Results 1 to 10 of about 2,657,621 (99)

Normothermic machine perfusion versus static cold storage in donation after circulatory death kidney transplantation: a randomized controlled trial

Nature Network Boston, 2023
Kidney transplantation is the optimal treatment for end-stage renal disease, but it is still severely limited by a lack of suitable organ donors. Kidneys from donation after circulatory death (DCD) donors have been used to increase transplant rates, but ...
S. Hosgood, C. Callaghan, C. Wilson, Laura Smith, J. Mullings, J. Mehew, G. Oniscu, Benedict L. Phillips, L. Bates, M. Nicholson   +9 more
semanticscholar   +1 more source

Hypothermia or Machine Perfusion in Kidney Donors.

New England Journal of Medicine, 2023
BACKGROUND Therapeutic hypothermia in brain-dead organ donors has been shown to reduce delayed graft function in kidney recipients after transplantation.
D. Malinoski, Christina T. Saunders, S. Swain, T. Groat, Patrick R Wood, Jeffrey Reese, Rachel Nelson, Jennifer Prinz, Kate Kishish, Craig Van De Walker, P. Geraghty, Kristine Broglio, C. Niemann   +12 more
semanticscholar   +1 more source

Normothermic Machine Perfusion of Donor Livers for Transplantation in the United States

Annals of Surgery, 2023
Objective: To compare conventional low-temperature storage of transplant donor livers [static cold storage (SCS)] with storage of the organs at physiological body temperature [normothermic machine perfusion (NMP)].
W. Chapman, A. Barbas, A. D’ALESSANDRO, R. Vianna, C. Kubal, P. Abt, C. Sonnenday, R. Barth, J. Alvarez-Casas, H. Yersiz, D. Eckhoff, Robert Cannon, Y. Genyk, L. Sher, A. Singer, Sandy Feng, G. Roll, A. Cohen, M. Doyle, D. Sudan, D. Al‐Adra, Adeel S Khan, V. Subramanian, N. Abraham, K. Olthoff, A. Tekin, Lynn Berg, C. Coussios, Chris Morris, L. Randle, P. Friend, S. Knechtle   +31 more
semanticscholar   +1 more source

Immune cell dynamics deconvoluted by single-cell RNA sequencing in normothermic machine perfusion of the liver

Nature Communications, 2023
Normothermic machine perfusion (NMP) has emerged as an innovative organ preservation technique. Developing an understanding for the donor organ immune cell composition and its dynamic changes during NMP is essential.
T. Hautz, S. Salcher, M. Fodor, G. Sturm, S. Ebner, A. Mair, M. Trebo, G. Untergasser, S. Sopper, B. Cardini, A. Martowicz, J. Hofmann, S. Daum, M. Kalb, T. Resch, F. Krendl, A. Weissenbacher, G. Otarashvili, P. Obrist, B. Zelger, D. Öfner, Z. Trajanoski, J. Troppmair, R. Oberhuber, A. Pircher, D. Wolf, S. Schneeberger   +26 more
semanticscholar   +1 more source

Introducing Machine Perfusion into Routine Clinical Practice for Liver Transplantation in the United States: The Moment Has Finally Come

Journal of Clinical Medicine, 2023
While adoption of machine perfusion technologies into clinical practice in the United States has been much slower than in Europe, recent changes in the transplant landscape as well as device availability following FDA approval have paved the way for ...
K. Croome
semanticscholar   +1 more source

Portable hypothermic oxygenated machine perfusion for organ preservation in liver transplantation: A randomized, open-label, clinical trial

Hepatology, 2023
Background and Aims: In liver transplantation, cold preservation induces ischemia, resulting in significant reperfusion injury. Hypothermic oxygenated machine perfusion (HMP-O2) has shown benefits compared to static cold storage (SCS) by limiting ...
G. Panayotova, K. Lunsford, R. Quillin, Abbas Rana, V. Agopian, Grace S. Lee-Riddle, Daniela Markovic, F. Paterno, A. Griesemer, Arpit Amin, Diane Alonso, Juan P Rocca, Daniel Borja-Cacho, R. Hernandez-Alejandro, John J Fung, Shawn J. Pelletier, Shimul A. Shah, J. Guarrera   +17 more
semanticscholar   +1 more source

Impact of Portable Normothermic Blood-Based Machine Perfusion on Outcomes of Liver Transplant

JAMA Surgery, 2022
Key Points Question Can oxygenated portable normothermic perfusion of deceased donor livers for transplant improve outcomes compared with the current standard of care using ischemic cold storage?
J. Markmann, M. Abouljoud, R. Ghobrial, C. Bhati, S. Pelletier, A. Lu, S. Ottmann, T. Klair, C. Eymard, G. Roll, J. Magliocca, T. Pruett, Jorge D. Reyes, S. Black, C. Marsh, G. Schnickel, M. Kinkhabwala, S. Florman, S. Merani, A. Demetris, Shoko Kimura, M. Rizzari, A. Saharia, M. Levy, A. Agarwal, F. Cigarroa, J. Eason, Shareef M. Syed, W. Washburn, J. Parekh, Jang I. Moon, Alexander Maskin, H. Yeh, P. Vagefi, M. MacConmara   +34 more
semanticscholar   +1 more source

Donor Heart Preservation: Current Knowledge and the New Era of Machine Perfusion

International Journal of Molecular Sciences, 2023
Heart transplantation remains the conventional treatment in end-stage heart failure, with static cold storage (SCS) being the standard technique used for donor preservation.
Dimitris Kounatidis, Vassiliki Brozou, Dimitris Anagnostopoulos, C. Pantos, Athanasios Lourbopoulos, I. Mourouzis   +5 more
semanticscholar   +1 more source

Effects of machine perfusion strategies on different donor types in liver transplantation: a systematic review and meta-analysis

International Journal of Surgery, 2023
Background: The increasing use of extended criteria donors (ECD) sets higher requirements for graft preservation. Machine perfusion (MP) improves orthotopic liver transplantation (OLT) outcomes, but its effects on different donor types remains unclear ...
Aijun Liang, Weiye Cheng, P. Cao, Shaoru Cai, Linya Zhang, K. Zhong, Yu Nie   +6 more
semanticscholar   +1 more source

Current Evidence and Future Perspectives to Implement Continuous and End-Ischemic Use of Normothermic and Oxygenated Hypothermic Machine Perfusion in Clinical Practice

Journal of Clinical Medicine, 2023
The use of high-risk renal grafts for transplantation requires the optimization of pretransplant assessment and preservation reconditioning strategies to decrease the organ discard rate and to improve short- and long-term clinical outcomes.
Maxime Foguenne, S. MacMillan, P. Kron, J. Nath, A. Devresse, M. De Meyer, Mourad Michel, S. Hosgood, T. Darius   +8 more
semanticscholar   +1 more source