Results 151 to 160 of about 63,662 (384)

The N6-Methyladenosine (m6A) Methylation Gene YTHDF1 Reveals a Potential Diagnostic Role for Gastric Cancer

Cancer Management and Research, 2020
Tong Liu,1 Sheng Yang,1 Yan-ping Cheng,1 Xiao-ling Kong,1 Dan-dan Du,1 Xian Wang,1 Yun-fei Bai,2 Li-hong Yin,1 Yue-pu Pu,1 Ge-yu Liang1 1Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast ...
Liu T, Yang S, Cheng YP, Kong XL, Du DD, Wang X, Bai YF, Yin LH, Pu YP, Liang GY   +9 more
doaj  

The second moment of twisted modular L-functions

, 2014
We prove an asymptotic formula with a power saving error term for the (pure or mixed) second moment of central values of L-functions of any two (possibly equal) fixed cusp forms f, g twisted by all primitive characters modulo q, valid for all ...
Blomer, Valentin, Milićević, Djordje
core   +1 more source

tRNA biology in the omics era: Stress signalling dynamics and cancer progression. [PDF]

, 2017
Recent years have seen a burst in the number of studies investigating tRNA biology. With the transition from a gene-centred to a genome-centred perspective, tRNAs and other RNA polymerase III transcripts surfaced as active regulators of normal cell ...
Adelman, Anderson, Anderson, Arimbasseri, Arimbasseri, Barski, Bartholomew, Basturea, Behm-Ansmant, Blanco, Bogenhagen, Boguta, Bonhoure, Canella, Canella, Carlile, Carrire, Chan, Chan, Choi, Clarke, Conti, Core, Cozen, Crick, Danko, David, de Nadal, Deng, Dieci, Dittmar, Dittmar, Duechler, Ebhardt, Flusberg, Gingold, Goodarzi, Goodarzi, Granneman, Grewal, Guenther, Guy, Harismendy, Hiley, Hoagland, Holley, Honda, Hou, Huang, Hussain, Iida, Ishimura, Ivanov, Johnson, Jordan-Pla, Kadaba, Kassavetis, Kedinger, Khoddami, Kim, Kumar, Kumar, Kumar, Kutter, Lampson, Laplante, Li, Li, Lin, Linder, Liu, Liu, Lowe, Lund, Mahlab, Marchand, Mayer, Michels, Moqtaderi, Moqtaderi, Nagarajavel, Nedialkova, Noma, Oler, Oler, Orioli, Orioli, Pang, Pavesi, Pavon-Eternod, Pavon-Eternod, Percudani, Pershing, Phizicky, Pombo, Pugh, Qian, Raha, Renaud, Rhee, Rideout, Roberts, Roeder, Ross, Rudolph, Ryvkin, Saikia, Saikia, Sakurai, Sakurai, Schaefer, Schmitt, Schwartz, Shor, Shukla, Simms, Sutherland, Thurman, Torres, Torres, Turowski, Vannini, Varshney, Vilfan, Weinmann, White, Zheng, Zhou   +127 more
core   +1 more source

Hepatocyte BPGM Induces RET Lactylation and Macrophage Reprogramming to Promote Tumorigenesis in Hepatocellular Carcinoma

Advanced Science, EarlyView.
Mechanistic schematic diagram.BPGM promotes the expression level of RET by increasing the lactylation of RET‐K549 and inhibiting its ubiquitination levels in HCC cells. Furthermore, BPGM in HCC cells could also promote M2 polarization in macrophages through lactate secretion. Both of the mechanisms could promote the progression of HCC. ABSTRACT Aerobic
Jiajia Zhang, Lu Shi, Liangliang Lin, Yang Zhang, Miao Zhang, Lili Wu, Yong Xia, Yaqiong Zhang, Peng Han, Likun Zhuang, Liang Shi   +10 more
wiley   +1 more source

Associated Production of Bottomonia and Higgs Bosons at Hadron Colliders [PDF]

, 2004
We study the associated production of bottomonia and Higgs bosons at hadron colliders within the factorization formalism of nonrelativistic quantum chromodynamics providing all contributing partonic cross sections in analytic form.
A. Martin, A. Petrelli, A.K. Leibovich, A.V. Lipatov, B. Abbott, B. Humpert, B.A. Kniehl, B.A. Kniehl, B.A. Kniehl, B.A. Kniehl, B.A. Kniehl, B.A. Kniehl, Bernd A. Kniehl, C. Adloff, C. Adloff, C. Quigg, Caesar P. Palisoc, D. Acosta, D. Acosta, E. Braaten, E. Braaten, E. Braaten, E. Braaten, E. Braaten, E. Eichten, E. Eichten, E. Eichten, E.J. Eichten, E.L. Berger, F. Abe, F. Abe, F. Abe, F. Abe, F. Abe, F. Halzen, F. Maltoni, F. Yuan, F. Yuan, G.A. Schuler, G.T. Bodwin, G.T. Bodwin, H. Fritzsch, H.L. Lai, J. Abdallah, J.F. Amundson, K. Hagiwara, K. Sridhar, Lennart Zwirner, M. Beneke, M. Beneke, M. Glück, M. Klasen, M. Krämer, M. Spira, N. Marchal, P. Cho, P. Cho, P. Hoyer, Ph. Hägler, Ph. Hägler, R. Baier, R. Baier, R. Barbieri, R. Gastmans, R. Gastmans, S. Abachi, S. Fleming, S.P. Baranov, V. Barger, V.A. Saleev, V.A. Saleev, W. Buchmüller, W.E. Caswell   +72 more
core   +1 more source

m1A‐Dependent TRMT6/61A‐ARG2 Axis Drives Protumorigenic Senescence by Remodeling the Tumor Microenvironment

Advanced Science, EarlyView.
Uncovering a new layer of translational control, this study reveals how TRMT6/TRMT61A‐mediated tRNA‐m1A methylation drives pro‐tumorigenic senescence in colorectal cancer. By selectively enhancing ARG2 translation, this epitranscriptomic axis triggers an NF‐κB‐dependent SASP.
Tuoyang Li, Mingzhe Huang, Jinlin Cai, Xuan Li, Yaokang Xing, Rongzhao He, Zixiao Wan, Yingguo Gan, Ziming Li, Jingrong Weng, Yumo Xie, Yuanhui Wu, Xiaoxia Liu, Xiaolin Wang, Yanxin Luo, Meijin Huang, Jinxin Lin, Huichuan Yu   +17 more
wiley   +1 more source

Dosage Sensing, Threshold Responses, and Epigenetic Memory: A Systems Biology Perspective on Random X‐Chromosome Inactivation

, 2020
X‐chromosome inactivation ensures dosage compensation between the sexes in mammals by randomly choosing one out of the two X chromosomes in females for inactivation.
Barr M. L., Comings D. E., Delbrück M., Rastan S., Rosspopoff O.   +4 more
core   +1 more source

Tumor Extracellular Vesicles lncOSLMT Drives Lung Inflammatory Premetastatic Niche Formation in Osteosarcoma via m6A‐Dependent hnRNPA2B1/COX‐2 Axis

Advanced Science, EarlyView.
Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li, Zehao Guo, Yutong Zou, Jiongfeng Zhang, Jixiang Shi, Xihong Fu, Jian Tu, Hao Yao, Xuanxuan Lu, Lili Wen, Xianbiao Xie   +10 more
wiley   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

METTL3-mediated miR-4534 maturation promotes IVDD progression by targeting the Sirt6-mediated Nrf2/HO-1 pathway

Archives of Medical Science
Introduction Intervertebral disc degeneration (IVDD) is a significant contributor to the development of discogenic low back pain and impairment. Apoptosis and degradation of the extracellular matrix (ECM) have also been reported to be major factors in ...
Bo Ran, Ziqing Yang, Mengzhao Li
doaj   +1 more source