Results 191 to 200 of about 937,277 (225)

RNA m6A methylation across the transcriptome [PDF]

Molecular Cell, 2023
Since the early days of foundational studies of nucleic acids, many chemical moieties have been discovered to decorate RNA and DNA in diverse organisms. In mammalian cells, one of these chemical modifications, N6-methyl adenosine (m6A), is unique in a way that it is highly abundant not only on RNA polymerase II (RNAPII) transcribed, protein-coding ...
Erdem, Sendinc, Yang, Shi
exaly   +6 more sources

Role of m6A RNA Methylation in Thyroid Cancer Cell Lines [PDF]

International Journal of Molecular Sciences, 2022
N6-methyladenosine (m6A) is the most abundant internal modification of RNA in eukaryotic cells, and, in recent years, it has gained increasing attention. A good amount of data support the involvement of m6A modification in tumorigenesis, tumor progression, and metastatic dissemination.
Lorenzo Allegri, Catia Mio, Federica Baldan   +2 more
exaly   +5 more sources

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Gene expression regulation mediated through reversible m6A RNA methylation

Nature Reviews Genetics, 2014
Ye Fu, Dan Dominissini, Chuan He
exaly   +2 more sources

m6A RNA Methylation and Implications for Hepatic Lipid Metabolism

DNA and Cell Biology
This review presents a summary of recent progress in research on the N6-methyladenosine (m6A) modification and regulatory roles in hepatic lipid metabolism.
Xinyue Ming, Shi-Rui Chen, Hui-Juan Li, Yun Wang, Le Zhou, Yun-Cheng Lv   +5 more
semanticscholar   +3 more sources

m6A RNA methylation, a new hallmark in virus-host interactions [PDF]

Journal of General Virology, 2017
The role of m6A methylation of RNA has remained elusive for decades, however recent technological advances are now allowing the mapping of the m6A methylation landscape at nucleotide level.
Alessia Ruggieri, Nicolas Locker, Michèle Brocard   +2 more
exaly   +2 more sources

Role of m6A RNA Methylation in Ischemic Stroke

Molecular Neurobiology
Ischemic stroke is a prominent contributor to global morbidity and mortality rates. The intricate and diverse mechanisms underlying ischemia-reperfusion injury remain poorly comprehended. RNA methylation, an emerging epigenetic modification, plays a crucial role in regulating numerous biological processes, including immunity, DNA damage response ...
Yayun Xu, Wenqiang Liu, Li-Jie Ren
semanticscholar   +3 more sources

RNA m6A methylation regulators in sepsis

Molecular and Cellular Biochemistry, 2023
N6-methyladenosine (m6A) modification is a class of epitope modifications that has received significant attention in recent years, particularly in relation to its role in various diseases, including sepsis. Epigenetic research has increasingly focused on m6A modifications, which is influenced by the dynamic regulation of three protein types: ‟Writers" (
Lin, Zhu, Hairong, Zhang, Xiaoyu, Zhang, Lei, Xia   +3 more
openaire   +2 more sources

The potential role of m6A RNA methylation in diabetic retinopathy

Experimental Eye Research, 2021
Diabetic retinopathy (DR), a major microvascular complication of diabetes, affects most diabetic individuals and has become the leading cause of vision loss. Metabolic memory associated with diabetes retains the risk of disease occurrence even after the termination of glycemic insult.
Nidhi Kumari, Aditi Karmakar, Md Maqsood Ahamad Khan, Senthil Kumar Ganesan   +3 more
openaire   +2 more sources

m6A RNA methylation orchestrates transcriptional dormancy during paused pluripotency

Nature Cell Biology, 2023
Embryos across metazoan lineages can enter reversible states of developmental pausing, or diapause, in response to adverse environmental conditions. The molecular mechanisms that underlie this remarkable dormant state remain largely unknown. Here we show
É. Collignon, Brandon Cho, G. Furlan, Julie Fothergill-Robinson, S. Martin, Sarah A. McClymont, Robert L. Ross, P. Limbach, M. Ramalho-Santos   +8 more
semanticscholar   +1 more source

Lnc-HZ01 with m6A RNA methylation inhibits human trophoblast cell proliferation and induces miscarriage by up-regulating BPDE-activated lnc-HZ01/MXD1 positive feedback loop.

Science of the Total Environment, 2021
Environmental BaP (benzo(a)pyrene) and its metabolite BPDE (benzo(a)pyrene-7,8-dihydrodiol-9,10-epoxide) inhibit proliferation of human villous trophoblast cells, which might further induce recurrent miscarriage (RM).
Zhongyan Xu, Peng Tian, Jia-Rong Guo, Chen-Yang Mi, T. Liang, Jiayu Xie, Wen-Xin Huang, Meng-Yuan Dai, Weina Chen, Hui-Dong Zhang   +9 more
semanticscholar   +1 more source