Results 41 to 50 of about 29,457,324 (296)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Designing an Effective Learning Environment for Language Learning During the Covid-19 Pandemic

Frontiers in Psychology, 2021
The rapid development in IT in the twenty-first century have along with the COVID-19 pandemic have had effects on the field of education, with the need to use technology for educational purposes arising.
Olkan Betoncu, Funda G. Faslı, Funda G. Faslı, Fezile Ozdamli, Fezile Ozdamli   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

M-Learning: Focus on Digital Fluency

International Journal of Advanced Corporate Learning (iJAC), 2020
<span style="vertical-align: inherit;"><span style="vertical-align: inherit;">O presente artigo trata da criação de uma arquitetura pedagógica (PA) para auxiliar professores e alunos no desenvolvimento da fluência digital por meio da aprendizagem móvel.
Patrícia Alejandra Behar, Tássia Priscila Fagundes Grande, Anna Helena Silveira Sonego, Sibele Pedroso Loss   +3 more
openaire   +3 more sources

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Intelligent‑TPACK in practice: design and evidence from a three‑week teacher preparation module

Computers and Education Open
Rapid advances in generative AI sharpen the need for teachers to develop pedagogical and ethical capacities for AI‑integrated instruction. While Technological Pedagogical Content Knowledge (TPACK) provides a valuable framework for technology integration,
Tugce Aldemir, Selcuk Kilinc, Ali Bicer, Patricia Grant, Trina Davis, Noelle Wall Sweany   +5 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Toward mobile learning deployment in higher education [PDF]

, 2014
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Mobile Learning (M-learning) refers to any kind of learning which takes place within and beyond the traditional learning environment via wireless mobile ...
Abu-Al-Aish, Ahmad
core   +4 more sources

Elementary teachers' knowledge, self-efficacy, and philosophy of teaching spelling in the United States: attention to linguistic diversity

Frontiers in Education
IntroductionSpelling is a complex literacy skill that supports students' success in reading and writing. This study examined elementary teachers' general spelling knowledge, African American English and Spanish-related spelling knowledge, self-efficacy ...
Ramona T. Pittman, Heesun Chang, Kimberly Wright   +2 more
doaj   +1 more source