Results 11 to 20 of about 27,333,880 (308)

Immune evasion and provocation by Mycobacterium tuberculosis

Nature Reviews Microbiology, 2022
Mycobacterium tuberculosis, the causative agent of tuberculosis, has infected humans for millennia. M. tuberculosis is well adapted to establish infection, persist in the face of the host immune response and be transmitted to uninfected individuals.
P. Chandra, Steven J. Grigsby, J. Philips   +2 more
semanticscholar   +3 more sources

Assessment of the Prevalence and Epidemic Spread of Strains of Ancient, and Modern Sublineages of the Mycobacterium tuberculosis Beijing Genotype in Omsk Region

Эпидемиология и вакцинопрофилактика, 2020
Relevance. The spread of the epidemic and resistant Mycobacterium tuberculosis genotypes presents a serious threat to the implementation of the national tuberculosis control program in Russia.
O. A. Pasechnik, A. A. Vyazovaya, A. I. Bloch, I. V. Yarusova, M. P. Tatarintseva, I. V. Mokrousov   +5 more
doaj   +1 more source

Mechanisms of M. tuberculosis Immune Evasion as Challenges to TB Vaccine Design.

Cell Host and Microbe, 2018
Tuberculosis (TB) is a large global health problem, in part because of the long period of coevolution of the pathogen, Mycobacterium tuberculosis, and its human host.
J. Ernst
semanticscholar   +1 more source

Development of a Novel Lead that Targets M. tuberculosis Polyketide Synthase 13

Cell, 2017
Summary Widespread resistance to first-line TB drugs is a major problem that will likely only be resolved through the development of new drugs with novel mechanisms of action.
Anup Aggarwal, M. Parai, N. Shetty, D. Wallis, Lisa K. Woolhiser, Courtney Hastings, N. Dutta, S. Galaviz, Ramesh C. Dhakal, R. Shrestha, Shoko Wakabayashi, C. Walpole, D. Matthews, D. Floyd, P. Scullion, Jennifer Riley, O. Epemolu, S. Norval, Thomas C. Snavely, G. Robertson, E. Rubin, T. Ioerger, Frik A. Sirgel, R. G. van der Merwe, P. V. van Helden, P. Keller, E. Böttger, P. Karakousis, A. Lenaerts, J. Sacchettini   +29 more
semanticscholar   +1 more source

INVESTIGATION OF RANGES AND FREQUENCY OF MUTATIONS IN THE embB GENE IN MYCOBACTERIUMTUBERCULOSIS ASSOCIATED WITH RESISTANCE TO ETHAMBUTOL USING REAL-TIME POLYMERASE CHAINREACTION

Туберкулез и болезни лёгких, 2017
Based on real-time allele-specific polymerase chain reaction, the ranges of potential mutations in codons of 306 and 405 of the embBgene in Mycobacterium tuberculosis associated with resistance to ethambutol were investigated.
Yu. S. Аlyapkinа, E. E. Lаrionovа, T. G. Smirnovа, Ya. I. Аlekseev, L. N. Chernousovа, M. A. Vlаdimirskiy   +5 more
doaj   +1 more source

The impact of the infection caused by hepatitis B and C on the characteristics of hepatotoxic reactions in tuberculosis patients

Туберкулез и болезни лёгких, 2020
The objective of the study: to identify the specific parameters of hepatotoxic reactions in tuberculosis patients depending on the presence of hepatitis B and C markers in the blood. Subjects and methods. The state of the hepatobiliary system was studied
V. V. Dantsev, R. D. Muchaidze, L. R. Levina, M. G. Spitsyn, V. S. Tokmakov, G. S. Balasanyants   +5 more
doaj   +1 more source

Comparative characteristics of tuberculous pleurisy depending on HIV status

Туберкулез и болезни лёгких, 2016
Goal of the study: to study specific manifestations of tuberculous pleurisy in HIV patients, to evaluate the efficiency of video-assisted thoracoscopy when diagnosing tuberculous pleurisy in case of different HIV status of the patients.Materials and ...
E. V. Korzh, D. S. Miroshnichenko
doaj   +1 more source

The population structure of Beijing family of Mycobacterium tuberculosis in Western Siberia

Туберкулез и болезни лёгких, 2020
The objective: to study the structure of Beijing genotype family of Mycobacterium tuberculosis in Omsk Region, Western Siberia.Subjects and methods: 325 strains of M. tuberculosis were studied, all of them were isolated from tuberculosis patients in Omsk
A. A. Vyazovaya, O. A. Pasechnik, A. A. Gerasimova, I. V. Mokrousov   +3 more
doaj   +1 more source

Tuberculous meningitis in patients with concurrent tuberculosis and HIV infection who have started antiretroviral therapy: the specific course and prognosis

Туберкулез и болезни лёгких, 2019
The objective: to study the course of tuberculous meningitis (TM) in patients with HIV infection after the initiation of antiretroviral therapy (ART) and evaluate their effect on the outcome prognosis.Subjects and methods.
E V. Korzh, N. A. Podchos
doaj   +1 more source

EXPERIMENTAL COMPARISON OF THE AEROSOL METHOD OF DISINFECTION OF AIR AND SURFACES CONTAMINATED BY M. TUBERCULOSIS

Туберкулез и болезни лёгких, 2018
The objective of the study: to analyze efficiency of an aerosol method of M. tuberculosis deactivation in the air and on surfaces versus the conventional methods of the disinfectants' application.Subjects and Methods. The article describes the evaluation
V. V. Kuzin, E. B. Shmаtkovа, N. S. Grischenko, T. I. Rudnitskаya, M. V. Fursov, V. D. Potаpov   +5 more
doaj   +1 more source