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RNA m6A methylation at the juxtaposition of apoptosis and RNA therapeutics
Trends in Cell BiologyTargeting RNA m6A marks in apoptosis-related transcripts holds promise for RNA therapeutics. However, pathway-specific RNA m6A sites on pro- or antiapoptotic transcripts have not been fully unveiled, let alone characterized. This article summarizes the current knowledge and gaps in the cellular response modulated by apoptotic stimulus-specific RNA m6A ...
Bünyamin Akgül +2 more
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Journal of Hazardous Materials, 2023
A growing body of evidence indicates that ambient fine particle matter (PM2.5) exposure inhibits heart development, but the underlying mechanisms remain elusive.
Cheng Ji +7 more
semanticscholar +1 more source
A growing body of evidence indicates that ambient fine particle matter (PM2.5) exposure inhibits heart development, but the underlying mechanisms remain elusive.
Cheng Ji +7 more
semanticscholar +1 more source
Relative Quantification of Residue-Specific m6A RNA Methylation Using m6A-RT-QPCR
2021Technological advances in high-throughput sequencing in combination with antibody enrichment and/or induced nucleotide-specific chemical modifications have accelerated the mapping of epitranscriptomic modifications. However, site-specific detection and quantification of m6A are still technically challenging.
Ane, Olazagoitia-Garmendia +1 more
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The epigenetic approach of varicocele: a focus on sperm DNA and m6A-RNA methylation.
Human Reproduction UpdateBACKGROUND Varicocele is an abnormal dilation and torsion of the pampiniform venous plexus in the scrotum due to venous reflux, primarily affecting the left side. It affects 15% of men and is a prevalent contributor to male infertility.
Nushin Naderi +2 more
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m6A RNA methylation: The latent string-puller in fibrosis
Life SciencesFibrosis is a pathological phenomenon characterized by the aberrant accumulation of extracellular matrix (ECM) in tissues. Fibrosis is a universally age-related disease involving that many organs and is the final stage of many chronic inflammatory diseases, which often threaten the patient's health.
Xinglan, He +7 more
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RNA Modification by m6A Methylation in Cardiovascular Disease
2021Cardiovascular disease is currently the leading cause of death worldwide, and its underlying regulatory mechanisms remain largely unknown. N6-Methyladenosine (m6A) RNA methylation is an epigenetic modification involved in the splicing, nuclear export, translational regulation, and degradation of RNA.
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RNA m6A methylation in psychiatric disorders.
EC psychology and psychiatryThis comprehensive review introduces the features of m6A modification and its role in neuropsychiatric disorders. The research findings suggest that m6A modifications and their regulators play a critical role in the occurrence and development of major psychiatric disorders, especially Alzheimer's disease, affecting synaptic protein synthesis, subtype ...
Qiao, Mao +7 more
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RNA methylation and breast cancer: insights into m6A, m7G and m5C
Molecular Biology ReportsBreast cancer remains the most commonly diagnosed cancer in female worldwide, marked by its molecular diversity and complex subtypes. Despite progress in targeted therapies, tumor heterogeneity and treatment resistance continue to present major challenges. Recent studies emphasize the crucial role of RNA modifications in cancer biology, with nearly 200
Yuhan, Dai +6 more
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RNA m6A methylation and regulatory proteins in pulmonary arterial hypertension
Hypertension Researchm6A (N6‑methyladenosine) is the most common and abundant apparent modification in mRNA of eukaryotes. The modification of m6A is regulated dynamically and reversibly by methyltransferase (writer), demethylase (eraser), and binding protein (reader).
Zhe, Wang +9 more
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