Results 41 to 50 of about 36,088 (121)

Overview of Roles of Novel Components in the Regulation of DNA Damage Repair in BRCA1-Deficient Cancers: An Update

DNA
Cancers that arise from germline mutations of breast cancer associated gene 1 (BRCA1), which is a crucial player in homologous recombination (HR) DNA repair, are vulnerable to DNA-damaging agents such as platinum and PARP inhibitors (PARPis).
Nhat Nguyen, Dominic Arris, Manh Tien Tran   +2 more
doaj   +1 more source

In vivo importance of homologous recombination DNA repair for mouse neural stem and progenitor cells.

PLoS ONE, 2012
We characterized the in vivo importance of the homologous recombination factor RAD54 for the developing mouse brain cortex in normal conditions or after ionizing radiation exposure.
Laure Rousseau, Olivier Etienne, Telma Roque, Chantal Desmaze, Céline Haton, Marc-André Mouthon, Jacqueline Bernardino-Sgherri, Jeroen Essers, Roland Kanaar, François D Boussin   +9 more
doaj   +1 more source

Decreased Expression of a Novel lncRNA FAM181A-AS1 is Associated with Poor Prognosis and Immune Infiltration in Lung Adenocarcinoma

Pharmacogenomics and Personalized Medicine, 2022
Weiquan Liang,1,* Yiyu Lu,2,* Xingxi Pan,2,* Yunxiang Zeng,1 Weiqiang Zheng,1 Yiran Li,1 Yuanhang Nie,1 Dongbing Li,3 Dongliang Wang3 1Department of Respiratory and Critical Care Medicine, The Second People’s Hospital of Foshan (Affiliated ...
Liang W, Lu Y, Pan X, Zeng Y, Zheng W, Li Y, Nie Y, Li D, Wang D   +8 more
doaj  

The molecular basis of genistein-induced mitotic arrest and exit of self-renewal in embryonal carcinoma and primary cancer cell lines

BMC Medical Genomics, 2008
Background Genistein is an isoflavonoid present in soybeans that exhibits anti-carcinogenic properties. The issue of genistein as a potential anti-cancer drug has been addressed in some papers, but comprehensive genomic analysis to elucidate the ...
Lehrach Hans, Jung Marc, Regenbrecht Christian RA, Adjaye James   +3 more
doaj   +1 more source

Targeting cancer-associated fibroblasts/tumor cells cross-talk inhibits intrahepatic cholangiocarcinoma progression via cell-cycle arrest

Journal of Experimental & Clinical Cancer Research
Background Cancer-associated fibroblasts (CAFs), mainly responsible for the desmoplastic reaction hallmark of intrahepatic Cholangiocarcinoma (iCCA), likely have a role in tumor aggressiveness and resistance to therapy, although the molecular mechanisms ...
Serena Mancarella, Isabella Gigante, Elena Pizzuto, Grazia Serino, Alberta Terzi, Francesco Dituri, Eugenio Maiorano, Leonardo Vincenti, Mario De Bellis, Francesco Ardito, Diego F. Calvisi, Gianluigi Giannelli   +11 more
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Wee1 inhibitor PD0166285 sensitized TP53 mutant lung squamous cell carcinoma to cisplatin via STAT1

Cancer Cell International
Background Lung squamous cell carcinoma (LUSCs) is associated with high mortality (20–30%) and lacks of effective treatments. Almost all LUSC exhibit somatic mutations in TP53. Wee1, a tyrosine kinase, regulates the cell cycle at the G2/M checkpoint.
Qi Li, Wenjie Yang, Qingyi Zhang, Daoming Zhang, Jun Deng, Binxin Chen, Ping Li, Huanqi Zhang, Yiming Jiang, Yangling Li, Bo Zhang, Nengming Lin   +11 more
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RBM15 is a novel prognostic biomarker and correlates with immune cell infiltration in lung adenocarcinoma

Journal of Cardiothoracic Surgery
Background and aims This study aimed to evaluate RBM15 gene expression and the potential effects as a biomarker in LUAD progression. Materials and methods The RNA sequencing (RNA-seq) data and clinical data of patients with LUAD were acquired from The ...
Mingsheng Ma, Wei Wang, Li Li, Xiaoyan Wang, Qiubo Huang, Chen Zhou, Lianhua Ye   +6 more
doaj   +1 more source

Cell cycle deregulation by the HBx protein of hepatitis B virus

Iatreia, 2007
<p class="MsoNormal"><span style="font-size: 10pt; font-family: QuorumITCbyBT-Book">Cell cycle control by oncogenic viruses usually involves disruption of the normal restraints on cellular proliferation via abnormal proteolytic degradation ...
Vijay Kumar
doaj  

P14 | THE ROLE OF CHROMATIN REORGANIZATION IN HYPOXIA ADAPTATION

European Journal of Histochemistry
The spatial organization of the cell nucleus bears functional relevance in both maintaining cellular homeostasis and facilitating pathological transformations.
doaj   +1 more source

Tumor cell cycle regulation: integrated perspective of stage characteristics, regulatory networks, and signaling pathway intervention strategies. [PDF]

Mol Biomed
Wan Q, Yang Z, Huang L, Xia Y, Long L, Xu Z, Li J.   +6 more
europepmc   +1 more source