MAPKAP Kinase-2 Is a Cell Cycle Checkpoint Kinase that Regulates the G2/M Transition and S Phase Progression in Response to UV Irradiation [PDF]
Molecular Cell, 2005 The cellular response to DNA damage is mediated by evolutionarily conserved Ser/Thr kinases, phosphorylation of Cdc25 protein phosphatases, binding to 14-3-3 proteins, and exit from the cell cycle. To investigate DNA damage responses mediated by the p38/stress-activated protein kinase (SAPK) axis of signaling, the optimal phosphorylation motifs of ...
Manke, Isaac A. +5 more
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4-Hydroxynonenal Induces G2/M Phase Cell Cycle Arrest by Activation of the Ataxia Telangiectasia Mutated and Rad3-related Protein (ATR)/Checkpoint Kinase 1 (Chk1) Signaling Pathway [PDF]
Journal of Biological Chemistry, 2013 4-Hydroxynonenal (HNE) has been widely implicated in the mechanisms of oxidant-induced toxicity, but the detrimental effects of HNE associated with DNA damage or cell cycle arrest have not been thoroughly studied. Here we demonstrate for the first time that HNE caused G2/M cell cycle arrest of hepatocellular carcinoma HepG2 (p53 wild type) and Hep3B ...
Pankaj, Chaudhary +5 more
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MAP Kinase Is Required for the Spindle Assembly Checkpoint but Is Dispensable for the Normal M Phase Entry and Exit in Xenopus Egg Cell Cycle Extracts [PDF]
The Journal of Cell Biology, 1997 In Xenopus laevis egg cell cycle extracts that mimic early embryonic cell cycles, activation of MAP kinase and MAP kinase kinase occurs in M phase, slightly behind that of maturation promoting factor. To examine the possible role of MAP kinase in the in vitro cell cycle, we depleted the extracts of MAP kinase by using anti–Xenopus MAP kinase antibody ...
K, Takenaka, Y, Gotoh, E, Nishida
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DNA lesions induced by replication stress trigger mitotic aberration and tetraploidy development. [PDF]
PLoS ONE, 2010 During tumorigenesis, cells acquire immortality in association with the development of genomic instability. However, it is still elusive how genomic instability spontaneously generates during the process of tumorigenesis.
Yosuke Ichijima +10 more
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Naïve B cells with low differentiation improve the immune reconstitution of HIV-infected patients
iScience, 2022 Summary: Incomplete immune reconstitution happens in some HIV-infected patients who have achieved persistent viral suppression under antiretroviral therapy (ART). We performed single-cell RNA sequencing for peripheral blood mononuclear cells to analyze B
Jie Jia +8 more
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Military Medical Research, 2022 Background The cell cycle is at the center of cellular activities and is orchestrated by complex regulatory mechanisms, among which transcriptional regulation is one of the most important components.
Chun-Xiao Li +13 more
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Pathways for Genome Integrity in G2 Phase of the Cell Cycle
Biomolecules, 2012 The maintenance of genome integrity is important for normal cellular functions, organism development and the prevention of diseases, such as cancer. Cellular pathways respond immediately to DNA breaks leading to the initiation of a multi-facetted DNA ...
Claus Storgaard Sørensen +2 more
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Cell cycle regulation and hematologic malignancies
Blood Science, 2019 . A complex network precisely regulates the cell cycle through the G1, S, G2, and M phases and is the basis for cell division under physiological and pathological conditions.
Yun Dai +3 more
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PLoS Computational Biology, 2014 A fundamental property of cell populations is their growth rate as well as the time needed for cell division and its variance. The eukaryotic cell cycle progresses in an ordered sequence through the phases G1, S, G2, and M, and is regulated by ...
Tom Serge Weber +4 more
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O-Linked N-Acetylglucosamine Transiently Elevates in HeLa Cells during Mitosis
Molecules, 2018 O-linked N-acetylglucosamine (O-GlcNAc) is a dynamic post-translational modification of serine and threonine residues on nuclear and cytoplasmic proteins.
Viktória Fisi +5 more
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