Bottleneck genes and community structure in the cell cycle network of S. pombe.
PLoS Computational Biology, 2007 The identification of cell cycle-related genes is still a difficult task, even for organisms with relatively few genes such as the fission yeast. Several gene expression studies have been published on S.
Cécile Caretta-Cartozo +3 more
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Human surfactant protein D alters oxidative stress and HMGA1 expression to induce p53 apoptotic pathway in eosinophil leukemic cell line. [PDF]
PLoS ONE, 2013 Surfactant protein D (SP-D), an innate immune molecule, has an indispensable role in host defense and regulation of inflammation. Immune related functions regulated by SP-D include agglutination of pathogens, phagocytosis, oxidative burst, antigen ...
Lakshna Mahajan +10 more
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β-TrCP- and Casein Kinase II-Mediated Degradation of Cyclin F Controls Timely Mitotic Progression
Cell Reports, 2018 Summary: Orderly progressions of events in the cell division cycle are necessary to ensure the replication of DNA and cell division. Checkpoint systems allow the accurate execution of each cell-cycle phase.
Ioanna Mavrommati +10 more
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Increased ASF1B Expression Correlates With Poor Prognosis in Patients With Gliomas
Frontiers in Oncology, 2022 BackgroundSeveral studies have suggested that anti-silencing function 1 B (ASF1B) can serve as a good potential marker for predicting tumor prognosis.
Huaxin Zhu +7 more
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The G2 checkpoint—a node‐based molecular switch
FEBS Open Bio, 2017 Tight regulation of the eukaryotic cell cycle is paramount to ensure genomic integrity throughout life. Cell cycle checkpoints are present in each phase of the cell cycle and prevent cell cycle progression when genomic integrity is compromised.
Mark C. deGooijer +5 more
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Tousled-like kinase-dependent phosphorylation of Rad9 plays a role in cell cycle progression and G2/M checkpoint exit. [PDF]
PLoS ONE, 2013 Genomic integrity is preserved by checkpoints, which act to delay cell cycle progression in the presence of DNA damage or replication stress. The heterotrimeric Rad9-Rad1-Hus1 (9-1-1) complex is a PCNA-like clamp that is loaded onto DNA at structures ...
Ryan Kelly, Scott K Davey
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Base excision repair of ionizing radiation-induced DNA damage in G1 and G2 cell cycle phases
Cancer Cell International, 2007 Background Major genomic surveillance mechanisms regulated in response to DNA damage exist at the G1/S and G2/M checkpoints. It is presumed that these delays provide time for the repair of damaged DNA. Cells have developed multiple DNA repair pathways to
Chaudhry M Ahmad
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Liver Research, 2022 Background: Hepatocellular carcinoma (HCC) is a leading cause of cancer-related death worldwide. The development of biomarkers for early detection and monitoring of HCC has not shown significant progress.
Fan Yang +7 more
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Cell Division, 2007 Considerable evidence has accumulated suggesting that cancer has genetic origin, based on the development of genomic alterations, such as deletions, mutations, and/or methylations in critical genes for homeostasis of cellular functions, including cell ...
Croce Carlo M +2 more
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Expanded CAG/CTG repeat DNA induces a checkpoint response that impacts cell proliferation in Saccharomyces cerevisiae. [PDF]
PLoS Genetics, 2011 Repetitive DNA elements are mutational hotspots in the genome, and their instability is linked to various neurological disorders and cancers. Although it is known that expanded trinucleotide repeats can interfere with DNA replication and repair, the ...
Rangapriya Sundararajan +1 more
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