Results 291 to 300 of about 63,662 (384)

Clinofibrate Disrupts the SNORA80B/YTHDC1‐Driven M6A Modification to Suppress Cholesterol Metabolism and Cisplatin Resistance in ESCC

Advanced Science, Volume 13, Issue 3, 14 January 2026.
This study uncovers a non‐canonical role of SNORA80B in ESCC, showing it mediates AR‐driven metabolic reprogramming via N⁶‐methyladenosine (m6A) methylation. By binding YTHDC1, SNORA80B stabilizes cholesterol‐metabolic enzyme mRNAs and promotes tumor progression. The FDA‐approved drug clinofibrate inhibits SNORA80B by disrupting cholesterol homeostasis,
Hongyu Yuan, Ge Ge, LiQiu Liu, Sijun Hu, Miaomiao Tian, Yongzhan Nie, Zitong Zhao, Yongmei Song   +7 more
wiley   +1 more source

Potential value of m6A-related lncRNAs in diagnosis and therapy of pancreatic cancer. [PDF]

Discov Oncol
Wu L, Zhang Y, Wu D.
europepmc   +1 more source

METTL3-m6A methylation inhibits the proliferation and viability of type II alveolar epithelial cells in acute lung injury by enhancing the stability and translation efficiency of Pten mRNA [PDF]

Qiuyun Wang, Jie Shen, Shiyuan Luo, Zhize Yuan, Shiyou Wei, Qiang Li, Qianzi Yang, Yan Luo, Lei Zhuang   +8 more
openalex   +1 more source

Site‐Specific Mitochondrial RNA N1‐Methyladenosine Demethylation via an Engineered MTS‐PUF‐ALKBH3 Fusion Protein

Advanced Science, Volume 13, Issue 1, 5 January 2026.
A CRISPR‐free mitochondrial RNA m1A demethylation (MRD) editor combining MTS, PUF proteins, and ALKBH3 enables precise m1A removal from mitochondrial mRNA and tRNA, which influences mitochondrial protein levels, cellular proliferation, ATP production, and mitochondrial respiration. Subsequently, in vivo demethylation of the m1A modification is achieved
Xiangrui Li, Deqiang Kong, Hongmei Liu, Jie Yang, Jiale Zhou, Yuqiang Qian, Ding Zhao, Jinze Li, Xinyu Wu, Tao Zhang, Xiaodi Sun, Yang Han, Liangxue Lai, Zhanjun Li   +13 more
wiley   +1 more source

Unraveling the significance of methyltransferase like-3 in the pathogenesis of gastrointestinal tumors: A review. [PDF]

Medicine (Baltimore)
Xiong L, Ai Q, Liu C, Yang W, Liu L, Li GQ.   +5 more
europepmc   +1 more source

Temporal Stretch‐Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection

Advanced Science, Volume 13, Issue 5, 27 January 2026.
Cyclic stretching of fibroblasts triggers coordinated nuclear mechanosensing events, including calcium ion release, perinuclear actin assembly, emerin translocation, and H3K9me3 loss, increasing chromatin accessibility for specific genes related to mechanotransduction and repair.
Hye‐Won Shim, Ji‐Young Yoon, Hwalim Lee, Shanika Karunasagara, Cheng Ji Li, Yongdae Shin, Sukbum Hong, Dong‐Joon Lee, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +10 more
wiley   +1 more source

YTHDC1-Mediated m⁶A Modification of MAGI3 mRNA Regulates Proliferation and Differentiation of Myoblasts. [PDF]

J Agric Food Chem
Chen Q, He S, Xue X, Zhang W, Li H, He X, Pu Y, Ma Y, Jiang L, Zhao Y, Zhao Q.   +10 more
europepmc   +1 more source

Ythdc1‐p300‐Klf5 Complex‐Mediated Golgi Dysfunction Promotes Aortic Aneurysm

Advanced Science, Volume 13, Issue 4, 19 January 2026.
In their Research Article (DOI: https://doi.org/10.1002/advs.202512116* lF: 14.1 Q1), Wenli Wang and co‐workers identifies a novel lncRNA m6A modification‐dependent regulatory mechanism of vascular homeostasis, and constructs a predictive model for post‐operative short‐term death based on AD patient's features, providing a platform to be able to ...
Wen‐Li Wang, Zhi‐Xue Song, Si‐Ming Bu, Yi‐Mei Liu, Qing Li, Wen‐Xia Zhang, Xu‐Rong Sun, Xin Zhang, Yu‐Xuan Xiao, Di Bo, Xu‐Bin Miao, Chao Liu, Xin‐Hua Zhang, Lei Zheng, Hong‐Ye Zhao, Bao‐Lian Zhang, Wen Jia, Kui Chi, Yu Liu, Yong‐Bo Zhao, Bin Zheng, Dong Ma, Jin‐Kun Wen   +22 more
wiley   +1 more source

Transcriptome-Wide Identification and Analysis Reveals m⁶A Regulation of Porcine Intestinal Epithelial Cells Under TGEV Infection. [PDF]

Vet Sci
Liu Y, Zhou G, Wang G, Wu Z.
europepmc   +1 more source

The m6A reader IGF2BP3 promotes LIHC progression by enhancing MCM10 stability [PDF]

Lianwu Zhao, Hongyan Huang, Linfei Luo, Zixiang Huang, Zhengqiang Wu, Fenfen Wang, Zhili Wen   +6 more
openalex   +1 more source