Results 11 to 20 of about 13,431 (216)

Histamine H1 Receptor Down-Regulation Mediated by M3 Muscarinic Acetylcholine Receptor Subtype

Journal of Pharmacological Sciences, 2004
Heterologous down-regulation of histamine H1 receptor (H1R) mediated by muscarinic acetylcholine receptor subtype was investigated using five kinds of Chinese hamster ovary (CHO) cells stably co-expressing the human H1R and one of the five (M1 –M5 ...
Katsuhiro Miyoshi, Nozomi Kawakami, Yousuke Wakayama, Norimasa Izumi, Shuhei Horio, Hiroyuki Fukui   +5 more
doaj   +4 more sources

Molecular mechanism of muscarinic acetylcholine receptor M3 interaction with Gq

Communications Biology
Muscarinic acetylcholine receptor M3 (M3) and its downstream effector Gq/11 are critical drug development targets due to their involvement in physiopathological processes.
Donghee Ham, Asuka Inoue, Jun Xu, Yang Du, Ka Young Chung   +4 more
doaj   +3 more sources

The M3 Muscarinic Acetylcholine Receptor Promotes Epidermal Differentiation. [PDF]

J Invest Dermatol, 2022
The M3 muscarinic acetylcholine receptor is predominantly expressed in the basal epidermal layer where it mediates the effects of the autocrine/paracrine cytotransmitter acetylcholine. Patients with the autoimmune blistering disease pemphigus develop autoantibodies to M3 muscarinic acetylcholine receptor and show alterations in keratinocyte adhesion ...
Duan J, Grando C, Liu S, Chernyavsky A, Chen JK, Andersen B, Grando SA.   +6 more
europepmc   +5 more sources

M3 muscarinic acetylcholine receptor-reactive Th17 cells in primary Sjögren's syndrome. [PDF]

JCI Insight, 2020
M3 muscarinic acetylcholine receptor (M3R) is one of the autoantigens associated with Sjögren's syndrome (SS) and is localized in exocrine glands where disease-specific inflammation occurs. The inflammatory lesion is characterized by infiltration of CD4+ T cells, including clonally expanded Th17 cells.
Abe S, Tsuboi H, Kudo H, Asashima H, Ono Y, Honda F, Takahashi H, Yagishita M, Hagiwara S, Kondo Y, Matsumoto I, Sumida T.   +11 more
europepmc   +4 more sources

Structure-guided development of selective M3 muscarinic acetylcholine receptor antagonists. [PDF]

Proc Natl Acad Sci U S A, 2018
Significance The development of selective antagonists for muscarinic acetylcholine receptors is challenging due to high homology in orthosteric binding sites among subtypes. Starting from a single amino acid difference in the orthosteric pockets in M2 muscarinic acetylcholine receptor (M2R) and M3R, we developed an M3R-selective antagonist ...
Liu H, Hofmann J, Fish I, Schaake B, Eitel K, Bartuschat A, Kaindl J, Rampp H, Banerjee A, Hübner H, Clark MJ, Vincent SG, Fisher JT, Heinrich MR, Hirata K, Liu X, Sunahara RK, Shoichet BK, Kobilka BK, Gmeiner P.   +19 more
europepmc   +6 more sources

Signal transduction by M3 muscarinic acetylcholine receptor in prostate cancer. [PDF]

Oncol Lett, 2016
The present study aimed to investigate the potential mechanisms used during signal transduction by M3 muscarinic acetylcholine receptor (CHRM3) in prostate cancer. The microarray datasets of GSE3325, including 5 clinically localized primary prostate cancers and 4 benign prostate tissues, were downloaded from the Gene Expression Omnibus database.
Guo L, Liu Y, Ding Z, Sun W, Yuan M.
europepmc   +4 more sources

Novel insights into M3 muscarinic acetylcholine receptor physiology and structure. [PDF]

J Mol Neurosci, 2014
Recent studies with M3 muscarinic acetylcholine receptor (M3R) mutant mice suggest that drugs selectively targeting this receptor subtype may prove useful for the treatment of various pathophysiological conditions. Moreover, the use of M3R-based designer G protein-coupled receptors (GPCRs) has provided novel insights into how Gq-coupled GPCRs can ...
Kruse AC, Li J, Hu J, Kobilka BK, Wess J.   +4 more
europepmc   +4 more sources

Structure and dynamics of the M3 muscarinic acetylcholine receptor. [PDF]

Nature, 2012
Acetylcholine, the first neurotransmitter to be identified, exerts many of its physiological actions via activation of a family of G-protein-coupled receptors (GPCRs) known as muscarinic acetylcholine receptors (mAChRs). Although the five mAChR subtypes (M1-M5) share a high degree of sequence homology, they show pronounced differences in G-protein ...
Kruse AC, Hu J, Pan AC, Arlow DH, Rosenbaum DM, Rosemond E, Green HF, Liu T, Chae PS, Dror RO, Shaw DE, Weis WI, Wess J, Kobilka BK.   +13 more
europepmc   +4 more sources

Expression of M3 muscarinic acetylcholine receptors in gastric cancer

Romanian Journal of Morphology and Embryology, 2022
Gastric cancer represents a real public health problem as far as incidence, aggressiveness and unfavorable prognosis are concerned. The autonomous nervous system might be one of the major factors involved in the onset, progression, and metastasis, both sympathetically and parasympathetically.
Mehedinţeanu, Alina Maria, Mirea, Cecil Sorin, Stovicek, Puiu Olivian, Schenker, Michael, Stancu, Marius Ionuţ, Ciurea, Ana-Maria, Streba, Liliana, Istrate-Ofiţeru, Anca-Maria, Sas, Teodor-Nicuşor, Vere, Cristin Constantin   +9 more
openaire   +2 more sources

Effect of M3 muscarinic acetylcholine receptor deficiency on collagen antibody-induced arthritis. [PDF]

Arthritis Res Ther, 2016
Background: There is increasing evidence that the non-neuronal cholinergic system might be of importance for the pathology of rheumatoid arthritis. The role of M3 muscarinic acetylcholine receptor (M3R) in this regard has, however, not been investigated to date.
Beckmann J, Dittmann N, Schütz I, Klein J, Lips KS.   +4 more
europepmc   +8 more sources