Honokiol Inhibits Melanoma Growth by Targeting Keratin 18 in vitro and in vivo [PDF]
Frontiers in Cell and Developmental Biology, 2020 Honokiol, a natural compound, derived from Magnolia officinalis, has been shown to have anti-cancer effect in several cancer types. However, the underlying molecular mechanism associated with its anti-cancer properties has not been fully elucidated.
Tingting Liu +19 more
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Total Keratin-18 (M65) as a Potential, Early, Non-Invasive Biomarker of Hepatocyte Injury in Alcohol Intoxicated Adolescents—A Preliminary Study [PDF]
Biomolecules, 2021 Background: Underage drinking is associated with health risk behaviors. Serum keratin-18 (CK18) levels are increased in liver diseases and may be biomarkers of outcome. The purpose of this study was to determine if the total CK18 (M65) or caspase-cleaved
Katarzyna Zdanowicz +5 more
doaj +2 more sources
Keratin-18: Diagnostic, Prognostic, and Theragnostic for Alcohol-Associated Hepatitis. [PDF]
Am J Gastroenterol, 2021 Abstract It is still sometimes difficult to differentiate alcohol-associated hepatitis (AH) from other liver problems. In this edition of AJG, Atkinson et al. showed that keratin-18 (intermediate filament protein) is a promising biomarker for predicting histological severity of AH, defining the type of hepatocyte death (necrosis vs apoptosis),
McClain CJ, Vatsalya V, Mitchell MC.
europepmc +4 more sources
Keratin 18 Is a Diagnostic and Prognostic Factor for Acute Alcoholic Hepatitis. [PDF]
Clin Gastroenterol Hepatol, 2020 Acute alcoholic hepatitis (AAH) is a major cause of liver-related morbidity and mortality; there are no good blood biomarkers for diagnosis or determining magnitude of cell death. Keratin 18 (KRT18, also called K18), found in epithelial cells, is released from hepatocytes upon death. We investigated whether level of K18 is a better marker of hepatocyte
Vatsalya V +12 more
europepmc +5 more sources
Time-Course Changes of Serum Keratin Concentrations after Liver Transplantation: Contrasting Results of Keratin-18 and Keratin-19 Fragments [PDF]
Case Reports in Hepatology, 2020 Objective. Under normal conditions, adult hepatocytes express only keratin-8 (K8) and keratin-18 (K18), whereas cholangiocytes also express K19. In this study, we delineate the pattern of normal time-course changes in serum K19 and K18 levels after liver
Cristina Macía +7 more
doaj +2 more sources
Systemic inflammation is associated with circulating cell death released keratin 18 fragments in colorectal cancer [PDF]
OncoImmunology, 2020 Systemic inflammation is a stage-independent marker of poor prognosis in colorectal cancer (CRC), activated in a complex, multifactorial process. It has been proposed that one of the main factors driving systemic inflammation may be tumor necrosis ...
Päivi Sirniö +9 more
doaj +2 more sources
Keratin 18 phosphorylation as a progression marker of chronic hepatitis B [PDF]
Virology Journal, 2010 Background The intermediate filament proteins keratins 18 (K18) and 8 (K8) polymerize to form the cytoskeletal network in the mature hepatocytes. It has been shown that the phosphorylation of K18 at two serine residues, 33 and 52, correlates with the ...
Wu Hao +8 more
doaj +3 more sources
Serum keratin‐18 detects hepatic inflammation and predicts progression in compensated alcohol‐associated liver disease [PDF]
Hepatology Communications, 2022 Alcohol‐associated liver fibrosis accumulates over decades, driven by hepatic inflammation and cell death. We investigated the diagnostic accuracy of keratin‐18 degradation, measured using serum M30 and M65 levels, and the ActiTest for hepatic ...
Katrine Holtz Thorhauge +9 more
doaj +2 more sources
Is Keratin-18 only a Marker of Cell Death in Acute-On-Chronic Liver Failure? [PDF]
J Lab Precis Med, 2018 Acute liver failure (ALF) due to a variety of causes has been well established clinically for a number of decades (1). An intense research focus has recently been generated in the realm of acute-on-chronic liver failure (ACLF), especially in light of the high number of cirrhotic patients that eventually present to the clinic (2).
Woolbright BL, Jaeschke H.
europepmc +4 more sources
Oblongifolin C inhibits metastasis by up-regulating keratin 18 and tubulins. [PDF]
Sci Rep, 2015 AbstractTumor metastasis is the main cause of cancer-related patient death. In this study, we performed a wound healing migration screen to search for a metastatic inhibitor within our library of natural compounds. We found that oblongifolin C (OC), a natural compound extracted from Garcinia yunnanensis Hu, is an effective inhibitor of metastasis in ...
Wang X +9 more
europepmc +4 more sources