Results 11 to 20 of about 2,347 (191)

Clinical significance of serum M30 and M65 levels in metastatic pancreatic adenocarcinoma

Tumor Biology, 2013
M30 and M65 are relatively new assays that detect different circulating forms of the epithelial cell structural protein cytokeratin 18. This study was conducted to investigate the serum levels of M30 and M65 in patients with metastatic pancreatic adenocarcinoma (MPA) and the relationship with tumor progression and known prognostic parameters.
Faruk Tas, Senem Karabulut, Elif Bilgin   +2 more
exaly   +4 more sources

Evaluation of serum M30 and M65 activity in patients with stage-I endometrial cancer

Journal of Obstetrics and Gynaecology, 2019
We aimed to analyse the prognostic value of serum oxidative stress parameters and apoptotic markers of serum M30/65 levels in endometrial cancer patients. Serum M30/65 levels and oxidative stress parameters were evaluated in 52 women with stage I endometrial cancer (n = 26) and a control group of healthy females (n = 26).
Aysun Camuzcuoglu, Burak Sezgin, Hakim Çelik   +2 more
exaly   +5 more sources

Clinical Evaluation of M30 and M65 ELISA Cell Death Assays as Circulating Biomarkers in a Drug-Sensitive Tumor, Testicular Cancer [PDF]

Neoplasia: An International Journal for Oncology Research, 2008
Circulating full-length and caspase-cleaved cytokeratin 18 (CK18) are considered biomarkers of chemotherapy-induced cell death measured using a combination of the M30 and M65 ELISAs.
Esther C. de Haas, Alessandra di Pietro, Kathryn L. Simpson, Coby Meijer, Albert J.H. Suurmeijer, Lee J. Lancashire, J. Cummings, Steven de Jong, Elisabeth G.E. de Vries, Caroline Dive, Jourik A. Gietema   +10 more
doaj   +2 more sources

Accuracy of cytokeratin 18 (M30 and M65) in detecting non-alcoholic steatohepatitis and fibrosis: A systematic review and meta-analysis

PLoS ONE, 2020
Introduction Association between elevated cytokeratin 18 (CK-18) levels and hepatocyte death has made circulating CK-18 a candidate biomarker to differentiate non-alcoholic fatty liver from non-alcoholic steatohepatitis (NASH).
Jenny Lee, Yasaman Vali, Jérôme Boursier, Kevin Duffin, Joanne Verheij, M. Julia Brosnan, Koos Zwinderman, Quentin M. Anstee, Patrick M. Bossuyt, Mohammad Hadi Zafarmand, Pavel Strnad   +10 more
doaj   +3 more sources

Onset of heart failure determines the hepatic cell death pattern

Annals of Hepatology, 2011
Background and rationale. Acute and chronic heart failure (HF) may affect the liver, but the underlying mechanisms that lead to progressive liver damage are poorly understood.
Kerstin Herzer, Guntje Kneiseler, Lars Peter Bechmann, Felix Post, Martin Schlattjan, Jan-Peter Sowa, Till Neumann, Günter Marggraf, Raimund Erbel, Guido Gerken, Ali Canbay, Christoph Jochum   +11 more
doaj   +2 more sources

Association of Circulating Markers of Microbial Translocation and Hepatic Inflammation with Liver Injury in Patients with Type 2 Diabetes [PDF]

Biomedicines
Background: Virtually the entire spectrum of liver disease is observed in association with type 2 diabetes mellitus (T2DM); indeed, T2DM is now the most common cause of liver disease in the U.S.
Leila Gobejishvili, Vatsalya Vatsalya, Diana V. Avila, Yana B. Feygin, Craig J. McClain, Sriprakash Mokshagundam, Shirish Barve   +6 more
doaj   +2 more sources

OPTICAL AND ULTRAVIOLET OBSERVATIONS OF A LOW-VELOCITY TYPE II PLATEAU SUPERNOVA 2013am IN M65 [PDF]

The Astrophysical Journal, 2014
14 pages, 11 figures, 6 tables, Accepted for publication in ...
Jujia Zhang, Xiaofeng Wang, Paolo A. Mazzali, Jinming Bai, Tianmeng Zhang, David Bersier, Fang Huang, Yufeng Fan, Jun Mo, Jianguo Wang, Weimin Yi, Chuanjun Wang, Yuxin Xin, null Liangchang, Xiliang Zhang, Baoli Lun, Xueli Wang, Shousheng He, Emma S. Walker   +18 more
openaire   +4 more sources

From the Liver to Heart in Nonalcoholic Fatty Liver Disease: Single-Cell and Serum Evidence for Cytokeratin 18 in Predicting Cardiovascular Risk. [PDF]

Cardiovasc Ther
Background This study is aimed at measuring the expression of serum cytokeratin 18 (CK18) in patients with nonalcoholic fatty liver disease (NAFLD) and at evaluating its ability to discriminate NAFLD patients with and without coronary heart disease (CHD), thereby elucidating its potential role in reflecting the link between NAFLD and increased ...
Xu H, Ma X, Chen F, Zhou B.
europepmc   +2 more sources

Multicore SPION Clustering within Poly(amino acid) Corrals for Enhanced MRI Contrast and Drug Release. [PDF]

Small
Clusters of small hydrophobic SPIONs stabilized by amphiphilic poly(amino acid) block copolymers with varying degrees of lipophilicity. Magnetic field inhomogeneities arising from dipolar interactions yield high and selective transverse relaxivity for negative contrast MRI and provide for stimulated drug release with initial drug loading determined by ...
Kabil MF, Akinmola AT, Pan A, Anik MI, Mills R, Scholz C, Walsh EG, Bothun GD.   +7 more
europepmc   +2 more sources

Exploration of Multiple Non-Invasive Tests for Assessing Response to Treatment in a Semaglutide Phase 2b Trial in Patients with MASH. [PDF]

Aliment Pharmacol Ther
This study investigated multiple non‐invasive tests (NIT) in a phase 2b study of patients with MASH and fibrosis treated with semaglutide. Findings revealed that semaglutide significantly improved NIT scores versus placebo from as early as 28 weeks. The results support the use of NITs to assess a treatment response to semaglutide.
Nitze LM, Ratziu V, Sanyal AJ, Wong VW, Balendran C, Fleckner J, Skalshøi Kjær M, Krarup N, Anstee QM.   +8 more
europepmc   +2 more sources