Results 1 to 10 of about 36,088 (121)

Defects in DNA damage signaling and cell cycle checkpoints in a mouse model of Rhno1 deletion [PDF]

Cell Death Discovery
In response to DNA damage or DNA replication stress, cells activate signaling pathways dependent on the kinase, ATR (Ataxia Telangiectasia and Rad3-Related).
Joonyoung Her, Adithi Santhosh, Yanira Gonzalez-Rodriguez, Niphat Jirapongwattana, Channabasavaiah B. Gurumurthy, Adam R. Karpf, Samuel F. Bunting   +6 more
doaj   +2 more sources

Deciphering cell cycle organization of Toxoplasma endodyogeny [PDF]

mBio
In this study, we report the atypical cell cycle organization of the unicellular eukaryotic pathogen Toxoplasma gondii. The remarkably flexible cell division of T.
Mrinalini Batra, Clem Marsilia, Danya Awshah, Lauren M. Hawkins, Chengqi Wang, Dale Chaput, Daria A. Naumova, Elena S. Suvorova   +7 more
doaj   +2 more sources

Checkpoint inhibition of origin firing prevents inappropriate replication outside of S-phase

eLife, 2021
Checkpoints maintain the order of cell cycle events during DNA damage or incomplete replication. How the checkpoint response is tailored to different phases of the cell cycle remains poorly understood.
Mark C Johnson, Geylani Can, Miguel Monteiro Santos, Diana Alexander, Philip Zegerman   +4 more
doaj   +1 more source

Baicalein Induces G₂/M Cell Cycle Arrest Associated with ROS Generation and CHK2 Activation in Highly Invasive Human Ovarian Cancer Cells

Molecules, 2023
Ovarian cancer is a lethal gynecological cancer because drug resistance often results in treatment failure. The CHK2, a tumor suppressor, is considered to be an important molecular target in ovarian cancer due to its role in DNA repair.
Tzu-Chao Chuang, Wei-Syun Shao, Shih-Chung Hsu, Shou-Lun Lee, Ming-Ching Kao, Vinchi Wang   +5 more
doaj   +1 more source

Sulforaphane-induced G2/M Phase Cell Cycle Arrest Involves Checkpoint Kinase 2-mediated Phosphorylation of Cell Division Cycle 25C [PDF]

Journal of Biological Chemistry, 2004
Previously, we showed that sulforaphane (SFN), a naturally occurring cancer chemopreventive agent, effectively inhibits proliferation of PC-3 human prostate cancer cells by causing caspase-9- and caspase-8-mediated apoptosis. Here, we demonstrate that SFN treatment causes an irreversible arrest in the G(2)/M phase of the cell cycle.
Shivendra V, Singh, Anna, Herman-Antosiewicz, Ajita V, Singh, Karen L, Lew, Sanjay K, Srivastava, Ravindra, Kamath, Kevin D, Brown, Lin, Zhang, Rajasekaran, Baskaran   +8 more
openaire   +2 more sources

Dietary Isothiocyanates Inhibit Caco-2 Cell Proliferation and Induce G2/M Phase Cell Cycle Arrest, DNA Damage, and G2/M Checkpoint Activation [PDF]

The Journal of Nutrition, 2004
Benzyl isothiocyanate and phenethyl isothiocyanate, two aromatic phytochemicals present in substantial concentrations in edible vegetables of the genus Brassica, were investigated for their effects on Caco-2 cell proliferation. Benzyl and phenethyl isothiocyanate inhibited DNA synthesis, with 50% inhibitory concentrations of 5.1 and 2.4 micromol/L ...
Visanji, JM, Duthie, SJ, Pirie, L, Thompson, DG, Padfield, PJ.   +4 more
openaire   +3 more sources

Phosphorylation of CDC25C by AMP-activated protein kinase mediates a metabolic checkpoint during cell-cycle G2/M-phase transition [PDF]

Journal of Biological Chemistry, 2018
From unicellular to multicellular organisms, cell-cycle progression is tightly coupled to biosynthetic and bioenergetic demands. Accumulating evidence has demonstrated the G1/S-phase transition as a key checkpoint where cells respond to their metabolic status and commit to replicating the genome.
Shen, Yuqing, Sherman, John William, Chen, Xuyong, Wang, Ruoning   +3 more
openaire   +2 more sources

A detailed map of coupled circadian clock and cell cycle with qualitative dynamics validation

BMC Bioinformatics, 2021
Background The temporal coordination of biological processes by the circadian clock is an important mechanism, and its disruption has negative health outcomes, including cancer.
Adrien Rougny, Loïc Paulevé, Michèle Teboul, Franck Delaunay   +3 more
doaj   +1 more source

The Effect of Radiotherapy on Cell Survival and Inflammatory Cytokine and Chemokine Secretion in a Co-Culture Model of Head and Neck Squamous Cell Carcinoma and Normal Cells

Biomedicines, 2023
Radiotherapy (RT) is one of the main treatments for head and neck squamous cell carcinomas (HNSCCs). Unfortunately, radioresistance is observed in many cases of HNSCCs. The effectiveness of RT depends on both the direct effect inducing cell death and the
Sybilla Matuszczak, Krzysztof Szczepanik, Aleksandra Grządziel, Alina Drzyzga, Tomasz Cichoń, Justyna Czapla, Ewelina Pilny, Ryszard Smolarczyk   +7 more
doaj   +1 more source

The Saccharomyces cerevisiae RAD9 cell cycle checkpoint gene is required for optimal repair of UV-induced pyrimidine dimers in both G1 and G2/M phases of the cell cycle [PDF]

Nucleic Acids Research, 2001
Cells respond to DNA damage by activating both cellular growth arrest and DNA repair processes. In Saccharomyces cerevesiae the RAD9 gene controls DNA damage-mediated cell cycle arrest that is known to allow efficient repair. To ascertain whether RAD9 plays a role in DNA repair per se, the removal of UV-induced photolesions was assessed in synchronized
N M, Al-Moghrabi, I S, Al-Sharif, A, Aboussekhra   +2 more
openaire   +2 more sources