Endothelial Cell Organization Drives Distinct Agonist‐Specific Ca2+ Dynamics in Arteries and Veins
Acta Physiologica, Volume 241, Issue 12, December 2025.ABSTRACT Aim The endothelium regulates cardiovascular function by detecting and interpreting multiple extracellular signals from blood and surrounding tissues, even when these inputs are complex and conflicting. The major challenge faced by the endothelium is decoding this dynamic chemical environment to produce coordinated endothelial cellular ...
M. D. Lee +6 more
wiley +1 more source
The Concise Guide to PHARMACOLOGY 2025/26: G protein‐coupled receptors
British Journal of Pharmacology, Volume 182, Issue S1, Page S24-S151, December 2025.The Concise Guide to Pharmacology 2025/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear,
Stephen P. H. Alexander +206 more
wiley +1 more source
Ligand-guided homology modeling drives identification of novel histamine H3 receptor ligands [PDF]
, 2019 In this study, we report a ligand-guided homology modeling approach allowing the analysis of relevant binding site residue conformations and the identification of two novel histamine H3 receptor ligands with binding affinity in the nanomolar range.
Hagenow, Stefanie +3 more
core +2 more sources
Anti-M3 muscarinic acetylcholine receptor antibodies in systemic lupus erythematosus
, 2015 Fil: Pisoni, Cecilia.
Reina, Silvia Lorena +5 more
openaire +2 more sources
Role of M3 Muscarinic Acethylcholine Receptor Antibodies as a New Marker in Primary Sjögren Syndrome [PDF]
, 2017 Aims: This paper investigates the presence of M3 muscarinic acetylcholine receptor autoantibody present in the serum of patients with primary Sjögren syndrome (pSS).
Borda, Enri Santiago +4 more
core +1 more source
Muscarinic cannabinoid suppression of excitation, a novel form of coincidence detection
Pharmacological ResearchΔ9-tetrahydrocannabinol (THC), the chief psychoactive ingredient of cannabis, acts in the brain primarily via cannabinoid CB1 receptors. These receptors are implicated in several forms of synaptic plasticity – depolarization-induced suppression of ...
Michaela Dvorakova +2 more
doaj +1 more source
Atropine can induce autophagy independent of the M3 muscarinic acetylcholine receptor
, 2022 Abstract Atropine is a well-known muscarinic acetylcholine receptor (mAchR) antagonist; it has been used widely in medicine in that role. Autophagy plays an important role in many physiological processes. In this study, human renal epithelium (293T) cells were treated with different physiological regulators.
Xin Liu +4 more
openaire +1 more source
Cancer Cell International, 2018 Background Cholangiocarcinoma is a highly malignant tumor type that is not sensitive to radiotherapy or chemotherapy due to aggressive perineural invasion and metastasis.
Yujie Feng +9 more
doaj +1 more source
Assessment of the molecular mechanisms of action of novel 4-phenylpyridine-2-one and 6-phenylpyrimidin-4-one allosteric modulators at the M1 muscarinic acetylcholine receptors [PDF]
, 2018 Positive allosteric modulators (PAMs) that target the M1 muscarinic acetylcholine (ACh) receptor (M1 mAChR) are potential treatments for cognitive deficits in conditions such as Alzheimer's disease and schizophrenia.
Andrew B. Tobin +15 more
core +2 more sources
The Journal of Maternal-Fetal & Neonatal MedicineObjectives Gestational diabetes mellitus (GDM) is a prevalent metabolic disorder affecting pregnancy, leading to significant maternal and fetal complications.
Süleyman Cemil Oğlak +5 more
doaj +1 more source