Results 191 to 200 of about 58,783 (322)

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Global DNA and RNA Methylation Signature in Response to Antipsychotic Treatment in First-Episode Schizophrenia Patients

Neuropsychiatric Disease and Treatment
Mary Angelin,1 Padmavathi Gopinath,1 Vijaya Raghavan,1,2 Rangaswamy Thara,2 Faraz Ahmad,3 Arasamabattu Kannan Munirajan,1 Ravi Sudesh4 1Department of Genetics, University of Madras, Dr ALM PG Institute of Basic Medical Sciences, Taramani Campus, Chennai,
Angelin M, Gopinath P, Raghavan V, Thara R, Ahmad F, Munirajan AK, Sudesh R   +6 more
doaj  

Japanese EFL Learners’ Perspectives on the Inclusion of Diverse English Accents in Audio Recordings for Textbooks and Listening Tests

International Journal of Applied Linguistics, EarlyView.
ABSTRACT The use of English accents beyond standard American and British varieties has been increasingly advocated in English language education, particularly in listening instruction and assessment. However, little is known about learners’ perspectives on diverse accents in terms of their use in different types of listening materials.
Ryuichi Suzuki, Tomoko Takenouchi, Shigeru Yamane   +2 more
wiley   +1 more source

m6A partial differential [PDF]

Nature Chemical Biology, 2015
openaire   +1 more source

Epigenetic Regulation in the Pathogenesis of Periodontitis

Journal of Periodontal Research, EarlyView.
The aim of this narrative literature review was to identify epigenetic marks associated with periodontitis and to place them in a biological context. The literature was reviewed based on pre‐defined criteria. Cell type specific chromatin and mRNA modifications were included.
Henrik Dommisch, Arne Sönke Schäfer, Denica Kuzmanova, Dominique S. Michaud   +3 more
wiley   +1 more source

Plant Peptides on the Rise: From Historical Insight to Future Applications

Plant Biotechnology Journal, EarlyView.
ABSTRACT Plant peptides constitute a rapidly expanding class of signalling molecules essential to plant physiology, mediating key processes such as development, stress adaptation, and immune responses. This review traces the history of plant peptide research, from the seminal discovery of systemin to the recent identification of non‐canonical peptides (
Shunxi Wang, Jinghua Zhang, Minghui Chen, Bokai Zhang, Huina Zhao, Liuji Wu   +5 more
wiley   +1 more source

A Natural LTR Retrotransposon Insertion in the Promoter of GhNAC140‐Dt Boosts Cotton Lint Yield

Plant Biotechnology Journal, EarlyView.
ABSTRACT Transposable elements (TEs) are fundamental drivers of crop evolution and domestication. Whereas the underlying mechanisms of TE‐mediated gene activation remain poorly understood. Lint percentage is an important yield component in cotton. Here, we report a retrotransposon insertion in the promoter of GhNAC140‐Dt, a secondary wall NAC encoding ...
Yujia Yu, Xiaoguang Shang, Haitang Wang, Lijie Zhu, Xu Han, Qingfei He, Weixi Li, Yonglin Tan, Guozhong Zhu, Wangzhen Guo   +9 more
wiley   +1 more source

Salt Stress Adaptations in Soybean Involve Alterations in Pre‐mRNA Processing

Plant, Cell &Environment, EarlyView.
ABSTRACT Salt stress can seriously affect plant survival. To adapt to salt stress, plants can alter gene expressions and/or pre‐mRNA processing patterns, or both. Previous studies could not comprehensively profile stress‐responsive pre‐mRNA processing patterns due to limitations in traditional sequencing technologies.
Shoudong Zhang, Zhixia Xiao, Ailin Liu, Dongpeng Ren, Shengjie Chen, Hanxue Zhang, Li Zhang, Zhili Wang, Jun Yang, Hon‐Ming Lam   +9 more
wiley   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source

Epigenetic mechanisms and therapeutic innovations in chronic pain‐associated neuropsychiatric co‐morbidities

British Journal of Pharmacology, Volume 183, Issue 7, Page 1313-1340, April 2026.
Abstract Chronic pain, marked by nociceptive sensitization and maladaptive neuroplasticity, affects 30% of the global population with escalating socioeconomic burdens. Epidemiological data show a 2‐3‐fold increase in neuropsychiatric co‐morbidities among individuals with chronic pain, where epigenetic dysregulation serves as a key mechanism linking ...
Kai Zhang, Sijia Zhu, Na Xing, Zhen Zhou, Jiayi Chen, Tianen Si, Mingrui Li, Lin Jia, Yousef Rastegar‐Kashkooli, Tom J. Wang, Wei Zhu, Jing Li, Chao Jiang, Junmin Wang, Moxin Wu, Xiaoping Yin, Weidong Zang, Jian Wang, Songxue Su   +18 more
wiley   +1 more source