Results 31 to 40 of about 36,088 (121)

A Nicotinamide Phosphoribosyltransferase Inhibitor, FK866, Suppresses the Growth of Anaplastic Meningiomas and Inhibits Immune Checkpoint Expression by Regulating STAT1

open access: yesFrontiers in Oncology, 2022
Anaplastic meningioma is classified as a World Health Organization (WHO) grade III tumor and shows a strong tendency to recur. Although the incidence of anaplastic meningioma is low, the high rate of recurrence and death still makes treatment a challenge.
Yuxuan Deng   +11 more
doaj   +1 more source

Drug-induced cell cycle modulation leading to cell-cycle arrest, nuclear mis-segregation, or endoreplication

open access: yesBMC Cell Biology, 2011
Background Cancer cell responses to chemotherapeutic agents vary, and this may reflect different defects in DNA repair, cell-cycle checkpoints, and apoptosis control.
Kobayashi Tamiyo   +3 more
doaj   +1 more source

Phospholipase A/acyltransferase 4 is a prognostic biomarker and correlated with immune infiltrates in pancreatic cancer

open access: yesHeliyon, 2022
Background: Phospholipase A/acyltransferase (PLAAT) family exhibits O- and N-acyltransferase activity and biosynthesize N-acylated ethanolamine phospholipids.
Tian-Hao Li   +5 more
doaj   +1 more source

Raptor is phosphorylated by cdc2 during mitosis. [PDF]

open access: yesPLoS ONE, 2010
The appropriate control of mitotic entry and exit is reliant on a series of interlocking signaling events that coordinately drive the biological processes required for accurate cell division.
Dana M Gwinn   +2 more
doaj   +1 more source

Role of PP2Cα in cell growth, in radio- and chemosensitivity, and in tumorigenicity

open access: yesMolecular Cancer, 2007
Background PP2Cα is the representative member of the type 2C family of protein phosphatases, and it has recently been implicated in the regulation of p53-, TGFβ-, cyclin-dependent kinase- and apoptosis-signaling.
Slobodin Boris   +6 more
doaj   +1 more source

Schistosoma mansoni polo-like kinases and their function in control of mitosis and parasite reproduction

open access: yesAnais da Academia Brasileira de Ciências, 2011
Polo-like kinases are important regulators of cell cycle progression and mitosis. They constitute a family of conserved serine/threonine kinases which are highly related in their catalytic domains and contain polo boxes involved in protein-protein ...
Colette Dissous   +2 more
doaj   +1 more source

MAP kinase meets mitosis: A role for Raf Kinase Inhibitory Protein in spindle checkpoint regulation

open access: yesCell Division, 2007
Raf Kinase Inhibitory Protein (RKIP) is an evolutionarily conserved protein that functions as a modulator of signaling by the MAP kinase cascade.
Rosner Marsha
doaj   +1 more source

LncRNA ELF3-AS1 is a Prognostic Biomarker and Correlated with Immune Infiltrates in Hepatocellular Carcinoma

open access: yesCanadian Journal of Gastroenterology and Hepatology, 2021
Background. Expression of long noncoding RNA (lncRNA) ELF3 antisense RNA 1 (ELF3-AS1) is observed in some cancers, while its role in hepatocellular carcinoma (HCC) is unclear. The study aimed to investigate the relationship between ELF3-AS1 and HCC based
Tianming Chen   +3 more
doaj   +1 more source

An alternative microRNA-mediated post-transcriptional regulation of GADD45A by p53 in human non-small-cell lung cancer cells

open access: yesScientific Reports, 2017
GADD45A (growth arrest and DNA damage inducible alpha), a stress response gene induced by genotoxic and nongenotoxic stresses, is implicated in various key processes, including the control of cell cycle checkpoints and DNA repair.
Jie Li   +14 more
doaj   +1 more source

The budding yeast protein Chl1p is required for delaying progression through G1/S phase after DNA damage

open access: yesCell Division, 2021
Background The budding yeast protein Chl1p is a nuclear protein required for sister-chromatid cohesion, transcriptional silencing, rDNA recombination, ageing and plays an instrumental role in chromatin remodeling.
Muhseena N. Katheeja   +2 more
doaj   +1 more source

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