023 Retinal Müller glia have a capacity to regenerate neurons in lower vertebrates like zebrafish, but such ability is extremely limited in mammals. In zebrafish, Müller glia proliferate after injury, which promotes their neurogenic reprogramming while ...
Reiko Nishino +3 more
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Heterogeneity in quiescent Müller glia in the uninjured zebrafish retina drive differential responses following photoreceptor ablation [PDF]
Frontiers in Molecular Neuroscience, 2023 IntroductionLoss of neurons in the neural retina is a leading cause of vision loss. While humans do not possess the capacity for retinal regeneration, zebrafish can achieve this through activation of resident Müller glia. Remarkably, despite the presence
Aaron Krylov +7 more
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Organoid-derived human retinal progenitor cells promote early dedifferentiation of Müller glia in Royal College of Surgeons rats [PDF]
International Journal of Ophthalmology, 2023 AIM: To explore whether the subretinal transplantation of retinal progenitor cells from human embryonic stem cell-derived retinal organoid (hERO-RPCs) could promote Müller glia dedifferentiation and transdifferentiation, thus improving visual function ...
Qiang Guo +4 more
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Regulations of Retinal Inflammation: Focusing on Müller Glia
Frontiers in Cell and Developmental Biology, 2022 Retinal inflammation underlies multiple prevalent retinal diseases. While microglia are one of the most studied cell types regarding retinal inflammation, growing evidence shows that Müller glia play critical roles in the regulation of retinal ...
Yingying Chen +9 more
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eLife, 2023 In the lesioned zebrafish retina, Müller glia produce multipotent retinal progenitors that generate all retinal neurons, replacing lost cell types. To study the molecular mechanisms linking Müller glia reactivity to progenitor production and neuronal ...
Laura Celotto +7 more
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Frontiers in Cellular Neuroscience, 2022 Clearance phagocytosis is a documented function of Müller glia in the retina. However, the molecular mechanisms of Müller glia phagocytosis remain largely undefined. Here, we show that extracellular galectin-3 and protein S promote clearance phagocytosis
Deborah S. Lew +2 more
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Genome-wide analysis of Müller glial differentiation reveals a requirement for Notch signaling in postmitotic cells to maintain the glial fate. [PDF]
PLoS ONE, 2011 Previous studies have shown that Müller glia are closely related to retinal progenitors; these two cell types express many of the same genes and after damage to the retina, Müller glia can serve as a source for new neurons, particularly in non-mammalian ...
Branden R Nelson +7 more
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Müller Glia in Retinal Development: From Specification to Circuit Integration
Frontiers in Neural Circuits, 2022 Müller glia of the retina share many features with astroglia located throughout the brain including maintenance of homeostasis, modulation of neurotransmitter spillover, and robust response to injury.
Joshua M. Tworig +2 more
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Scientific Reports, 2022 Mammalian Müller glia express transcription factors and cell cycle regulators essential for the function of retinal progenitors, indicating the latent neurogenic capacity; however, the role of these regulators remains unclear.
Maki Kato +4 more
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