Results 121 to 130 of about 19,797,232 (311)
Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
The Elementary Divisors, Associated with 0, of a Singular M-matrix [PDF]
Proceedings of the Edinburgh Mathematical Society, 1956 1. Many investigations have been concerned with a squaro matrix P with non-negative coefficients (elements). It is remarkable that many interesting properties of P are determined by the set Σ of index pairs of positive (i.e. non-zero) coefficients of P, the actual values of these coefficients being irrelevant.
openaire +2 more sources
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Using underapproximations for sparse nonnegative matrix factorization [PDF]
Nonnegative Matrix Factorization (NMF) has gathered a lot of attention in the last decade and has been successfully applied in numerous applications.
GILLIS, Nicolas, GLINEUR, François
core
Data matrix: Acropyga_UCE-944-matrix
, 2016 Data matrix: Acropyga_UCE-944 ...
John S. LaPolla (134265) +4 more
core +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
The information matrix test with bootstrap-based covariance matrix estimation. [PDF]
We propose an information matrix test in which the covariance matrix of the vector of indicators is estimated using the parametric bootstrap. Monte Carlo results and heuristic arguments show that its small sample performance is comparable with that of ...
Hoorelbeke, Dirk, Dhaene, Geert
core +2 more sources
The normalized matrix perturbation method [PDF]
, 2020 In 1926, Schrodinger supplied the theoretical basis for analyzing the time evolution of a quantum system through his famous equation that now bears his name. Soon after its advent, an intrinsic interest emerged to get exactly solvable models by using the
Braulio M. Villegas Martínez
core
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source