Salivary Extracellular Vesicles: Paradigm Shift in Liquid Biopsy Diagnostics
ABSTRACT Extracellular vesicles (EVs), lipid bilayer nanoparticles released by virtually all cells, serve as essential messengers for intercellular communication. Due to their involvement in several pathophysiological processes, EVs have recently gained considerable attention as potentially diagnostic and prognostic biomarkers for various illnesses ...
Kwanele Xulu +3 more
wiley +1 more source
Immunometabolic reprogramming in rheumatoid arthritis: the epitranscriptomic role of N6-methyladenosine in innate and adaptive immunity. [PDF]
Yang J, Wan L, Chen H, Li S, Zhou Y.
europepmc +1 more source
Comprehensive analysis of m6A RNA methylation regulators and the immune microenvironment in spinal cord injury. [PDF]
Liu X, Hu J, Shi G, Zhu W, Hao Q.
europepmc +1 more source
Intratumoral Microbiota in Tumor: Current Understandings and Future Perspectives
Intratumoral bacteria are emerging as active regulators of cancer evolution rather than bystanders. This review outlines how tumor‐resident microbes drive tumor initiation and growth by inducing genomic instability, epigenetic reprogramming, oncogenic signaling, and chronic inflammation, while promoting metastatic spread via invasion, angiogenesis ...
Jiawei Chen +6 more
wiley +1 more source
N6-methyladenosine modification in the context of viral infection: from molecular mechanism to therapeutic potential. [PDF]
Wu X, Deng Z, Li Y, Shi C.
europepmc +1 more source
Multiple Roles of Protamine Kinase SRPK1 and Phosphatase PP1γ in Sperm Development
ABSTRACT Protein phosphorylation regulates key events of male germ cell differentiation. In the testis, SRPK1 and PP1γ are involved in protamine phosphorylation and dephosphorylation, respectively, and their deregulation is linked to defective chromatin structure and male infertility.
Alberto de la Iglesia +7 more
wiley +1 more source
This study employed an integrated multi‐omics screening strategy incorporating GEO database differential expression analysis, GWAS‐eQTL genetic association analysis, and single‐cell RNA‐seq cell subpopulation localization to identify EPHX2 as a core causal gene in ulcerative colitis (UC).
Tian Dai +8 more
wiley +1 more source
The Role of N<sup>6</sup>-Methyladenosine Modification in Health and Disease. [PDF]
Li L +6 more
europepmc +1 more source
The Role of Long Noncoding RNAs in Modulation of Stress Granules in Cancer
ABSTRACT Stress granules are dynamic cellular structures that arise in response to stress. They play an important role in cancer cell survival by modulating multiple stress responses. Long noncoding RNAs (lncRNAs) have been identified as crucial regulators of stress granule (SG) dynamics, influencing cancer development and treatment resistance. LncRNAs
Nazlı Şevval Menemenli +1 more
wiley +1 more source
HNRNPA2B1 as an emerging coordinator of RNA fate in cancer: m6A reading, RNA export, translation reprogramming, and immune-metabolic adaptation. [PDF]
Bo W, Zhao B, Wang Y, Dai Q.
europepmc +1 more source

